Many enterprises use Active Directory for authentication, server and workstation management, group policy management, and more. It’s also one of the first applications to be deployed on AWS by those building or migrating Windows applications at scale. There are two primary models for running Active Directory on AWS: AWS Managed Microsoft AD and self-managed Active Directory on Amazon EC2. We discuss best practices for securing Active Directory deployment on AWS and the shared responsibility model for running AWS Managed Microsoft AD. We also examine a reference architecture that follows these best practices. Services include AWS Managed Microsoft AD, Amazon EC2, Amazon EBS, Amazon VPC, and AWS KMS.