This document discusses using scientific evidence to shape public policy on violence prevention. It argues that brain science can challenge core beliefs that fuel tough-on-crime approaches and open the door for alternative strategies. Lasting change requires grassroots movements, leadership, and aligning interests. Evidence shows that early childhood education, parent support, and addressing disadvantage can work long-term, while developing adolescent skills and trauma-informed approaches can have shorter-term impacts. The Cure Violence model effectively reduces violence and spreads organically. Federal policies now emphasize evidence-based, two-generation strategies and performance partnerships to support reentry.