Eltroxin Tablets for Treatment of Hypothyroidism and Goiter

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Eltroxin Tablets (Levothyroxine Sodium) is used to treat hypothyroidism, a condition where the thyroid gland does not produce enough thyroid hormone. Levothyroxine is also used to help decrease the size of enlarged thyroid glands and reduce the symptoms of low thyroid hormone.

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Eltroxin Tablets for Treatment of Hypothyroidism and Goiter

  1. 1. Eltroxin Tablets Eltroxin contains Levothyroxine Sodium that is identical to the thyroid hormone produced in the human thyroid gland. It is used to treat hypothyroidism, a condition where the thyroid gland does not produce enough thyroid hormone. Levothyroxine is also used to help decrease the size of enlarged thyroid glands (also called a goiter). Eltroxin helps to reduce the symptoms of low thyroid hormone such as weight gain, sensitivity to cold, lack of energy, and dry skin. © The Swiss Pharmacy, Geneva Switzerland
  2. 2. Eltroxin Tablets Active Ingredient The active ingredient present in Eltroxin Tablets is Levothyroxine Sodium. Eltroxin 50 mcg contains 50 micrograms (0.05 mg) of Levothyroxine Sodium whereas Eltroxin 100 mcg contains 100 micrograms (0.1 mg) of Levothyroxine Sodium. The inactive ingredients present are as per the old formula of GlaxoSmithKline. © The Swiss Pharmacy, Geneva Switzerland
  3. 3. Eltroxin Tablets Chemical Structure © The Swiss Pharmacy, Geneva Switzerland
  4. 4. Eltroxin Tablets Inactive ingredients present in Eltroxin 25 mcg tablets: ➔Sodium Citrate ➔Lactose ➔Starch Maize ➔Acacia Powder ➔Magnesium Stearate ➔Purified Water © The Swiss Pharmacy, Geneva Switzerland
  5. 5. Eltroxin Tablets Inactive ingredients present in Eltroxin 50 mcg tablets: ➔Sodium Citrate ➔Lactose ➔Starch Maize ➔Acacia Powder ➔Magnesium Stearate ➔Purified Water © The Swiss Pharmacy, Geneva Switzerland
  6. 6. Eltroxin Tablets Inactive ingredients present in Eltroxin 100 mcg tablets: ➔Sodium Citrate ➔Lactose ➔Starch Maize ➔Gelatin ➔Methyl Hydroxybenzoate ➔Propyl Hydroxybenzoate ➔Magnesium Stearate ➔Purified Water © The Swiss Pharmacy, Geneva Switzerland
  7. 7. Eltroxin Tablets Recommended Adult Dosage Eltroxin is administered as a single daily dose, on an empty stomach preferably one-half to one hour before breakfast. Eltroxin tablets should be taken at least 4 hours apart from medicines that are known to interfere with its absorption. The Initial recommended dose is 50 to 100 micrograms daily and adjusted at four or six week intervals by 50 micrograms until attainment of adequate clinical response. © The Swiss Pharmacy, Geneva Switzerland
  8. 8. Eltroxin Tablets Administration ➔Should preferably be taken on an empty stomach ➔Should be swallowed whole ➔Should be taken with a full glass of water ➔Eltroxin tablets should not be split © The Swiss Pharmacy, Geneva Switzerland
  9. 9. Eltroxin Tablets Contraindications ➔Hypersensitivity to Levothyroxine Sodium or any inactive ingredient of the preparation. ➔Patients with untreated subclinical or overt thyrotoxicosis ➔Patients with acute myocardial infarction ➔Patients with uncorrected adrenal insufficiency © The Swiss Pharmacy, Geneva Switzerland
  10. 10. Eltroxin Tablets Possible Side Effects ➔Immune system disorders: Hypersensitivity reactions such as skin rash and pruritis ➔Metabolism and nutrition disorders: Increased appetite, abdominal cramps, nausea, vomiting and diarrhea ➔Nervous system disorders: Excitability, insomnia, restlessness, headache, tremors, seizure © The Swiss Pharmacy, Geneva Switzerland
  11. 11. Eltroxin Tablets Possible Side Effects ➔Cardiac disorders: Anginal pain, cardiac arrhythmias, palpitations, tachycardia, increased blood pressure, heart failure, myocardial infarction ➔Respiratory, thoracic and mediastinal disorders: Dysponea ➔Skin and subcutaneous tissue disorders: Sweating, flushing, hair loss © The Swiss Pharmacy, Geneva Switzerland
  12. 12. Eltroxin Tablets Possible Side Effects ➔Musculoskeletal, connective tissue and bone disorders : Cramps in the skeletal muscle, muscular weakness, decreased bone mineral density. ➔Reproductive system and breast disorders: Menstrual irregularity, impaired fertility ➔General disorders and administration site conditions: Fatigue, heat intolerance, fever, excessive loss of weight. © The Swiss Pharmacy, Geneva Switzerland
  13. 13. Eltroxin Tablets Warnings And Precautions ➔Appropriate thyroxine dosage is based upon clinical assessment and laboratory monitoring of thyroid function tests. During the initial titration period, careful dosage titration and monitoring is necessary to avoid the consequences of under- or over-treatment. ➔Treatment with thyroxine in patients with panhypopituitarism or other causes predisposing to adrenal insufficiency may cause reactions including dizziness, weakness, malaise, weight loss, hypotension and adrenal crisis. It is advisable to initiate corticosteroid therapy before giving levothyroxine sodium in these cases. © The Swiss Pharmacy, Geneva Switzerland
  14. 14. Eltroxin Tablets Warnings And Precautions ➔Special care is needed in the elderly and in patients with symptoms of myocardial insufficiency or ECG evidence of myocardial infarction or ischaemia and also those with diabetes mellitus or insipidus. ➔Levothyroxine raises blood sugar levels and this may upset the stability of patients receiving antidiabetic agents. ➔Levothyroxine is excreted in breast milk in low concentrations and this may be sufficient to interfere with neonatal screening for hypothroidism. © The Swiss Pharmacy, Geneva Switzerland
  15. 15. Eltroxin Tablets Warnings And Precautions ➔In women, long-term levothyroxine sodium therapy has been associated with increased bone resorption, thereby decreasing bone mineral density, especially in post-menopausal women on greater than replacement doses or in women who are receiving suppressive doses of levothyroxine sodium. © The Swiss Pharmacy, Geneva Switzerland
  16. 16. Eltroxin Tablets Overdose Symptoms In addition to exaggeration of side effects the following symptoms may be seen: agitation, confusion, irritability, hyperactivity, headache, sweating, mydriasis, tachycardia, arrhythmias, tachypnoea, pyrexia, increased bowel movements and convulsions. Cerebral embolism, shock, coma, and death have also been reported. Seizures have occurred in a child ingesting 18 mg of levothyroxine. Symptoms may not necessarily be evident or may not appear until several days after ingestion of Levothyroxine Sodium. © The Swiss Pharmacy, Geneva Switzerland
  17. 17. Eltroxin Tablets Overdose Treatment Levothyroxine Sodium should be reduced in dose or temporarily discontinued if signs or symptoms of overdosage occur. In case of an acute overdose, symptomatic and supportive therapy should be instituted immediately. If not contraindicated (e.g., by seizures, coma, or loss of the gag reflex), the stomach should be emptied by emesis or gastric lavage to decrease gastrointestinal absorption. Activated charcoal or cholestyramine may also be used to decrease absorption. © The Swiss Pharmacy, Geneva Switzerland
  18. 18. Eltroxin Tablets Overdose Treatment Central and peripheral increased sympathetic activity may be treated by administering Beta-receptor antagonists, e.g., propranolol, provided there are no medical contraindications to their use. Provide respiratory support as needed; control congestive heart failure and arrhythmia; control fever, hypoglycemia, and fluid loss as necessary. Large doses of antithyroid drugs (e.g., methimazole or propylthiouracil) followed in one to two hours by large doses of iodine may be given to inhibit synthesis and release of thyroid hormones. Glucocorticoids may be given to inhibit the conversion of T4 to T3. © The Swiss Pharmacy, Geneva Switzerland
  19. 19. Eltroxin Tablets Eltroxin Tablets 25 mcg, 50 mcg & 100 mcg from GlaxoSmithKline. For more information click here © The Swiss Pharmacy, Geneva Switzerland

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