This presentation discusses colon specific drug delivery systems using modified chitosan as a carrier. It aims to minimize drug release in the upper gastrointestinal tract and target drug delivery specifically to the colon. The objectives are to develop an effective colon specific drug delivery system using modified chitosan, characterize the modified chitosan, prepare dosage forms using modified chitosan, and evaluate the formulations for colon specific delivery. The plan of work involves modification of chitosan by cross-linking, preparation and evaluation of dosage forms, and stability testing of the modified chitosan.
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1. A
PRESENTATION ON
COLON SPECIFIC DRUG DELIVERY SYSTEMS-MODIFIED
CHITOSAN AS CARRIER
By
Mr. VAIBHAV GAUTAM KATARE
M.Pharm. III rd SEM
(Department of Pharmaceutics)
RESEARCH GUIDE
Mr. R.S. SHENDGE
M. Pharm.
(Department of Pharmaceutics)
Year: 2013
Sanjivani College of Pharmaceutical Research And Education
, Kopargaon.
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2. Introduction
Colon Targeted Drug Delivery
Inflammatory Bowel Diseases (IBD)
Crohn's Disease And Ulcerative Colitis
High Level Of Inflammation
Various approaches
• The pH sensitive systems
• Timed release systems
• Microbial triggered systems
• Polysaccharide based systems
• Osmotically controlled drug delivery systems
• Pressure dependent release systems
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3. Review of literature
Review of literature:
Literature review for understanding the study was done by referring to
various National and International Journals, Databases, such as
International Pharmaceutical Abstracts, and various other web resources.
Bashardoust N et.al.,(2011);Preparation and In vitro Investigation of
Chitosan Compressed Tablets for Colon Targeting. The aim of the present
study was minimizing the drug release in upper gastro intestinal tract and
targeting to colon by using the principles of compression coat
Kumar S et.al.,(2011); Formulation and evaluation of Ketorolac
tromethamine tablets for time and pH dependent colon specific delivery.
.
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4. Review of literature
Chithaluru K. et.al.,(2011); Formulation and Evaluation of
Microbially triggered compression coated tablets of Ketorolac
Tromethiamine, Present study was designed to minimize the drug
release in upper gastro intestinal tract and target to colon by using the
principles of compression coat. Optimized F9 formulation was a
promising system targeting to colon for treatment of various colonic
diseases like Inflammatory Bowel disease (IBD).
Patel M. P. et.al.,(2010); Chitosan Mediated Targeted Drug Delivery
System: A Review-Chitosan has prompted the continuous movement
for the development of safe and effective drug delivery systems
because of its unique physicochemical and biological characteristics. In
vitro drug-release experiments carried out under conditions similar to
colon exhibited controlled release behaviour of the drug.
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5. Review of literature
Sonia T.A. et.al.,(2011); Chitosan and Its Derivatives for Drug
Delivery Perspective Chitosan is a
biodegradable, biocompatible, positively charged nontoxic
mucoadhesive biopolymer. These unique features of chitosan
have stimulated development of delivery systems for a wide
range of biological agents.
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6. Aim and Objectives
Aim of Research work:-To develop effective colon specific drug
delivery system by using modified chitosan.
Objectives: –
-Development of colon specific drug delivery.
-Characterization of Modified Chitosan.
-Modification of chitosan by cross linking with cross linkers.
-Evaluation of Modified chitosan.
-Preparation of Dosage Form by using Modified Chitosan.
-Evaluation of formed Formulations for colon Specific.
-Stability of Modified Chitosan.
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7. Need for the Study
Colon is having crohn’s disease & ulcerative colitis
causing huge inflammation to treat this inflammation by
targeting drug delivery to colon.
colon inflammation is difficult to treat by conventional
approach because of premature drug release in stomach
& small intestine to prevent this drug release and to
localized drug delivery to colon.
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8. Plan of Work
Review of Literature
Selection and Procurement of Drug
Characterization of Drug and Excipients
• Organoleptic Properties
• Solubility,
• UV Spectroscopy
• Construction of Beer’s And Lamberts plot
• FTIR analysis
• DSC analysis
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9. Plan of Work
Modification of chitosan by cross linking.
Evaluation of Modified chitosan.
Preparation of Dosage Form by using Modified Chitosan.
Evaluation & Development of formed Formulations for colon
Specific Drug Delivery.
Stability of Modified Chitosan.
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10. Methods of Proposed Research Work
Characterization done for checking of purity
UV Spectroscopy- To determine λ max & Beer’s and Lamberts limit.
FTIR Spectroscopy- For identification of drug & polymers and to
determine interaction between them.
DSC analysis – For measurement of heat required to increase the temperature.
Formulation Development – Rotary tablet compression machine.
Evaluation of Developed formulation- Dissolution study -In-vitro Drug
release study.
Results And Discussion
Summary And Conclusion
References
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11. References
Vemula S.K., Reddy P. and Reddy V.; Formulation and
evaluation of Ketorolac tromethamine tablets for time and pH
dependent colon specific delivery; JCPR 2011; 8 (1): 31-39
Bashardoust N.,Jenita J. L., and Zakeri-Milani P.; Preparation and
In vitro Investigation of Chitosan Compressed Tablets for Colon
Targeting;Advanced Pharmaceutical Bulletin; 2011 1(2), 87-92
Patel M.P.,Patel R. R.,Patel J.K.; Chitosan Mediated Targeted
Drug Delivery System: A Review;J Pharm Pharmaceut Sci; 2010
(3) 536 – 57
Sharma C.P.,Sonia T.A.; Chitosan and Its Derivatives for Drug
Delivery Perspective;Adv Polym Sci (2011) 243: 23–54
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12. References
Chithaluru K.and Tadikonda R.R.; Formulation and Evaluation of
Microbially triggered compression coated tablets of Ketorolac
Tromethiamine; Der Pharmacia Lettre, 2011: 3 (4) 29-39
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