Grant Euroskin Presentation

Epidemiological evidence for a role of UV-induced vitamin D in cancer (and other disease) prevention William B. Grant, Ph.D. Sunlight, Nutrition, and Health Research Center (SUNARC) San Francisco, CA 94109, USA www.sunarc.org

Disclosure ,[object Object],[object Object],[object Object],[object Object]

Outline Health Effects of UV and Vitamin D ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Ecological Studies of UVB and Cancer Incidence and Mortality ,[object Object],[object Object],[object Object]

350 400 450 500 400 500 450 350 300 300 350 300 300 350

Cohort Studies of Vitamin D and Cancer Risk ,[object Object],[object Object],[object Object],[object Object]

Prospective Study of Vitamin D and Calcium and Cancer Risk ,[object Object],[object Object]

Studies Based on Indices of UVB Irradiance Rather than Dose ,[object Object],[object Object]

Meta-analysis of Risk of Second Cancer After Diagnosis of NMSC When adjusted for smoking (lung cancer risk ratio = 1.0), diagnosis of NMSC is significantly inversely correlated with colon cancer risk

Meta-analysis of Risk of Second Cancer After Diagnosis of NMSC ,[object Object],[object Object]

Cancer in Spain ,[object Object],[object Object]

Cancer in Spain Results ,[object Object],[object Object]

Tuohimaa P, et al. Does solar exposure, as indicated by the non-melanoma skin cancers, protect from solid cancers: Vitamin D as a possible explanation. Eur J Cancer. 2007 May 29;43:1701-1712. ,[object Object],[object Object],[object Object],[object Object],[object Object]

Tuohimaa P, et al. Does solar exposure, as indicated by the non-melanoma skin cancers, protect from solid cancers: Vitamin D as a possible explanation. Eur J Cancer. 2007 May 29;43:1701-1712. ,[object Object],[object Object],[object Object]

Number of Observational Studies on UVB and Cancer Risk Reduction ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Dose-Response Relations ,[object Object],[object Object],[object Object],[object Object]

Respiratory Viral Diseases ,[object Object],[object Object],[object Object]

Aloia JF, Li-Ng M. Links Correspondence. Epidemiol Infect. 2007 Mar 12;:1-4 [Epub ahead of print] Results of a prospective double blind vitamin D supplementation study involving 208 African-American post-menopausal women living in or near Mineola, New York. The numbers refer to cases of common cold or influenza.

Human Cathelicidin ,[object Object],[object Object]

Vitamin D and Innate Immune System ,[object Object]

Sepsis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Extension to Autoimmune Diseases ,[object Object],[object Object],[object Object],[object Object]

Multiple Sclerosis (MS) ,[object Object],[object Object],[object Object]

Hypothesis for MS ,[object Object],[object Object]

Metabolic Diseases ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Vitamin D supplementation and total mortality: a meta-analysis of randomized controlled trials. Autier P. Gandini S . Arch Intern Med. 2007 Sep 10;167(16):1730-7. ,[object Object],[object Object],[object Object],[object Object]

Estimated Health Benefit of 2000 IU of Vitamin D3 per day - Canada ,[object Object],[object Object],[object Object],[object Object]

Summary and Conclusion ,[object Object],[object Object],[object Object],[object Object]

Grant Euroskin Presentation

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Grant Euroskin Presentation