Letrozole Tablets for Treatment of Breast Cancer in Post-Menopausal Women

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Letrozole Tablets (Letromina) is used for the treatment of treatment of postmenopausal women (women who no longer have periods) with hormone receptor positive invasive breast cancer. It is also used for several off label uses such as ovarian stimulation by fertility doctors.

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Letrozole Tablets for Treatment of Breast Cancer in Post-Menopausal Women

  1. 1. Letrozole Tablets Letrozole Tablets (Letromina) is used for the treatment of local or metastatic breast cancer that is hormone receptor positive or has an unknown receptor status in postmenopausal women. It is also used for several off label uses such as ovarian stimulation by fertility doctors. © The Swiss Pharmacy, Geneva Switzerland
  2. 2. Letrozole Tablets Chemical Structure © The Swiss Pharmacy, Geneva Switzerland
  3. 3. Letrozole Tablets Uses of Letrozole Tablets Letrozole Tablets (Letromina) is used to treat breast cancer in post-menopausal women that is, women who no longer have periods, either naturally due to their age or after surgery or chemotherapy. Letrozole tablets are used for adjuvant treatment of postmenopausal women with hormone receptor positive invasive early breast cancer. It is also used to treat invasive early breast cancer in post menopausal women who have received prior treatment with a medication called Tamoxifen for five years. © The Swiss Pharmacy, Geneva Switzerland
  4. 4. Letrozole Tablets Uses of Letrozole Tablets Letrozole is also used as a first-line treatment in postmenopausal women with advanced breast cancer and advanced breast cancer after relapse or disease progression, in women with natural or artificially induced postmenopausal endocrine status, who have previously been treated with anti-oestrogens. Letrozole works by decreasing the amount of estrogen produced by the body. Reduction of estrogen can slow or stop the growth of some types of breast cancer cells that require estrogen to grow. Off label uses include ovarian stimulation by fertility doctors because it has fewer side-effects than clomiphene, treatment for gynecomastia, and treatment of endometriosis. © The Swiss Pharmacy, Geneva Switzerland
  5. 5. Letrozole Tablets Active Ingredient The active pharmaceutical ingredient contained in Letromina tablets is Letrozole. Each 2.5 mg tablet contains 2.5 mg of the active ingredient Letrozole. © The Swiss Pharmacy, Geneva Switzerland
  6. 6. Letrozole Tablets Recommended Adult Dosage The recommended dose of Letrozole Tablets (Letromina) is one 2.5 mg tablet administered once a day, with or without meals. The recommended adult dosage of is given below: ➔Use in Adjuvant Treatment and Extended Adjuvant Treatment of Early Breast Cancer: In the adjuvant and extended adjuvant setting, the treatment with Letrozole should continue for 5 years or until disease relapse/recurrence occurs, whichever comes first. ➔Use in First and Second-Line Treatment of Advanced Breast Cancer: In patients with advanced disease, treatment with Letrozole should continue until tumor progression is evident. © The Swiss Pharmacy, Geneva Switzerland
  7. 7. Letrozole Tablets Contraindications Letrozole tablets (Letromina 2.5mg) are contraindicated in patients with the following conditions: ➔Known hypersensitivity to Letrozole or any inactive ingredient of this medication. ➔Use of Letrozole is contraindicated in women of premenopausal endocrine status, including pregnant women. © The Swiss Pharmacy, Geneva Switzerland
  8. 8. Letrozole Tablets Side Effects of Letrozole Tablets The most common possible side effects of Letrozole tablets (Letromina 2.5 mg) occuring in 20% or more of the patients undergoing treatment were hot flashes, arthralgia (joint pain), flushing, asthenia, edema, arthralgia, headache, dizziness, hypercholesterolemia, increased sweating, bone pain and musculoskeletal problems. © The Swiss Pharmacy, Geneva Switzerland
  9. 9. Letrozole Tablets Warnings And Precautions ➔Use of Letrozole Tablets (Letromina) may cause decreases in bone mineral density (BMD). Bone mineral density monitoring is advised. ➔Caution is advised when driving or using machinery as fatigue, dizziness, and somnolence have been reported with the use of Letrozole tablets. ➔Subjects with cirrhosis and severe hepatic impairment who were dosed with 2.5 mg of Letrozole tablets experienced approximately twice the exposure to Letrozole as healthy volunteers with normal liver function. © The Swiss Pharmacy, Geneva Switzerland
  10. 10. Letrozole Tablets Warnings And Precautions ➔The potential risk/benefit to patients with creatinine clearance less than 10 mL/min should be carefully considered before administration of Letrozole tablets. ➔In patients whose menopausal status is unclear, luteinising hormone (LH), follicle-stimulating hormone (FSH) and/or oestradiol levels should be measured before initiating treatment with Letrozole tablets. ➔Co-administration of Letromina (Letrozole tablets) with Tamoxifen, other anti-oestrogens or oestrogen-containing therapies should be avoided as these substances may diminish the pharmacological action of Letrozole. © The Swiss Pharmacy, Geneva Switzerland
  11. 11. Letrozole Tablets Overdose Symptoms & Treatment As there have been very few isolated cases of Letrozole overdose that were reported, it is not clear what exactly to expect from an overdose of Letrozole tablets. In most cases, treatment for a overdose of Letrozole tablets will not be necessary. The single highest reported dose taken was 62.5 mg or 25 tablets. No serious side effects were reported. No specific treatment for Letrozole overdose is recommended, although emesis could be induced if the patient is alert. Supportive care with frequent monitoring of vital signs is recommended. © The Swiss Pharmacy, Geneva Switzerland
  12. 12. Letrozole Tablets Letromina 2.5 mg Tablets manufactured by Alpha-Pharma, India For more information click here © The Swiss Pharmacy, Geneva Switzerland

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