B lymphocytes provide a(n) humoral response to a pathogen. Mammalian B cells are produced and become mature in bonemarrow. B cell responses to antigen usually occur in the lymphnodes or spleen. B cells circulate between the blood, lymphoid tissues, and lymph fluid. A small percentage of circulating B cells directly recognize antigens and undergo cell division to create antibody-secreting plasma cells. B cells are derived from bone marrow in humans and bursa of fabricious in birds. They play a important role in humoral immunity. B cells circulate in the spllen and lymphnodes waiting for potential antigens. When they encounter an antigen, the B cells transform into plasma cells and produce antibodies against the antigen. Solution B lymphocytes provide a(n) humoral response to a pathogen. Mammalian B cells are produced and become mature in bonemarrow. B cell responses to antigen usually occur in the lymphnodes or spleen. B cells circulate between the blood, lymphoid tissues, and lymph fluid. A small percentage of circulating B cells directly recognize antigens and undergo cell division to create antibody-secreting plasma cells. B cells are derived from bone marrow in humans and bursa of fabricious in birds. They play a important role in humoral immunity. B cells circulate in the spllen and lymphnodes waiting for potential antigens. When they encounter an antigen, the B cells transform into plasma cells and produce antibodies against the antigen..