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molecular genetics
- 2. 1953: James Watson and Francis Crick presents the DNA structure Basis: Maurice Wilkins and Rosalind Franklin’s X-ray crystallography images of DNA Watson, Crick and Wilkins – Nobel prize in Physiology or Medicine in 1962
- 3. Nucleic Acid Chemistry purine pyrimidine
- 6. Base-pairing
- 13. DNA REPLICATION 1. Origin of DNA Replication
- 15. 2. Unwinding of the DNA 3. Stabilization of the Y-junction 4. Polymerization of the nucleotides
- 16. 5. Formation of the Leading and Lagging Strand 6. Formation of the Replisome 7. Replication of the Leading and Lagging Strand
- 18. 8. Primer Removal and Gap Filling 9. Ligation
- 19. Ligation- the polymerase cannot attach together the fragments, the enzyme DNA ligase completes this task by making a phosphodiester bond
- 21. 1. Initiation of Transcription 2. Polymerization
- 23. 3. Termination
- 32. 1. INITIATION
- 33. 2. ELONGATION
Editor's Notes
- James Watson and Francis Crick publish a description of the double-helix structure of DNA. The paper acknowledges that the authors were "stimulated by knowledge of the unpublished experimental results of" Maurice Wilkins and Rosalind Franklin, whose x-ray crystallography images of DNA suggested the structure. Franklin died in 1958; Watson, Crick and Wilkins are awarded the Nobel Prize in Physiology or Medicine in 1962. 1962 Nobel Prize Watson, J. D. and F. H. C. Crick, 1953. Molecular structure of nucleic acids: a structure for desoxyribonucleic acid. Nature 171: 737-738. DNA Helix Turns 40, ASM News 60,1994. p