1. VITO NV | Boeretang 200 | 2400 MOL | Belgium | Tel. + 32 14 33 55 11 | www.vito.be
VITO supports healthcare
innovations and performs toxicity
screening
An Van Rompay, Hilda Witters, Rita Cortvrindt, Lieve Geerts
and Reinhilde Weltens
VITO NV, Boeretang 200, 2400 Mol, Belgium
ENVIRONMENT
HEALTH & SAFETY
Toxicology services and hands-on support
REACH & CLP
Have no secrets to us
Toxicology testing services
We perform
Medical devices
We take care of biocompatibility
Label
We apply
Validation Studies
We are your partner
Safety by design
We support the future
How can we help?
Our multi-disciplinary teams have the expertise to
accomplish all your toxicology and regulatory needs.
Data collection, compound analysis, fill the gaps
(QSAR’s or read across), perform testing services
(ecotoxicity, biodegradation studies, in vitro human
toxicity), validation studies, exposure scenarios,
safety analysis, second opinion,… full dossier
preparation and follow up.
GLP certified testing facility
EU-NETVAL registered lab
Skin irritation
» SkinEthicTM RHE, EpidermTM* (OECD 439)
Eye irritation
» BCOP (OECD 437), BCOP – LLBO
» SkinEthicTM HCE
» ICE (OECD 438)*, HET-CAM*
» EpiOcularTM EIT* (draft OECD)
» STE* (draft OECD)
Skin corrosion
» Corrositex® (OECD 435)
» SkinEthicTM RHE, Epiderm* (OECD 431)
Skin sensitization
» VITOSENS®
» DPRA* (OECD 442C)
» KeratinoSens* (OECD 442D)
Phototoxicity
» 3T3 NRU* (OECD 432), EpiDerm™*
Cytotoxicity (ISO 10993)
» Cell lines (HepG2, 3T3, …)
» Endpoints: NR-uptake, MTT,…
Inflammation responses
» Quantification of cytokines
Genotoxicity
» Ames II / MPF / Penta I
Embryo - & Developmental neurotoxicity
» Zebrafish embryo & larvae (up to age of 5 days)
Validation studies
Genomics
» qPCR
» Microarrays
Nano SafetyO
Endocrine disruptionO
In vitro toxicity &
biocompatibility tests
* Under implementation
O On request
Ecotoxicity &
biodegradation tests
Computational models &
expert analysis
Read across and QSAR
» Physicochemistry: SPARC, EPI-Suite
» OECD (Q)SAR Toolbox
» Environment: VEGA, BIOWIN, ECOSAR,
CASE Ultra, TOPKAT
» Human endpoints: ToxTree, VEGA, TTC
Exposure modelling
» Consumers: ConsExpo, AISE REACT, EN-forc
» Environment: EUSES
» Workers: ECETOC-TRA, Stoffenmanager, ART,
EMKG-EXPO, Riskofderm
» S-Risk, EN-forc and other expert models
Risk assessment
Socio-economic analysis
Product classification
» DETNET expert
Algae growth inhibition test
» Pseudokirchneriella subcapitata, OECD 201
Lemna growth inhibition test
» Lemna major, OECD 221
Daphnia immobility test
» Daphnia magna, OECD 202
Daphnia reproduction test
» Daphnia magna, OECD 211
Fish acute toxicity, and prolonged toxicity test
» Danio rerio & Oncorhynchus mykiss, OECD 203
– OECD 204
Fish embryo acute toxicity test (FET)
» Danio rerio, OECD 236
Fish, short-term toxicity test on Embryo and
Sac-fry stages
» Danio rerio, OECD 212
Worm mortality test
» Eisenia fetida, OECD 207
Worm reproduction test
» Eisenia fetida, OECD 222
Plant growth inhibition test
» Several species, OECD 208
Biodegradation tests
» OECD 301B, OECD 301D, OECD 302
Contact
An Van Rompay
Tel. +32 14 33 52 46
an.vanrompay@vito.be
Rita Cortvrindt
Tel. +32 477 277 006
rita.cortvrindt@vito,be