Well Intellecte- amazing product for your wellness
•Download as PPT, PDF•
10 likes•6,949 views
an amazing product for your complete wellness
Recommended
More Related Content
What's hot
What's hot (20)
Viewers also liked
Viewers also liked (14)
Similar to Well Intellecte- amazing product for your wellness
Similar to Well Intellecte- amazing product for your wellness (20)
Recently uploaded
Recently uploaded (20)
Well Intellecte- amazing product for your wellness
- 1. Modicare Well Intellecte Healthy Living & Anti-ageing Supplement Containing New Zealand Pine Bark Essence(Enzogenol), Acerola Cherry Extract and Citrus Bioflavonoids
- 2. Well Intellecte Enzogenol •Contains broad spectrum antioxidants that are known for fighting the effects of ageing and promoting good health. •Antioxidants are critical to good health as they scavenge and neutralise free radicals that can cause oxidative stress and damage cells and tissues. FAIRPLAY QUALITY CREATIVITY & INNOVATION TEAMWORK
- 3. Well Intellecte Acerola Cherry Extract •Natural source of Vitamin C, an essential nutrient that helps to maintain bones and teeth, supports tissue growth, repair, wound healing and collagen production, important for healthy skin, cartilage, tendons, ligaments, and blood vessels. •Additionally, vitamin C's antioxidant effects boost the immune system against infection and neutralize damaging free radicals. FAIRPLAY QUALITY CREATIVITY & INNOVATION TEAMWORK
- 4. Well Intellecte Citrus Bioflavonoids •Rich source of phytonutrients . • Provides flavonoids rutin & hesperidin. Powerful plant nutrients that help strengthening the circulatory system. FAIRPLAY QUALITY CREATIVITY & INNOVATION TEAMWORK
- 5. Well Intellecte Advantage Stay Young… Stay Active … Anti-ageing Antioxidant Brain Health Skin Health Eye Health FAIRPLAY QUALITY CREATIVITY & INNOVATION TEAMWORK
- 7. Stay Young…. MRP:Rs. 1300/DP: Rs.995/BV: 700 Pack Size: 30 Veg. Capsules Product Code: FS5020 FAIRPLAY QUALITY CREATIVITY & INNOVATION TEAMWORK
- 8. Well Intellecte Science Behind FAIRPLAY QUALITY CREATIVITY & INNOVATION TEAMWORK
- 9. What is Enzogenol Enzogenol is a 100% natural, highly effective mixture of natural antioxidant and anti-inflammatory plant compounds extracted from the bark of New Zealand grown Pinus Radiata trees. The particular plant compounds in Enzogenol, collectively known as polyphenols, include proyanidins (also called OPC), bioflavonoids and organic acids. Enzogenol contains over 80% OPC These polyphenols are a natural and health promoting part of our diet that we normally obtain through eating fruits and vegetables. Enzogenol is derived from pine bark with a special, internationally patented, pure water extraction method without the use of chemicals. FAIRPLAY QUALITY CREATIVITY & INNOVATION TEAMWORK
- 10. Flavonoid Content of Enzogenol 200 g Fresh Fruit & 500g Fresh Vegetables 100 mg Enzogenol® Based on the USDA database for flavonoid content in foods counting 29 & 54 different types of fruits & vegetables respectively FAIRPLAY QUALITY CREATIVITY & INNOVATION TEAMWORK
- 11. Enzogenol Video • New Zealand Advantage FAIRPLAY QUALITY CREATIVITY & INNOVATION TEAMWORK
- 12. New Zealand Advantage Video FAIRPLAY QUALITY CREATIVITY & INNOVATION TEAMWORK
- 13. Well Intellecte Health Benefits of Enzogenol FAIRPLAY QUALITY CREATIVITY & INNOVATION TEAMWORK
- 14. Enzogenol Anti-ageing •Enzogenols powerful complex of broad spectrum flavonoid antioxidants and phenolic acids are proven to slow down the ageing process. •The trial on two groups of mice, one having Enzogenol and the other having no Enzogenol showed an 18.4% increase in average life expectancy. Longevity video FAIRPLAY QUALITY CREATIVITY & INNOVATION TEAMWORK
- 15. Longevity Video FAIRPLAY QUALITY CREATIVITY & INNOVATION TEAMWORK
- 16. Enzogenol Anti-ageing Inference from the mice trial •Slows down the pre-mature ageing. •Improved over all health and appearance. •Increased mobility •Increased strength. •Increased activeness & alertness FAIRPLAY QUALITY CREATIVITY & INNOVATION TEAMWORK
- 17. Enzogenol Powerful Antioxidant •Contains broad spectrum antioxidants that are critical to good health as they scavenge and neutralise free radicals that can cause oxidative stress and damage cells and tissues. •Curbing the activity of free radicals in your body, helps to slow down the processes that cause disease and ageing, and can contribute to a longer, healthier life. •Studies show that Enzogenol can protect the building blocks: DNA & Proteins - Helps in reducing DNA damage in the blood leukocytes by over 40% - Helps in reducing protein oxidation levels in the body by up to 50% - Helps in reducing oxidative damage to the body. - Superior Antioxidant than Vitamin C, Catechin and Maritime Pine Bark Extract FAIRPLAY QUALITY CREATIVITY & INNOVATION TEAMWORK
- 19. Enzogenol Brain Health Exciting new research carried out at the Brain Science Institute at Swinburne University in Australia has shown Enzogenol may protect the brain from ageing and age related diseases whilst at the same time significantly improve cognitive performance. Help Brain Boost •Helps in recovery of functional brain age of between 7-12 years * •Improve Your Memory •Better concentration & focus •Improve Your IQ •Improve Alertness •Sharpen Your Mind •Better response time & faster thinking •Protection from Cognitive Decline FAIRPLAY QUALITY CREATIVITY & INNOVATION TEAMWORK
- 20. Enzogenol Brain Health Enzogenol – New Zealand GHQ Study 2010 •21 participants: 12 women, 9 men •47-80 years of age, mean 64.6 •Took Enzogenol for 5 weeks •General Health Questionnaire: •12 questions to assess brain and general health 14 of 21 = 67% improved (8F, 6M) 6 of 21 = 29% no change (3F, 3M) 1 of 21 = 4% deteriorated (F) FAIRPLAY QUALITY CREATIVITY & INNOVATION TEAMWORK
- 21. Enzogenol Attention deficit-hyperactivity disorder (ADHD) •Parents and Health Practitioners have discovered Enzogenol as an effective nutritional therapy to support children with symptoms of hyperactivity, attention deficits and behaviour problems. • Several paediatricians specialising in the treatment of children with ABC disorders have found the high strength Enzogenol formulation, to be a very useful adjunct treatment for children. There are case studies that supports that. •The ABC = Attention Behavior Continuum comprises a number of conditions that include Attention Deficit Disorder, with and without Hyperactivity, Asperger's Syndrome, Autism and other conditions that share similar behavioral phenotypes. FAIRPLAY QUALITY CREATIVITY & INNOVATION TEAMWORK
- 22. Enzogenol Attention deficit-hyperactivity disorder (ADHD) •Dr. Leila Masson from the Mother-Well Clinic in Auckland, New Zealand had this to say about her experience: “Enzogenol is a safe and effective alternative to medication for children with hyperactivity and problems concentrating. I have noticed improvements in my patients within a few weeks of starting this potent antioxidant. Parents and teachers consistently report that the children are calmer and more focused. I recommend a trial of Enzogenol for any child with features of ADHD or autism.” Enzogenol can help Improve Concentration & Attention in Children FAIRPLAY QUALITY CREATIVITY & INNOVATION TEAMWORK
- 23. Enzogenol Cognitive Performance Video FAIRPLAY QUALITY CREATIVITY & INNOVATION TEAMWORK
- 24. Enzogenol Skin Health (Enzogenol can help) •Binds and protects collagen •Stimulates skin cell growth •Boosts skin cells natural internal free radical defences •Protects skin cells from external free radical damage •Protects skin cells from damaging UV radiation i.e. sunburns etc. •Collagen, one of the body's most widespread proteins, is the primary component of the skin. • The interlacing collagen fibres give the skin it's strength, elasticity and smoothness. •Enzogenol binds to and stabilises collagen, and protects collagen degradation. FAIRPLAY QUALITY CREATIVITY & INNOVATION TEAMWORK
- 25. Skin Health Antioxidant Protection UV Protection => Enzogenol protects the skin from oxidation and UV damage FAIRPLAY QUALITY CREATIVITY & INNOVATION TEAMWORK
- 26. Enzogenol Eye Health • Enzogenol had benefits for people’s eye sight. • These benefits were effective in a population of older people that commonly experience difficulties with their eye sight. •Significant improvement in distant vision and the deterioration in acuity of vision was five times less with Enzogenol.+ Vitamin C as compared to intake of only Vitamin C. •Demonstrating that Enzogenol may help vision and may reduce the deterioration in eye sight that is a normal consequence of getting older. FAIRPLAY QUALITY CREATIVITY & INNOVATION TEAMWORK
- 28. Enzogenol Headache (Migrane) • Enzogenol study on migraine sufferers with a long term history of migraine and who had previously failed to respond to various pharmacological approaches, sufferers were given Enzogenol for 3 months*. •The data showed that Enzogenol was associated with beneficial effects on parameters of migraine attack frequency and severity. FAIRPLAY QUALITY CREATIVITY & INNOVATION TEAMWORK
- 29. Migraine Enzogenol – Migraine Study 20091 53% (18 of 34) of patients responded: • 79% reduction in headache days • 50% reduction in severity • 89% reduction in disability 1. Chayasirisobhon, 2009, World Congress of Neurology, Bangkock FAIRPLAY QUALITY CREATIVITY & INNOVATION TEAMWORK
- 30. Well Intellecte is not intended to diagnose, treat, cure or prevent any disease. The information given herein is not a medical advice for self-treatment and is only for informational purpose. Person with medical conditions, pregnant and lactating women should consult their Physician. Source of information available on Enzogenol is from the site www.enzogenol.com and other public domains and Modicare do not warranty/attest/endorse the accuracy of the same. The information given is for information purpose only. FAIRPLAY QUALITY CREATIVITY & INNOVATION TEAMWORK
- 31. Thank You FAIRPLAY QUALITY CREATIVITY & INNOVATION TEAMWORK
Editor's Notes
- Acerola Cherry Nutritional benefits:Vitamin C Potassium Magnesium Other Minerals The cherry can help with:Immune Function Dysentery Diarrhea Possibly the richest source of vitamin C among fruits, the cherry is extremely popular for its health benefits. The most important thing that sets cherry apart from any other fruit is its vitamin C content. Its extremely high vitamin C content, the cherry can help boost your immune system, strengthen your liver, improve your skin condition, and increases your body’s ability to repair tissues quickly. It also helps you prevent colds, infections, hair loss, and dental problems.The cherry contains anthocyanins – substances which are highly anti-inflammatory in nature. So, it is very good at relieving headaches. Eating an acerola cherry can have the same effect as taking ibuprofen or aspirin for your headache.The cherry is an excellent source of vitamin A, which is a known antioxidant. A regular intake of vitamin A tends to improve your vision and reduces the risk of cataracts and other such eye problems. Since it is a powerful antioxidant, it fights the free radicals which cause the maximum damage to your skin. As a result, you can stay away from skin problems.The fruit also contains high levels of potassium which can elevate your mood, regulate your heart function, and keep your blood pressure in control.It is also rich in vitamin B, calcium, magnesium, folate, and phosphorous. Folate in particular helps in the formation of new cells in your body, reduces the risk of heart diseases, and protects small children against mental problems and debilitating diseases.It is full of antioxidants like carotenoids and flavonoids, which, needless to say, are extremely important for your good health. It has been proven clearly that consuming antioxidant rich fruits regularly will help you stay away from health problems like heart diseases and cancer. http://lozzswellnessstore.weebly.com/1/post/2012/07/the-amazing-benefits-of-acerola-cherry.html
- Citrus Bioflavonoids Enhances the action of vitamin C. Includes rutin and hesperidin. Works as an antioxidant by scavenging free radicals. http://www.vitabase.com Citrus-bioflavonoids (hesperidin, rutin) Rutin is a natural bioflavonoid, which may help to maintain capillary strength and help to reduce the risk of easy bruising and swelling. Bioflavonoids may help maintain healthy cardiovascular function and can assist in maintaining capillary health. Rutin may reduce swelling and bruising after sports injuries. http://www.naturesown.com.au Health and Wellness Library: Hesperidin a look at the health benefits of Hesperidin and its role in human nutritionAlso Known as Hesperin Methyl-Chalcone, Citrus Bioflavonoid About Hesperidin Hesperidin is a flavonoid found in citrus fruits. It's found in the richest concentrations in the peel and pulp, or membranes, of the fruit. Its benefits include improved blood flow and integrity of blood vessels. Hesperidin is helpful in lowering blood pressure and cholesterol. It may improve fibroid tumors, endometriosis, and PMS ailments. It also facilitates a reduction in hay fever and allergy symptoms by inhibiting the release of histamines. Nutritional Role of Hesperidin Citrus bioflavonoids are used for the treatment of capillary fragility and venous insufficiency conditions like varicose veins, hemorrhoids, diabetic vascular disease, and diabetic retinopathy. Studies have found that people who suffer from varicose veins and hemorrhoids often have a deficiency of Hesperidin. Hesperidin is used in Europe for the treatment of chronic venous insufficiency and hemorrhoids. This flavonoid also works with Vitamin C to maintain collagen health. Hesperidin has positive benefits for the cardiovascular system, lowering blood pressure and cholesterol levels. Health Benefits of Hesperidin in Human Nutrition For antioxidant properties For anti-inflammatory properties For anti-cancer properties For vascular system and integrity of blood vessels For cardiovascular system - cholesterol and blood pressure For bone density loss For hay fever and allergies For hemorrhoids and varicose veins For mild sedative properties For eye health For skin For fibroids, endemetriosis, and PMS symptoms Usage Guidelines for Hesperidin Hesperidin is considered safe to use. Consult your health professional first, if you are pregnant, lactating, or taking blood thinner medications. Hesperidin Facts for Informational Purposes Only Readers should not use this information for self-diagnosis or self-treatment, but should always consult a medical professional regarding any medical problems and before undertaking any major dietary changes. This information is not meant to be substituted for medical advice. http://www.nutriherb.net/hesperidin_health_benefits.html
- Citrus Bioflavonoids Enhances the action of vitamin C. Includes rutin and hesperidin. Works as an antioxidant by scavenging free radicals. http://www.vitabase.com Citrus-bioflavonoids (hesperidin, rutin) Rutin is a natural bioflavonoid, which may help to maintain capillary strength and help to reduce the risk of easy bruising and swelling. Bioflavonoids may help maintain healthy cardiovascular function and can assist in maintaining capillary health. Rutin may reduce swelling and bruising after sports injuries. http://www.naturesown.com.au Health and Wellness Library: Hesperidin a look at the health benefits of Hesperidin and its role in human nutritionAlso Known as Hesperin Methyl-Chalcone, Citrus Bioflavonoid About Hesperidin Hesperidin is a flavonoid found in citrus fruits. It's found in the richest concentrations in the peel and pulp, or membranes, of the fruit. Its benefits include improved blood flow and integrity of blood vessels. Hesperidin is helpful in lowering blood pressure and cholesterol. It may improve fibroid tumors, endometriosis, and PMS ailments. It also facilitates a reduction in hay fever and allergy symptoms by inhibiting the release of histamines. Nutritional Role of Hesperidin Citrus bioflavonoids are used for the treatment of capillary fragility and venous insufficiency conditions like varicose veins, hemorrhoids, diabetic vascular disease, and diabetic retinopathy. Studies have found that people who suffer from varicose veins and hemorrhoids often have a deficiency of Hesperidin. Hesperidin is used in Europe for the treatment of chronic venous insufficiency and hemorrhoids. This flavonoid also works with Vitamin C to maintain collagen health. Hesperidin has positive benefits for the cardiovascular system, lowering blood pressure and cholesterol levels. Health Benefits of Hesperidin in Human Nutrition For antioxidant properties For anti-inflammatory properties For anti-cancer properties For vascular system and integrity of blood vessels For cardiovascular system - cholesterol and blood pressure For bone density loss For hay fever and allergies For hemorrhoids and varicose veins For mild sedative properties For eye health For skin For fibroids, endemetriosis, and PMS symptoms Usage Guidelines for Hesperidin Hesperidin is considered safe to use. Consult your health professional first, if you are pregnant, lactating, or taking blood thinner medications. Hesperidin Facts for Informational Purposes Only Readers should not use this information for self-diagnosis or self-treatment, but should always consult a medical professional regarding any medical problems and before undertaking any major dietary changes. This information is not meant to be substituted for medical advice. http://www.nutriherb.net/hesperidin_health_benefits.html
- In vitro assays*
- Citrus Bioflavonoids Enhances the action of vitamin C. Includes rutin and hesperidin. Works as an antioxidant by scavenging free radicals. http://www.vitabase.com Citrus-bioflavonoids (hesperidin, rutin) Rutin is a natural bioflavonoid, which may help to maintain capillary strength and help to reduce the risk of easy bruising and swelling. Bioflavonoids may help maintain healthy cardiovascular function and can assist in maintaining capillary health. Rutin may reduce swelling and bruising after sports injuries. http://www.naturesown.com.au Health and Wellness Library: Hesperidin a look at the health benefits of Hesperidin and its role in human nutritionAlso Known as Hesperin Methyl-Chalcone, Citrus Bioflavonoid About Hesperidin Hesperidin is a flavonoid found in citrus fruits. It's found in the richest concentrations in the peel and pulp, or membranes, of the fruit. Its benefits include improved blood flow and integrity of blood vessels. Hesperidin is helpful in lowering blood pressure and cholesterol. It may improve fibroid tumors, endometriosis, and PMS ailments. It also facilitates a reduction in hay fever and allergy symptoms by inhibiting the release of histamines. Nutritional Role of Hesperidin Citrus bioflavonoids are used for the treatment of capillary fragility and venous insufficiency conditions like varicose veins, hemorrhoids, diabetic vascular disease, and diabetic retinopathy. Studies have found that people who suffer from varicose veins and hemorrhoids often have a deficiency of Hesperidin. Hesperidin is used in Europe for the treatment of chronic venous insufficiency and hemorrhoids. This flavonoid also works with Vitamin C to maintain collagen health. Hesperidin has positive benefits for the cardiovascular system, lowering blood pressure and cholesterol levels. Health Benefits of Hesperidin in Human Nutrition For antioxidant properties For anti-inflammatory properties For anti-cancer properties For vascular system and integrity of blood vessels For cardiovascular system - cholesterol and blood pressure For bone density loss For hay fever and allergies For hemorrhoids and varicose veins For mild sedative properties For eye health For skin For fibroids, endemetriosis, and PMS symptoms Usage Guidelines for Hesperidin Hesperidin is considered safe to use. Consult your health professional first, if you are pregnant, lactating, or taking blood thinner medications. Hesperidin Facts for Informational Purposes Only Readers should not use this information for self-diagnosis or self-treatment, but should always consult a medical professional regarding any medical problems and before undertaking any major dietary changes. This information is not meant to be substituted for medical advice. http://www.nutriherb.net/hesperidin_health_benefits.html
- Citrus Bioflavonoids Enhances the action of vitamin C. Includes rutin and hesperidin. Works as an antioxidant by scavenging free radicals. http://www.vitabase.com Citrus-bioflavonoids (hesperidin, rutin) Rutin is a natural bioflavonoid, which may help to maintain capillary strength and help to reduce the risk of easy bruising and swelling. Bioflavonoids may help maintain healthy cardiovascular function and can assist in maintaining capillary health. Rutin may reduce swelling and bruising after sports injuries. http://www.naturesown.com.au Health and Wellness Library: Hesperidin a look at the health benefits of Hesperidin and its role in human nutritionAlso Known as Hesperin Methyl-Chalcone, Citrus Bioflavonoid About Hesperidin Hesperidin is a flavonoid found in citrus fruits. It's found in the richest concentrations in the peel and pulp, or membranes, of the fruit. Its benefits include improved blood flow and integrity of blood vessels. Hesperidin is helpful in lowering blood pressure and cholesterol. It may improve fibroid tumors, endometriosis, and PMS ailments. It also facilitates a reduction in hay fever and allergy symptoms by inhibiting the release of histamines. Nutritional Role of Hesperidin Citrus bioflavonoids are used for the treatment of capillary fragility and venous insufficiency conditions like varicose veins, hemorrhoids, diabetic vascular disease, and diabetic retinopathy. Studies have found that people who suffer from varicose veins and hemorrhoids often have a deficiency of Hesperidin. Hesperidin is used in Europe for the treatment of chronic venous insufficiency and hemorrhoids. This flavonoid also works with Vitamin C to maintain collagen health. Hesperidin has positive benefits for the cardiovascular system, lowering blood pressure and cholesterol levels. Health Benefits of Hesperidin in Human Nutrition For antioxidant properties For anti-inflammatory properties For anti-cancer properties For vascular system and integrity of blood vessels For cardiovascular system - cholesterol and blood pressure For bone density loss For hay fever and allergies For hemorrhoids and varicose veins For mild sedative properties For eye health For skin For fibroids, endemetriosis, and PMS symptoms Usage Guidelines for Hesperidin Hesperidin is considered safe to use. Consult your health professional first, if you are pregnant, lactating, or taking blood thinner medications. Hesperidin Facts for Informational Purposes Only Readers should not use this information for self-diagnosis or self-treatment, but should always consult a medical professional regarding any medical problems and before undertaking any major dietary changes. This information is not meant to be substituted for medical advice. http://www.nutriherb.net/hesperidin_health_benefits.html
- OPC: Oligomeric Proanthocyanidins
- USDA: US Department of Agriculture
- Enzogenols powerful complex of broad spectrum flavonoid antioxidants and phenolic acids are proven to slow down the ageing process – not just the visible signs of ageing, like fine lines and wrinkles, but the critical hidden oxidative stress damage that is linked to a host of age related degenerative diseases such as arthritis, cancer, heart disease, diabetes, cognitive function and strokes.
- Enzogenols powerful complex of broad spectrum flavonoid antioxidants and phenolic acids are proven to slow down the ageing process – not just the visible signs of ageing, like fine lines and wrinkles, but the critical hidden oxidative stress damage that is linked to a host of age related degenerative diseases such as arthritis, cancer, heart disease, diabetes, cognitive function and strokes.
- Enzogenols powerful complex of broad spectrum flavonoid antioxidants and phenolic acids are proven to slow down the ageing process – not just the visible signs of ageing, like fine lines and wrinkles, but the critical hidden oxidative stress damage that is linked to a host of age related degenerative diseases such as arthritis, cancer, heart disease, diabetes, cognitive function and strokes.
- Antioxidants & Health http://www.enzogenol.com/Default.aspx?page=1066 This section gives some general explanations on how antioxidants, free radicals, oxidative stress and flavonoids relate to our body's health and well-being.The Role of AntioxidantsScientists have discovered that Enzogenol's highly effective and complex blend of antioxidants help to fight the free radicals that cause damage to the cells in our bodies.Antioxidants are vital in combating the free radicals that are constantly forming in our bodies due to oxidation. Free radicals damage the cells in our bodies, and an imbalance of free radicals causes oxidative stress which can cause grave disturbances in cell metabolism. Curbing the activity of free radicals in your body, helps to slow down the processes that cause disease and ageing, and can contribute to a longer, healthier life.Our bodies gain antioxidants from two sources:Our body's in-house antioxidants, such as superoxide dismutase, catalase and glutathione. Dietary antioxidants, from sources such as fruits, vegetables, nuts and grains. As we grow older our body's defense system loses its effectiveness and we hold fewer antioxidants. Fewer free radicals are neutralised and this can lead to a slow build-up of damaged molecules in the body.Therefore, to reduce the damage to our bodies caused by free radicals, we are wise to add antioxidants to our diets.Enzogenol is a blend of special antioxidants including proanthocyanidins (also called OPC, oligomeric procyanidins), numerous other flavonoids, and organic acids. This complex blend makes Enzogenol one of the most powerful and effective antioxidants available to combat free radical damage.Many researchers claim that dietary changes designed to decrease the rate of free radical reactions in the body can increase the span of healthy life by years. Flavonoids like those in Enzogenol are antioxidant compounds found in plants. They are natural dietary disease-preventing, health-promoting substances.Back to topFree Radicals - the cause of oxidative stress and DNA damageJust as oxidation takes place all around us, it also occurs in our bodies. Millions of chemical reactions involving oxidation take place in our bodies every second.An imbalance of free radicals causes oxidative stress, and oxidative stress can cause damage to the building blocks of our body: DNA, proteins and lipids.Some fast facts about free radicals and oxidative stress:Free radicals are unstable, reactive molecules that often contain oxygen. They are unstable because they have one free reactive electron and they desperately want to pair this free electron with another electron to become stable. To get another electron they rob one from anything they can. Healthy cells in our bodies are a good source for these electrons.Free radicals go about their business in our bodies relentlessly and very quickly, and can cause a lot of damage.It is estimated that our DNA receives about 10,000 "hits" from free radicals per cell per day (Ames, 1993).An imbalance of free radicals in the body is called oxidative stress. Our cells can cope with some oxidative stress as they have developed endogenous antioxidants that are the defense mechanisms fighting off the constant attack from free radicals. Our body-cells have also developed repair mechanisms that are there to ensure that damaged molecules and cells do not cause permanent harm to our entire body. However not all damage can be repaired and the unrepaired damage can accumulates in the body.Major oxidative stress can cause grave disturbances in cell metabolism and contribute to human disease. Tissue damage and injury can also lead to oxidative stress. Oxidative stress can cause DNA damage, lipid peroxidation, protein damage and ischaemic (lack of oxygen) injury.The human body constantly produces free radicals and other oxygen derived molecules (such as hydrogen peroxide). It has a relatively small reserve of antioxidant defense capacity.Today, people continuously subject themselves to many substances and activities that increase the level of free radicals in their bodies, so the body can easily become overpopulated with oxygen-derived species that upset cell biochemistry. Sources of free radicals include metabolism by-products, macrophages and neutrophils, UV radiation, pollution, fatty foods, chemicals, cigarette smoke and exercise.Associated diseases and conditionsMany conditions have been linked to free radical damage and oxidative stress:Allergies Alzheimer's Amyotrophic Lateral Sclerosis (ALS) Cancer, including bladder, breast, cervical, colorectal, lung melanoma, ovarian/endometrial, prostate, stomach, upper aerodigestive tract Cardiovascular Disease Cataracts Cystic Fibrosis Diabetes Diabetic Neutrophy Glaucoma Huntington's Disease Macular Degeneration Multiple Sclerosis Muscular Dystrophy Pancreatitis Parkinson's Disease Rheumatoid Arthritis and other inflammatory conditions Schizophrenia Stroke Tardive DyskinesiaFlavonoids - a key ingredientFlavonoids are antioxidant compounds found in plants, and are natural disease-preventing, health-promoting dietary substances. Epidemiological studies have shown that higher intake of flavonoids is associated with lower disease frequency and better health. However, studies have also shown that our normal intake of flavonoids through eating a range of fruits and vegetables is not adequate with todays average diets.Flavonoids are some of the most powerful and effective antioxidant compounds available to humans - and since we are unable to produce flavonoids ourselves, we must get them from the food we eat and from supplements.Pine bark extracts are a particularly good source of highly concentrated flavonoid compounds. Enzogenol, with its potent pine bark extract and pure water extraction process, is one of the most effective ways in which we can stock up on the amounts of flavonoids we need to protect our health.Flavonoid-related facts - more than just an antioxidantFlavonoids are diverse both in their characteristics and chemical structures. More than 4000 flavonoids have been identified and some say there could be as many as 20,000 in plants.A well-balanced extract reflects the full spectrum of flavonoid compounds, including proanthocyanidins, across all molecular weights. In addition to the antioxidant activity, plant flavonoids have a wide range of other biological effects including anti-inflammatory, antibacterial, antiviral, collagen stabilising, and important effects on cell signalling. Flavonoids from many plant sources have been used throughout the world as medical treatments for many ailments and disorders.All plant extracts are made up of many compounds, with the range related to the biological evolution of the source material. All materials are not equal in this regard - over time, evolution has developed very complex compounds which provide sophisticated defense mechanisms for plants. Tree bark is nature's ultimate defense system, providing protection to trees for decades and even centuries.The study of flavonoidsResearch into flavonoids has dramatically increased over the past two decades.Flavonoids first came into the spotlight in the 1930s when Szent-Györgyi and his colleagues extracted two flavonoids from citrus fruit. They investigated the effects of the flavonoids and found they decreased the fragility and permeability of people's capillaries. This is why flavonoids were then called "vitamin P" - for permeability.This was probably the first study undertaken on the effect of flavonoids on human health, but the work could not be repeated so the claim that flavonoids were vitamins was dropped in the 1950s.Since then, many biological effects countering inflammatory, bacterial, viral, microbial, hormonal, carcinogenic, neoplastic and allergic disorders (Middleton, 1996) have been reported for flavonoids in in vitro and in vivo systems.Flavonoids exert these antioxidant effects by neutralising all types of oxidising radicals (Bors et al, 1998) including the superoxide (Robak, et al, 1998) and hydroxyl radicals (Husain, et al, 1987) and by chelation. A chelator binds to metal ions in our bodies to prevent them being available for oxidation.Back to topReferencesAmes, BN, Shigenaga, MK, Hagen, TM (1993) Oxidants, antioxidants, and the degenerative diseases of aging. Proc. Natl. Acad. Sci. USA: 90, 7915-7922Bors, W, Heller, W, Michel, C. (1998) The Chemistry of Flavonoids. From Flavonoids in Health and Disease, Edited by C A Rice-Evans and L Packer, Marcel Dekker, New York.Hertog, MGL, Feskens EJM, Hollman PCH, Katan MB, Kromhout, D (1993) Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study Lancet 342, 1007-1011Husain, S R, Cillard, J, Cillard, P (1987) Hydroxyl Radical Scavenging Activity of Flavonoids. Phytochemistry, 26 (9)Keli, SO, Hertog MGL, Feskens EJM, Kromhout D (1996) Dietary Flavonoids, Antioxidant Vitamins, and Incidence of Stroke. Arch Intern Med 156, 637-642Middleton, E (1996) Biological Properties of Plant Flavonoids: An Overview. International Journal of Pharmacognosy 34 (5)Pryor, WA, Cornicelli, JA< Devall, LJ, Tait, B, Trivedi, BK, Witak, DT, Wu, M (1993) J.Org.Chem. 58 (13), 3521-3531Robak, J, Gryglewski, R J. (1988) Flavonoids are Scavengers of Superoxide Anions. Biochemical Pharmacology, 37(5)
- *based on the average decline in brain performance with age. Enzogenol based supplement taken for 5 weeks in high dosage.
- GHQ: General Health Questionnaire
- Visual acuity (VA) is acuteness or clearness of vision, which is dependent on the sharpness of the retinal focus within the eye and the sensitivity of the interpretative faculty of the brain.[
- Visual acuity (VA) is acuteness or clearness of vision, which is dependent on the sharpness of the retinal focus within the eye and the sensitivity of the interpretative faculty of the brain.[
- * High dosages of Enzogenol based supplement was given. Migraine Disability Assessment Score (MIDAS)
- In vitro assays*