Insulinoma slideshow

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Insulinoma slideshow

  1. 1. INSULINOMAKatie Chambers, Sharon Kurval, MarcosReis
  2. 2. INSULINOMA Insulinomas are the most common tumors arising from the pancreatic islets of Langerhans Although most insulinomas are in the pancreas, distinguishing the location of the tumors is difficult at diagnosis The highest incidence is in people between 40 and 60 years of age, and women are affected slightly more often than men.
  3. 3. SYMPTOMS Anxiety Weight Gain (patient can become excessively obese) Behavior Changes Clouded Vision Confusion Convulsions Dizziness Headache Hunger Loss of Consciousness Rapid Heart Rate Sweating Tremor
  4. 4. CAUSES Insulinoma is a tumor found in the pancreas that continues to produce insulin even when your blood sugar drops too low High blood insulin levels cause low blood sugar levels called Hypoglycemia Hypogycemia may be mild, leading to symptoms such as anxiety and hunger or it can be severe, leading to seizures, coma and even death
  5. 5. THE PANCREAS The pancreas is an organ in the abdomen that makes several enzymes and hormones, including insulin. Insulin reduces the level of sugar(glucose) in the blood by helping it move into cells When your blood sugar level drops too low, the pancreas stops making insulin until your blood sugar returns to normal Insulinomas are rare and usually occur in single, small tumors in
  6. 6. EXAMS AND TESTS Fasting Test: every fasting test is started in the morning by means of an oral administration of 100 g of glucose Consists of an onset of blood sampling as late as after a 48h-fasting period http://www.insulinoma.net/english%20homepage/images/EHT_Con_Ins_ WZ.gif
  7. 7. EXAMS AND TESTS After fasting, your blood may be tested for:  Blood C-peptide level  Blood glucose level  Blood insulin level  Drugs that cause the pancreas to release insulin CT or MRI scan of the abdomen may be done to look for a tumor in the pancreas. If the test is negative, one of the following tests may be performed:  Endoscopic ultrasound  Octreotide Scan  Pancreatic Arteriography  Pancreatic venous sampling for insulin
  8. 8. SCANShttp://hormones.gr/images/dyn/zogr- http://static.ddmcdn.com/gif/mri-10.jpgeus.jpg
  9. 9. TREATMENTS Surgery is the recommended treatment for insulinoma. The tumor is first found by tests or surgery. If there is a single tumor it will be removed.  Ifthere are many tumors, part of the pancreas will need to be removed (partial pancreatectomy).  At least 15% of the pancreas must be left to produce its enzymes.  This may prevent the surgeon from removing the whole insulinoma tumor.
  10. 10. TREATMENTS If no tumor is found during surgery, you may get the drug diazoxide to lower insulin production and avoid hypoglycemia. A diuretic is given to prevent the body from retaining fluid.  Octreotide is used to http://www.unboundedmedicine.com/images/insulinoma7 %5B1%5D.jpg reduce insulin release in some patients
  11. 11. HISTORY Historically, the three components of insulinoma  1) symptoms of hypoglycemia  2) documented plasma glucose of less than 50 mg/dL at the time of hypoglycemic symptoms  3) relief of these symptoms with administration of glucose has been referred to as Whipples triad.
  12. 12. WORKS CITED The New York Times. (2010). Insulinoma. Retrieved February 21, 2012, from http://health.nytimes.com/health/guides/disease/insulinoma/overview.html Medline Plus. (2012). Insulinoma. Retrieved February 21, 2012, from http://www.nlm.nih.gov/medlineplus/ency/article/000387.htm Center for Pancreatic and Bilary Disorders. (2002). Insulinoma. Retrieved February 21, 2012, from http://www.surgery.usc.edu/divisions/tumor/pancreasdiseases/web%20pages/Endocr ine%20tumors/pancreatic%20tumors/insulinoma.html UpToDate. (2012). Insulinoma. Retrieved February 21, 2012, from http://www.uptodate.com/contents/insulinoma Insulinoma UK. (2011). What is an insulinoma?. Retrieved February 21, 2012, from http://www.insulinoma.co.uk/page_1218566549343.html eHow. (2011). How to Diagnose Insulinoma. Retrieved February 22, 2012, from http://www.ehow.com/how_2086786_diagnose-insulinoma.html Medscape Reference. (2012). Insulinoma Treatment & Management. Retrieved February 22, 2012, from http://emedicine.medscape.com/article/283039-overview University of Maryland Medical Center. (2010). Insulinoma – Treatment. Retrieved February 22, 2012, from http://www.umm.edu/ency/article/000387trt.htm

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