features diagnosis treatment

1. Agnima Anne Varghese
119i5a
DERMATOLOGY

2. 
 Due to Neisseria gonorrhea.
 Gram negative, fastidious, catalase and oxidase positive,
glucose ferment and is diplococci
 Humans are the only natural host.
 Selective medium is THAYER MARTIN/ VPN agar.
 Non selective is Chocolate/ Blood Agar.
Introduction

4. 
 It enters mucosal cell with help of Pili and OPA protein and
goes inside neutrophils
 Cytokine and complement system brings about reactions.
 TNFα is the main one and IgG is the main immunoglobulin
seen.
 IgG fixes the compliment whereas LOS (lipo
oligosaccharides), seen in the bacteria, mediates and alters the
complements.
 This produces Multi drug resistance strains.
Pathology and Virulence

8. 
 Sexual contact
 Transplacental
 Also through saliva
Transmission

9. 
 It effects Skene gland, Bartholin gland, uerethra , cervix and
fallopian tubes.
 Mostly affected in females but is asymptomtic.
 Thick profuse green / yellow discharge.
 Red edematous external meatus and Inguinal lymph nodes
tender.
 Dysuria and general symptoms like fever, malaise etc.
 Urine test revels little mucopus usually turbid white are
present.
In girls

10. • Skenitis
Paraurethral ducts [Columnar epithelium] will have beads of pus and
abscess and drains to urinary meatus.
• Bartholinits
Causes difficulty in sitting and walking and tender low third labia
majora.
• Pelvic Inflammatory Diseases
• Fits Hugh Curtis Syndrome
PID with salpingitis
In Children,
Vulvo-Vaginitis
Before puberty, it is immature stratified squamous with poor
glycogen and alkaline pH. This is suitable for gonococcus.

11. Accidental contamination through towels is a possibility.
 Discharge
 Soreness
 Itchy
 Dysuria
Red edematous vulva with purulent pus.
Ophthalmianeonatarum
Chlamydia can also cause.
Develops within 7 days of birth and is bilateral ALWAYS.

13. 
 PCR and swab test is done
 NAAA [Nucleic Acid Amplification Assay]
Treatment include:
1. Ceftriaxone
2. Doxycycline
3. Azythromycin
4. Fluoroquinoles
Chlamydia mostly accompanies as urethritis hence 3 and 4.
Diagnosis & Treatment
Topical T/t of AgNO3 or
tetracycline for
opthalmianeonatarum

14. Thank You