Tumor innervation2.pptx

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kerman university of medical science

Tumor innervation Journal club ali karimi sisakht

Health & Medicine

Tunneling Nanotubes: The Fuel of Tumor
Progression?
Pinto, Giulia, Christel Brou, and Chiara Zurzolo. "Tunneling Nanotubes: The Fuel of Tumor Progression?." Trends in Cancer (2020).

What happens to tumors in the absence of nerves?
Magnon, Claire, et al. "Autonomic nerve development contributes to prostate cancer progression." Science 341.6142 (2013).

Innervation Studies across Different Cancer Types
Reavis, Hunter D., H. Isaac Chen, and Ronny Drapkin. "Tumor Innervation: Cancer Has Some Nerve." Trends in Cancer (2020).

Potential Sources of Tumor Innervation
Reavis, Hunter D., H. Isaac Chen, and Ronny Drapkin. "Tumor Innervation: Cancer Has Some Nerve." Trends in Cancer (2020).

Electrical and synaptic integration of glioma into
neural circuits
Venkatesh, Humsa S., et al. "Electrical and synaptic integration of glioma into neural circuits." Nature 573.7775 (2019): 539-545.

Neuron-to-glioma synapses
Venkatesh, Humsa S., et al. "Electrical and synaptic integration of glioma into neural circuits." Nature 573.7775 (2019): 539-545.

Glioma membrane depolarization promotes glioma
progression
Venkatesh, Humsa S., et al. "Electrical and synaptic integration of glioma into neural circuits." Nature 573.7775 (2019): 539-545.

Increased neuronal excitability in glioma-infiltrated
brain.
Venkatesh, Humsa S., et al. "Electrical and synaptic integration of glioma into neural circuits." Nature 573.7775 (2019): 539-545.

Brain tumours manipulate neighbouring synapses
Allen, Nicola J. "Brain tumours manipulate neighbouring synapses." (2020).

Concept for a vicious cycle between neuronal
hyperexcitability,
Venkataramani, Varun, et al. "Synaptic input to brain tumors: clinical implications." Neuro-oncology (2020).

Pharmacologic Targets at the Neuron–Glioma
Interface
Wirsching, Hans-Georg, and Michael Weller. "Does Neuronal Activity Promote Glioma Progression?." Trends in Cancer 6.1 (2020): 1-3.

Potential therapeutic avenues
Venkataramani, Varun, et al. "Synaptic input to brain tumors: clinical implications." Neuro-oncology (2020).

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NRNB Annual Report 2011

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Human Genome Project is a worldwide scientific achievement. It was a thirteen-year project initiated in 1990 and completed in 2003. Human Genome Project helped a lot in the identification of diseased genes as DNA is very significant for understanding the diseased gene and their functions. It helped in the identification of disease loci for many diseases and presented their treatment through preventive measures. It identified the gene loci for many diseases like cancer, asthma, high blood pressure, diabetes type 2, obesity, Alzheimer's disease, Down's syndrome, Turner's syndrome, depression and many types of heart diseases including cardiovascular disease and coronary artery disease. This project does not directly treat the diseases but it helps in the identification of disease gene loci and then allows the treatment of disease through its preventive measures before the appearance of symptoms or at the initial stages of the disease through many techniques like gene therapy, pharmacogenomics, and targeted drug therapy. These are the helpful techniques in the diagnoses of the human disease gene locus.

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PAGE Running head: SCHIZOPHRENIA 1 Schizophrenia Vernessa Combs PSY350: Physiological Psychology December 10, 2019 Schizophrenia The topic selected was schizophrenia. This is a severe and chronic mental disorder affecting the way humans think, feel and behave. Although this mental disorder is not very common, it has disabling symptoms. Schizophrenia has continuously been viewed as a disorder that occurs in neurodevelopment. It is associated with a microdeletion syndrome of a chromosome. Neurons migrate to the pial surface from the brain's ventricular zone. "Migration of the neuron cell body is mediated via microtubule-based transport organized by the centrosome. First, the centrosome moves up the microtubule, followed by the nucleus and the cell body” (Pearlson, 2015). Neuronal migrations are reportedly caused by Reelin. The etiology of schizophrenia is unknown, however, several risk factors have been associated with its development. These include environmental and genetic factors. Genetic factors are, however, insufficient to account for the development of the disease. They must be accompanied by other factors for the disease to develop. "Because the concordance rate for monozygotic twins only approaches 50%, genetic makeup alone is not sufficient for the development of schizophrenia, and non-genetic or sporadic forms of the disorder must exist” (Miyamoto et al, 2013). Environmental factors that play an important role in the etiology of schizophrenia include obstetric complications such as hypoxia, preeclampsia, and premature birth. Other environmental factors include maternal viral infections and stress occurring in neurodevelopment. Stress during neurodevelopment may be caused by other factors such as microbial infections. The pathology of schizophrenia includes the transcriptional dysregulation at the cerebral cortex and chromosomal conformations. “Anatomic, neurotransmitter and immune system abnormalities have been implicated in the pathophysiology of schizophrenia” (Miyamoto et al, 2013). Differences have been observed in the brains of people with schizophrenia compared to the brains of people without the disease in neuroimaging studies. The medial temporal areas of the brain have a decreased volume while the ventricles are larger. Structural abnormalities such as volume reductions and ventricular enlargements have been associated with the disease. The dopaminergic system abnormalities are also associated with schizophrenia. The immune system is also disturbed in people with the disease. “Overactivation of the immune system (eg, from prenatal infection or postnatal stress) may result in overexpression of inflammatory cytokines and subsequent alteration of brain structure and function” (Nuckols et al, 2013). Anatomic abnormalities may also be observed in the hippocampus. In the prefrontal cortex, there has been a reported increase in neuronal density. One of the areas of the prefrontal cortex, area 9, has been found to h ...

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Title: Application of Checklist-Based Nursing Care Process in Patients Undergoing Intervention for Coronary Chronic Total Occlusion: A Quasi-Randomized Study Presenter: Sonia Pal, M.Sc. Nursing 2nd Year Journal: BMC Nursing (2023) Authors: Xia Ge, Haiyang Wu, Zhe Zang, and Jiayi Xie DOI: 10.1186/s12872-023-03627-8 Study Overview: This presentation focuses on the effectiveness of a checklist-based nursing care process for patients undergoing interventions for coronary chronic total occlusion (CTO). The study employs a quasi-randomized design to assess improvements in patient care outcomes. Key Points: Background: CTO interventions are complex, and traditional nursing methods have not been highly effective, necessitating the exploration of new approaches. Objective: To investigate the effectiveness of a checklist-based nursing care process in improving care quality, reducing patient anxiety, increasing patient satisfaction, and minimizing adverse events. Methodology: Design: Quasi-randomized study Setting: Department of Cardiology, Shengjing Hospital, China Medical University, Shenyang, China Participants: 120 patients undergoing CTO interventions Groups: Intervention group (checklist-based care) and control group (standard care) Tools: Preoperative and postoperative PCI nursing care checklists, Zung Self-Rating Anxiety Scale, satisfaction questionnaires for doctors and patients Ethical Considerations: The study adhered to the Declaration of Helsinki, with informed consent obtained from all participants. Results: The study aimed to demonstrate that checklist-based nursing care could enhance nursing efficiency and patient outcomes compared to conventional methods. Quality Control: A quality control team ensured adherence to the checklist and study protocol, with regular training and supervision of nursing staff. Conclusion: The presentation concludes with findings supporting the effectiveness of checklist-based nursing care in CTO interventions, suggesting improvements in patient care processes and outcomes. The study highlights the importance of structured nursing protocols in complex medical procedures.

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These lecture slides, by Dr Sidra Arshad, offer a simplified look into the mechanisms involved in the regulation of cardiac pumping: Learning objectives: 1. Discuss the significance of regulation of cardiac pumping 2. Discuss the concepts of preload and afterload 3. Discuss the mechanism and significance of Frank Starling’s Law 4. Discuss the intrinsic mechanisms of regulation of cardiac pumping 5. Discuss the effects of sympathetic and parasympathetic stimulation on the heart 6. Describe how serum potassium and calcium affect the heart function 7. Discuss the effect of body temperature on the heart function Study Resources: 1. Chapter 9, Guyton and Hall Textbook of Medical Physiology, 14th edition 2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition 3. Chapter 30, Ganong’s Review of Medical Physiology, 26th edition 4. Cardiac Cycle - StatPearls, https://www.ncbi.nlm.nih.gov/books/NBK459327/ 5. Chapter 14, Human Physiology An Integrated Approach, Dee Silverthorn, 8th ed

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Tumor innervation2.pptx

2. Tunneling Nanotubes: The Fuel of Tumor Progression? Pinto, Giulia, Christel Brou, and Chiara Zurzolo. "Tunneling Nanotubes: The Fuel of Tumor Progression?." Trends in Cancer (2020).

3. What happens to tumors in the absence of nerves? Magnon, Claire, et al. "Autonomic nerve development contributes to prostate cancer progression." Science 341.6142 (2013).

4. Innervation Studies across Different Cancer Types Reavis, Hunter D., H. Isaac Chen, and Ronny Drapkin. "Tumor Innervation: Cancer Has Some Nerve." Trends in Cancer (2020).

5. Potential Sources of Tumor Innervation Reavis, Hunter D., H. Isaac Chen, and Ronny Drapkin. "Tumor Innervation: Cancer Has Some Nerve." Trends in Cancer (2020).

6. Electrical and synaptic integration of glioma into neural circuits Venkatesh, Humsa S., et al. "Electrical and synaptic integration of glioma into neural circuits." Nature 573.7775 (2019): 539-545.

7. Neuron-to-glioma synapses Venkatesh, Humsa S., et al. "Electrical and synaptic integration of glioma into neural circuits." Nature 573.7775 (2019): 539-545.

8. Glioma membrane depolarization promotes glioma progression Venkatesh, Humsa S., et al. "Electrical and synaptic integration of glioma into neural circuits." Nature 573.7775 (2019): 539-545.

9. Increased neuronal excitability in glioma-infiltrated brain. Venkatesh, Humsa S., et al. "Electrical and synaptic integration of glioma into neural circuits." Nature 573.7775 (2019): 539-545.

10. Brain tumours manipulate neighbouring synapses Allen, Nicola J. "Brain tumours manipulate neighbouring synapses." (2020).

11. Concept for a vicious cycle between neuronal hyperexcitability, Venkataramani, Varun, et al. "Synaptic input to brain tumors: clinical implications." Neuro-oncology (2020).

12. Pharmacologic Targets at the Neuron–Glioma Interface Wirsching, Hans-Georg, and Michael Weller. "Does Neuronal Activity Promote Glioma Progression?." Trends in Cancer 6.1 (2020): 1-3.

13. Potential therapeutic avenues Venkataramani, Varun, et al. "Synaptic input to brain tumors: clinical implications." Neuro-oncology (2020).

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