Vaibhav katare 12345

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Vaibhav katare 12345

  1. 1. A PRESENTATION ON COLON SPECIFIC DRUG DELIVERY SYSTEMS-MODIFIED CHITOSAN AS CARRIER By Mr. VAIBHAV GAUTAM KATARE M.Pharm. III rd SEM (Department of Pharmaceutics) RESEARCH GUIDE Mr. R.S. SHENDGE M. Pharm. (Department of Pharmaceutics) Year: 2013 Sanjivani College of Pharmaceutical Research And Education , Kopargaon. 1
  2. 2. Introduction  Colon Targeted Drug Delivery  Inflammatory Bowel Diseases (IBD)  Crohn's Disease And Ulcerative Colitis  High Level Of Inflammation  Various approaches • The pH sensitive systems • Timed release systems • Microbial triggered systems • Polysaccharide based systems • Osmotically controlled drug delivery systems • Pressure dependent release systems 2
  3. 3. Review of literature  Review of literature: Literature review for understanding the study was done by referring to various National and International Journals, Databases, such as International Pharmaceutical Abstracts, and various other web resources. Bashardoust N et.al.,(2011);Preparation and In vitro Investigation of Chitosan Compressed Tablets for Colon Targeting. The aim of the present study was minimizing the drug release in upper gastro intestinal tract and targeting to colon by using the principles of compression coat Kumar S et.al.,(2011); Formulation and evaluation of Ketorolac tromethamine tablets for time and pH dependent colon specific delivery. . 3
  4. 4. Review of literature  Chithaluru K. et.al.,(2011); Formulation and Evaluation of Microbially triggered compression coated tablets of Ketorolac Tromethiamine, Present study was designed to minimize the drug release in upper gastro intestinal tract and target to colon by using the principles of compression coat. Optimized F9 formulation was a promising system targeting to colon for treatment of various colonic diseases like Inflammatory Bowel disease (IBD).  Patel M. P. et.al.,(2010); Chitosan Mediated Targeted Drug Delivery System: A Review-Chitosan has prompted the continuous movement for the development of safe and effective drug delivery systems because of its unique physicochemical and biological characteristics. In vitro drug-release experiments carried out under conditions similar to colon exhibited controlled release behaviour of the drug. 4
  5. 5. Review of literature  Sonia T.A. et.al.,(2011); Chitosan and Its Derivatives for Drug Delivery Perspective Chitosan is a biodegradable, biocompatible, positively charged nontoxic mucoadhesive biopolymer. These unique features of chitosan have stimulated development of delivery systems for a wide range of biological agents. 5
  6. 6. Aim and Objectives  Aim of Research work:-To develop effective colon specific drug delivery system by using modified chitosan.  Objectives: – -Development of colon specific drug delivery. -Characterization of Modified Chitosan. -Modification of chitosan by cross linking with cross linkers. -Evaluation of Modified chitosan. -Preparation of Dosage Form by using Modified Chitosan. -Evaluation of formed Formulations for colon Specific. -Stability of Modified Chitosan. 6
  7. 7. Need for the Study Colon is having crohn’s disease & ulcerative colitis causing huge inflammation to treat this inflammation by targeting drug delivery to colon.  colon inflammation is difficult to treat by conventional approach because of premature drug release in stomach & small intestine to prevent this drug release and to localized drug delivery to colon. 7
  8. 8. Plan of Work  Review of Literature  Selection and Procurement of Drug  Characterization of Drug and Excipients • Organoleptic Properties • Solubility, • UV Spectroscopy • Construction of Beer’s And Lamberts plot • FTIR analysis • DSC analysis 8
  9. 9. Plan of Work  Modification of chitosan by cross linking.  Evaluation of Modified chitosan.  Preparation of Dosage Form by using Modified Chitosan.  Evaluation & Development of formed Formulations for colon Specific Drug Delivery.  Stability of Modified Chitosan. 9
  10. 10. Methods of Proposed Research Work  Characterization done for checking of purity  UV Spectroscopy- To determine λ max & Beer’s and Lamberts limit. FTIR Spectroscopy- For identification of drug & polymers and to determine interaction between them.  DSC analysis – For measurement of heat required to increase the temperature.  Formulation Development – Rotary tablet compression machine.  Evaluation of Developed formulation- Dissolution study -In-vitro Drug release study.  Results And Discussion  Summary And Conclusion  References 10
  11. 11. References  Vemula S.K., Reddy P. and Reddy V.; Formulation and evaluation of Ketorolac tromethamine tablets for time and pH dependent colon specific delivery; JCPR 2011; 8 (1): 31-39  Bashardoust N.,Jenita J. L., and Zakeri-Milani P.; Preparation and In vitro Investigation of Chitosan Compressed Tablets for Colon Targeting;Advanced Pharmaceutical Bulletin; 2011 1(2), 87-92  Patel M.P.,Patel R. R.,Patel J.K.; Chitosan Mediated Targeted Drug Delivery System: A Review;J Pharm Pharmaceut Sci; 2010 (3) 536 – 57  Sharma C.P.,Sonia T.A.; Chitosan and Its Derivatives for Drug Delivery Perspective;Adv Polym Sci (2011) 243: 23–54 11
  12. 12. References  Chithaluru K.and Tadikonda R.R.; Formulation and Evaluation of Microbially triggered compression coated tablets of Ketorolac Tromethiamine; Der Pharmacia Lettre, 2011: 3 (4) 29-39 12
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