do you love your liver

1. H
OW much DO YOU L
OVE
YOUR L R?
IVE

2. Do you love your liver?
How Can You Love it If You Don't Know it?

3. Hi... I'm Your Liver!
• I am the largest organ in the body, integral to
most metabolic functions of body, performing
over 500 tasks
• Only 10-20% of my functions is required to
sustain life
• Removal of me will result in death within 24
hours

4. Let me tell you how much I love you…in 9
ways

5. 1. I store the iron reserves you need, as well as a lot of
vitamins and other minerals.
Without me, you wouldn't have the strength to carry on!

6. 2. I make bile to help digest your food.
Without me, you'd waste away to nothing.

7. 3. I detoxify poisonous chemicals you give me, and that
includes alcohol, beer, wine and drugs (prescribed and
over-the-counter) as well as illegal substances.
Without me, your "bad" habits would kill you.

8. 4. I store energy, like a battery, by stockpiling sugar
(carbohydrates, glucose and fat) until you need it.
Without me, the sugar level in your blood could fall
dramatically and you'd go into a coma.

9. You couldn't have gotten out of bed
this morning if I weren't on the job!.

10. 5. I make the blood that got your system going even
before you were born.
Without me, you wouldn't be here!

11. 6. I manufacture new proteins that your body needs to
stay healthy and grow.
Without me, you wouldn't grow properly!

12. 7. I remove poisons from the air, exhaust smoke and
chemicals you breathe.
Without me, you'd be poisoned by pollutants!

13. 8. I make clotting factors that stop the bleeding when you
accidentally prick yourself.
Without me, you'd bleed to death!

14. 9. I help defend you against the germs going into your
body all the time. I take those cold germs, flu bugs and
other germs you encounter, and knock them dead - or at
least weaken them.
Without me, you'd be a sitting duck for every infection
known to man.

15. That's how much I love you... but do
you love me?

16. Now,
let us share about a most common
liver disease – fatty liver …..

17. Fatty Liver
What is it?
• Fatty liver is the collection of excessive amounts
of fat inside liver cells, also called steatosis.
• Mostly triglycerides.

18. Common type of Fatty Liver
1. Nonalcoholic
fatty liver disease
(NAFLD) - affect
people who drink
little or no
alcohol.
•simple fatty liver
(steatosis),
usually causes
no liver damage.

19. 2. Nonalcoholic
steatohepatitis
(NASH), a more
serious type.
Cause by hepatitis
infection, malnutrition,
obesity, diabetes
mellitus, and Reye's
syndrome .
In some cases, this can
progress either to
cirrhosis, which can
produce progressive,
irreversible liver
scarring, or to liver
cancer.

20. NORMAL
“Resistant”
↑
FFA
Ins R
(↑ Insulin)
↑ TNF
↓ Adiponectin
↑ FFA oxidizing
enzymes
A
Hepatic Insulin
resistance
↑ CPT I
↑ FFA oxidation
STEATOSIS
(Ins Resistant)
“Vulnerable”
↑ TNFα/
d’nect
↑ PPAR-α
The first
hit
Endotoxin
↑ Adipose tissue
↓e- flow
Oxidative stress
NASH
The second hits

21. Reye's Syndrome - a deadly disease, attack any child or
adult without warning.
All body organs are affected, with the liver and brain
suffering most seriously.
Cause and cure remain unknown, research has established
a link between Reye's Syndrome and the use of aspirin and
other salicylate-containing medications.

23. Normal
(0-30%)
3. Alcoholic steatosis.
Caused by alcohol
abuse
Prevalence of
histological diagnoses in
unselected drinkers
Steatosis
(60-100%)
Steatohepatitis
(20-30%)
Fibrosis or
cirrhosis
(<10%)

24. Mechanisms of ALD
↑ Gut permeability
Alcohol Metabolism
CYP2E1/Fe
Endotoxin
Oxidative stress
Lipid peroxidation
KC
Cytokines
Necroinflammation
and/or apoptosis
ADH
Acetaldehyde
Immunological
damage (adducts)

25. What are the symptoms?
• Fatty liver usually produces no symptoms.
• Jaundice
• right-side abdominal pain
• abdominal swelling
• fever.

26. At more advanced stage, liver becomes cirrhosis
• Cirrhosis refers to scarring of the liver. It replaces healthy
tissue.
• Scar tissue cannot do what healthy liver tissue does.
• Scar tissue also blocks the normal flow of blood through the
liver.
• Cirrhosis can be life-threatening, but it can also be
controlled if treated early.

27. How is it diagnosed?
• The liver may be tender when the abdomen is pressed.
• Blood tests - for liver function.
• Ultrasound or abdominal CT scan.

28. What is the treatment?
• Treatment for fatty liver is aimed at eliminating or treating
the cause of the condition.
• In some cases, fatty liver is reversible if caught early in its
development.
• Pregnancy-related fatty liver is treated by delivering the
baby, if viable.
• Severe liver damage can occur if fatty liver is left untreated.
In these cases, the patient may eventually require a liver
transplant

29. That shows some people do not
love me enough… 

30. Now,
Let me tell you some easy ways to
love me, your liver

31. • Don't drown me in beer, alcohol or wine!
Even one drink is too much for some people
and could scar me for life.

32. • Watch those drugs!
All drugs are chemicals, and
when you mix them up without
a doctor's advice you could
create something poisonous
that could damage me badly.
• I scar easily.. and those scars, called "cirrhosis" are permanent.
Medicine is sometimes necessary. But taking pills when they
aren't necessary is a bad habit. All those chemicals can really hurt
a liver.

33. • Be careful with aerosol
sprays!
Remember, I have to
detoxify what you breathe
in, too. So when you are
cleaning with aerosol
cleaners, make sure the
room is ventilated, or wear
a mask.
• That goes double for bug sprays, mildew sprays, paint
sprays and all those other chemical sprays you use. Be
careful what you breathe!

34. • Watch what gets on your skin! Those insecticides you put on trees
and shrubs not only kill bugs they can get to me right through your
skin and destroy my cells, too. Remember they're all chemicals.
Cover your skin with gloves, long sleeves, a hat and mask every
time insecticides are in the air or if you're handling them.

35. • Don't eat too much fatty food!
I make the cholesterol your body needs, and I try to make the
right amount.
Give me a break. Eat a good, well balanced nourishing diet. If
you eat the right stuff for me, I'll really do my stuff for you!

36. WARNING:
I can't and won't tell you I'm in trouble until I'm almost at
the end of my rope... and yours.
Remember: I am a non-complainer. Overloading me with
drugs, alcohol and other junk can destroy me! This may be
the only warning you will ever get.

37. Take My Advice, Please!
• Check me out with your doctor.
• Blood screening tests can identify some
trouble.
• If I'm soft and smooth, that's good. If I'm
hard and bumpy, that could mean trouble.
• If your doctor suspects trouble, ULTRA
SOUND and CT scans can look into it.
• My life, and yours, depends on how you
treat me.

38. Now you know how much I care for you.
Please treat me with tender loving care.
Your silent partner and ever-loving
lover….LIVER

39. Thanks….
But it’s not the end !!!