Omeprazole, sold under the brand names Prilosec and Losec, among others, is a medication used in the treatment of gastroesophageal reflux disease (GERD), peptic ulcer disease, and Zollinger–Ellison syndrome.It is also used to prevent upper gastrointestinal bleeding in people who are at high risk. Omeprazole is a proton-pump inhibitor (PPI) and its effectiveness is similar to other PPIs. It can be taken by mouth or by injection into a vein. Common side effects include nausea, vomiting, headaches, abdominal pain, and increased intestinal gas.[1][9] Serious side effects may include Clostridium difficile colitis, an increased risk of pneumonia, an increased risk of bone fractures, and the potential of masking stomach cancer.[1] It is unclear if it is safe for use in pregnancy.[1] It works by blocking the release of stomach acid.[1]

1. Omeprazole
Prepared by: Abdulaziz M.shahbaz

2. omeprazole
• Generic name: omeprazole
• Brand names: PriLOSEC
• Dosage forms:
– Packet: 2.5mg , 10mg
– Suspension: 2mg/ml
– Tablet/capsule: 10mg, 20mg, 40mg
– Oral disintegrating tablets: 20mg
• Drug class: Proton pump inhibitors
• Rout of administration:
• Orally
• capsule
• Powder for oral suspension
• Intravenously , infusion

3. Mechanism of action
Omeprazole inhibits secretion of gastric acid
by irreversibly blocking the enzyme system of
hydrogen/potassium adenosine
triphosphatase, the “proton pump” of the
gastric parietal cell.
resulting in suppression of gastric acid
secretion

4. uses
1. Peptic ulcer
2. GERD
3. H pylori infection
4. NSAID induced ulcer
5. Reflux esophagitis
6. Zollinger-Ellison syndrome
7. Prophylaxis for ulcers

5. Uses
• GERD:
–<1 year: Safety and efficacy not established
–5-10 kg: 5 mg PO qDay
–10-20 kg: 10 mg PO qDay
–>20 kg: 20 mg PO qDay

6. Uses
• Erosive Esophagitis
• <1 month: Safety and efficacy not established
• Aged 1 month to <1 year
• 3 to <5 kg: 2.5 mg qDay
• 5 to <10 kg: 5 mg qDay
• ≥10 kg: 10 mg qDay
• May treat for up to 6 weeks
• Aged 1-16 years
• 5 to <10 kg: 5 mg PO qDay
• 10 to <20 kg: 10 mg PO qDay
• ≥20 kg: 20 mg PO qDay
• May treat for 4-8 weeks

7. Adverse Effects
• Headache (7%)
• Abdominal pain (5%)
• Diarrhea (4%)
• Nausea (4%)
• Vomiting (3%)
• Flatulence (3%)
• Dizziness (2%)
• Upper respiratory infection (2%)
• Acid regurgitation (2%)
• Constipation (2%)
• Rash (2%)
• Cough (1%)