Flavones comprise one of the largest groups of flavonoids, which are characterized by the presence of a double bond between carbon-2 and carbon-3, and the attachment of the B ring to carbon-2. Various types of flavones have been reported in wood or bark of higher plants, including simple flavones, C-methyl flavones, 5,7,2',4'-tetrahydroxy derivatives, and 5,7,2',4',5'-pentahydroxy derivatives. Flavones play important roles in plant signaling, defense and human health due to their antioxidant, anti-inflammatory and other pharmacological activities.

1. 1. flavones,
2. flavanones,
3. isoflavones,
• According to the oxidation status and saturation of the heterocyclic
ring, flavonoids are divided into several groups, which include
flavones
B
4. flavonols,
5. 3-deoxy flavonoids
6. anthocyaninsanthocyanins
Flavones comprise one of the largest groups, which are characterized by the
presence of a double bond between CC--22 andand CC--33, and the attachment of the B ring
to CC--22
A
Jan-SBBU

2. Ref. Nan Jiang, Plants 2016, 5(2), 27
Jan-SBBU

3. Occurrence of flavones
The various flavones that have been
reported in wood or bark of higher plants
are listed in Table
Type Structure (name) Genus, species
(family)
Location
(b=Bark, W=Wood, HW-Heart wood)
Simple flavones
• 5,6-dimethoxy Rutaceae B ‫وغيره‬ ‫مالٹا‬• 5,6-dimethoxy Rutaceae B ‫وغيره‬ ‫مالٹا‬
• 5,6,2'-trimethoxy -- B
• 5,7,3' ,4' -tetrahydroxy
(luteolin)
Rosaceae HW
C-Methyl flavones
• 5,7 -dihydroxy-6-C-methyl
• (strobochrysin)
Pinus (Pinaceae) HW
• 5-hydroxy-7 ,4' -dimethoxy-
6,8-di-Cmethyl
(eucalyptin)
Eucalyptus
(Myrtaceae)
HW
J. B. Harborne Jan-SBBU

4. Type Structure (name) Genus, species
(family)
Location
(b=Bark, W=Wood, HW-Heart wood)
5,7,2' ,4' -tetrahydroxy derivatives
• artocarpesin
• cycloartocarpesin
• oxydihydroartocarpesin
Artocarpus spp.
(Moraceae)
HW
• oxydihydroartocarpesin
• norartocarpin
• cycloartocarpin
• chaplashin
• integrin
• mulberrin
‫پهل‬ ‫روٹ‬
5,7,2',4' ,5' -pentahydroxy derivatives
• cycloheterophyllin
• isocycloheterophyllin
• heterophyllin
Artocarpus spp.
(Moraceaea)
B
J. B. Harborne Jan-SBBU

5. Type Structure (name) Genus, species
(family)
Location
(family) (b=Bark, W=Wood, HW-Heart wood)
Flavone O-glycosides
chrysin 5-glucoside
chrysin 7 -glucoside
Rosaceae B
W
Flavone C-glycosides
apigenin 8-glucoside (vitexin)
apigenin 6-glucoside (isovitexin)
agipenin 6,8-diglycosides
V. ucens
(Verbenaceae)
HW
J. B. Harborne Jan-SBBU

6. Bioflavonoids and their sources (from "Anti-inflammatory activity of natural dietary flavonoids" Min-Hsiung Pan, Food Funct., 2010, 1, 15-31Jan-SBBU

7. Bioflavonoids and their sources (from "Anti-inflammatory activity of natural dietary flavonoids“
Min-Hsiung Pan, Food Funct., 2010, 1, 15-31. https://pubs.rsc.org/en/content/articlehtml/2010/fo/c0fo00103a
Jan-SBBU

8. 1. Flavones are emerging as very important specialized metabolites involved in
plant signaling and defense, as well as key ingredients of the human diet, with
significant health benefits.
2. Flavones have antioxidant, anti-proliferative, anti-tumor, anti-microbial, acetyl
cholinesterase, anti-inflammatory activities and are also used in cancer,
cardiovascular disease, neurodegenerative disorders, etc*.
*Manjinder Singh, et al. European Journal of Medicinal Chemistry, 84, 2014, 206-239
Jan-SBBU