Fluorouracil Cream (Flonida Cream) is used by adults to treat skin conditions such as superficial pre-malignant and malignant skin lesions, keratoses, Bowen’s disease and superficial basal-cell carcinoma.

1. Fluorouracil Cream
Fluorouracil Cream (Flonida) is used by adults to
treat skin conditions on the face and front part of
the scalp called solar keratosis or actinic
keratosis. Flonida Cream is also used to treat
Superficial pre-malignant and malignant skin
lesions, Bowens disease (type of skin cancer)
and Superficial Basal-Cell Carcinoma.
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2. Fluorouracil Cream
Chemical Structure
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3. Fluorouracil Cream
Active Ingredient
The active pharmaceutical ingredient
contained in Flonida cream is
Fluorouracil.
Flonida cream 1% contains 1.0% of the
active ingredient Fluorouracil whereas
Flonida cream 5% contains 5.0% of the
active ingredient Fluorouracil.
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4. Fluorouracil Cream
Uses of Fluorouracil Cream
Fluorouracil Cream (Flonida) is used
for the topical treatment of superficial
pre-malignant and malignant skin
lesions, keratoses including senile,
actinic and arsenical forms, keratoa
canthoma, Bowen’s disease, superficial
basal-cell carcinoma.
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5. Fluorouracil Cream
Recommended Adult Dosage
Generic Fluorouracil cream (Flonida cream)
should be applied twice daily in sufficient quantity
to cover the entire area with a thin film. Generic
Fluorouracil cream should not be applied near the
eyes, nostrils or mouth. Flonida cream should be
applied ten minutes after thoroughly washing,
rinsing, and drying the entire area. Generic
Fluorouracil cream may be applied using the
fingertips. Immediately after application, the hands
should be thoroughly washed.
A treatment period of 2 to 6 weeks is usually
required depending on the indication being treated.
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6. Fluorouracil Cream
Contraindications
Generic Fluorouracil cream (Flonida cream)
is contraindicated in patients with the
following conditions:
➔Known hypersensitivity to Fluorouracil or any
inactive ingredient of this medication.
➔Fluorouracil cream (Flonida cream) is
contraindicated in women who are or may become
pregnant. If Flonida cream is used during
pregnancy, or if the patient becomes pregnant
while taking this drug, the patient should be
apprised of the potential hazard to the fetus.
© The Swiss Pharmacy, Geneva Switzerland

7. Fluorouracil Cream
Contraindications
Generic Fluorouracil cream (Flonida cream) is
contraindicated in patients with the following
conditions:
➔Known hypersensitivity to Fluorouracil or any
inactive ingredient of this medication. Fluorouracil
cream should not be used in patients with
dihydropyrimidine dehydrogenase (DPD) enzyme
deficiency.
➔Fluorouracil cream is not recommended for use
on children.
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8. Fluorouracil Cream
Side Effects of Fluorouracil Cream
The most common possible side effects
of Fluorouracil cream (Flonida cream)
are pain, pruritus, burning, irritation,
inflammation, allergic contact dermatitis
and telangiectasia have been reported.
Occasionally, hyperpigmentation and
scarring have also been reported.
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9. Fluorouracil Cream
Warnings And Precautions
➔It is not known whether Fluorouracil is excreted in human
milk. Because many drugs are excreted in human milk
and because of the potential for serious adverse reactions
in nursing infants from Fluorouracil, a decision should be
made whether to discontinue nursing or to discontinue the
drug, taking into account the importance of this medication
to the mother.
➔The potential for a delayed hypersensitivity reaction to
Fluorouracil exists. Patch testing to prove hypersensitivity
may be inconclusive.
➔Applications to mucous membranes should be avoided
due to the possibility of local inflammation and ulceration.
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10. Fluorouracil Cream
Warnings And Precautions
➔Patients should discontinue therapy with Carac if symptoms of
DPD enzyme deficiency develop. Rarely, unexpected, systemic
toxicity (e.g. stomatitis, diarrhea, neutropenia, and
neurotoxicity) associated with parental administration of
Fluorouracil has been attributed to deficiency of
dihydropyrimidine dehydrogenase “DPD” activity.
➔Occlusion of the skin with resultant hydration has been shown
to increase percutaneous penetration of several topical
preparations. If an occlusive dressing is used there may be an
increase in the incidence of inflammatory reactions in the
adjacent normal skin.
➔Flonida cream therapy is not advisable in persons who work
outdoors for prolonged periods in the sun. Excessive exposure
to sunlight or other forms of UV irradiation during treatment may
produce a diffuse phototoxic response in the areas of
application.
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11. Fluorouracil Cream
Overdose Symptoms & Treatment
Ordinarily, topical overdosage of Fluorouracil
cream (Flonida) will not cause acute problems. If
Fluorouracil cream is accidentally ingested,
induce emesis and gastric lavage. If Fluorouracil
cream accidentally comes in contact is made with
the eyes, flush the eyes with copious amounts of
water or normal saline. Administer symptomatic
and supportive care as needed.
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12. Fluorouracil Cream
Flonida -1% and 5% cream
manufactured by Shalaks
Pharmaceuticals Pvt. Ltd., India
For more information click here
© The Swiss Pharmacy, Geneva Switzerland