Crestor Tablets to treat high cholesterol and related conditions

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Crestor Tablets (Rosuvastatin calcium) is a synthetic lipid-lowering agent used in combination with exercise, diet, and weight-loss to treat high cholesterol and related conditions. It is also indicated for risk reduction of MI, stroke, and arterial revascularization procedures in patients without clinically evident CHD, but with multiple risk factors

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Crestor Tablets to treat high cholesterol and related conditions

  1. 1. Crestor Tablets Crestor Tablets (Rosuvastatin calcium) is a synthetic lipid-lowering agent used in combination with exercise, diet, and weight-loss to treat high cholesterol and related conditions. It is also indicated for risk reduction of MI, stroke, and arterial revascularization procedures in patients without clinically evident CHD, but with multiple risk factors. © The Swiss Pharmacy, Geneva Switzerland
  2. 2. Crestor Tablets Active Ingredient The active pharmaceutical ingredient contained in Crestor Tablets is Rosuvastatin calcium. © The Swiss Pharmacy, Geneva Switzerland
  3. 3. Crestor Tablets Chemical Structure © The Swiss Pharmacy, Geneva Switzerland
  4. 4. Crestor Tablets Indications Crestor Tablets (Rosuvastatin calcium) are used as an addition to diet when the response to diet and exercise is inadequate. Prevention of Major Cardiovascular events: In adult patients without documented history of cardiovascular or cerebrovascular events, but with at least two conventional risk factors for cardiovascular disease, Crestor Tablets (Rosuvastatin calcium) are used to: Reduce the risk of nonfatal myocardial infarction Reduce the risk of nonfatal stroke Reduce the risk of coronary artery revascularisation © The Swiss Pharmacy, Geneva Switzerland
  5. 5. Crestor Tablets Indications Hypercholesterolaemia: Reduce elevated LDL-C, total cholesterol, triglycerides and to increase HDL cholesterol in patients with primary hypercholesterolaemia (heterozygous familial and non familial) and mixed dyslipidaemia. © The Swiss Pharmacy, Geneva Switzerland
  6. 6. Crestor Tablets Recommended Dosage Crestor Tablets may be given at any time of the day, with or without food. The dosage of Crestor for various indications is given below: Prevention Of Major Cardiovascular Events: A dose of 20 mg once daily has been found to reduce the risk of major cardiovascular events. Hypercholesterolaemia: The usual dose range is 10 - 40 mg orally once a day. The dosage of Crestor should be individualised according to the goal of therapy and patient response. The majority of patients are controlled at the start dose. © The Swiss Pharmacy, Geneva Switzerland
  7. 7. Crestor Tablets Recommended Dosage Primary hypercholesterolaemia, mixed dyslipidaemia and isolated hypertriglyceridaemia: The usual start dose is 10 mg once a day. For patients with severe hypercholesterolaemia, a start dose of 20 mg may be considered. Homozygous familial hypercholesterolaemia: For patients with homozygous familial hypercholesterolaemia a start dose of 20 mg once a day is recommended. © The Swiss Pharmacy, Geneva Switzerland
  8. 8. Crestor Tablets Contraindications Crestor Tablets are contraindicated in patients with the following conditions: ➔Hypersensitivity to Rosuvastatin calcium, or any inactive component of this medication. ➔In pregnant women, while breast-feeding and in women of child-bearing potential not using appropriate contraceptive measures. ➔In patients with active liver disease or persistent, unexplained elevations in transaminases. ➔In patients with pre-disposing factors for myopathy/rhabdomyolysis. © The Swiss Pharmacy, Geneva Switzerland
  9. 9. Crestor Tablets Side Effects of Crestor Tablets (Rosuvastatin calcium) The most frequent side effects include Headache, myalgia, asthenia, constipation, dizziness, nausea, abdominal pain. The uncommon side effects include Pruritus, rash and urticaria. Rare side effects include Myopathy (including myositis), hypersensitivity reactions (including angioedema), rhabdomyolysis, pancreatitis. © The Swiss Pharmacy, Geneva Switzerland
  10. 10. Crestor Tablets Warnings And Precautions ➔Liver: Liver function tests should be performed before initiation of treatment and periodically thereafter. ➔Skeletal Muscle: As with other HMG-CoA reductase inhibitors, effects on skeletal muscle eg. uncomplicated myalgia, myopathy and, rarely, rhabdomyolysis, have been reported in patients treated with rosuvastatin ➔Race: Pharmacokinetic studies show an increase in exposure in Asian subjects compared with Caucasians © The Swiss Pharmacy, Geneva Switzerland
  11. 11. Crestor Tablets Warnings And Precautions ➔Diabetes Mellitus: There is sufficient evidence to support an association between statin use and new onset type 2 diabetes mellitus; however the risk appears to be mainly in patients already at increased risk of developing type 2 diabetes. Risk factors for the development of type 2 diabetes include raised fasting blood glucose, history of hypertension, raised triglycerides and raised body mass index. ➔Interstitial Lung Disease: Exceptional cases of interstitial lung disease have been reported with some statins, especially with long term therapy. Presenting features can include dyspnoea, non-productive cough and deterioration in general health (fatigue, weight loss and fever). © The Swiss Pharmacy, Geneva Switzerland
  12. 12. Crestor Tablets Warnings And Precautions ➔Children And Adolescents 10 To 17 Years Of Age: The evaluation of linear growth (height), weight, BMI (body mass index), and secondary characteristics of sexual maturation by Tanner staging in paediatric patients taking Crestor is limited to a one year period ➔Effect On Ability To Drive And Use Machines:Pharmacology testing revealed no evidence of a sedative effect of crestor. From the safety profile, Crestor is not expected to adversely affect the ability to drive or use machines. ➔Pregnancy And Lactation: The safety of Crestor Tablets (Rosuvastatin calcium) during pregnancy and whilst breast feeding has not been established. Women of child-bearing potential should use appropriate contraceptive measures. © The Swiss Pharmacy, Geneva Switzerland
  13. 13. Crestor Tablets Overdose Treatment There is no specific treatment in the event of overdose of Crestor Tablets (Rosuvastatin calcium). In the event of overdose, the patient should be treated symptomatically and supportive measures instituted as required. Haemodialysis is unlikely to be of benefit. © The Swiss Pharmacy, Geneva Switzerland
  14. 14. Crestor Tablets Crestor Tablets manufactured by Astra Zeneca UK For more information click here © The Swiss Pharmacy, Geneva Switzerland

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