Presentacion bio mol

Molecular Biology – NEWS
Genome’s 3D Structure shapes how genes are expressed.
Down syndrome gene suppresed by scientists.
Maria Isabel Palacio Mejía
Medical Student in 3rd Semester
ECS – UPB. 2013 II

Cooper GM, Hausman RF. The Cell: A Molecular Approach. 3. ed. Washington,
DC, USA: ASM Press; 2007.
The histones package DNA in an ordely manner in the
nucleus of the cell, resulting chomosomes.
In molecular terms, a gene can define like a segment of
DNA, that is expressed to yeild in a final product.
Genes are composed of coding segmente (exons), wich are
separated by non-coding segments (intrones).

Genome’s 3D Structure Shapes How Genes Are Expressed [Internet]. Asian Sci. Mag. Sci.
Technol. Med. News Updat. Asia. [cited 2013 Jul 28]. Available from:
http://www.asianscientist.com/in-the-lab/genomes-3d-structure-shapes-genes-expressed-2013/
We understan relatively little about the
3D structure of the genoma.
As international team of scientists has
analysed the genome’s 3D structure of
high resolution

In this study, researchers used the vast amount
of data from the ENCODE project to infer how the
genome is folded up.
The same gene can generete different proteins.
From this analysis, found that even within a gene,
there are selected exons wich are more easily
exposed compared to others.

3D structure of the genoma can influence the wich
exons of the genes are included in the final protein
product

Different versions of the protein maybe
produced by the same gene under
different conditions, depending on the
structure of the genoma at the time.

PERSONAL OPINION
This news show us the knowledge
is in continuosly evolution, now we
know that our genetic code have a
organization form that expand the
posibility of combinations and of
course the results, this represent
new oportunities, the door of the
future.
This news show us the knowledge
is in continuosly evolution, now we
know that our genetic code have a
organization form that expand the
posibility of combinations and of
course the results, this represent
new oportunities, the door of the
future.

Down syndrome cells suppressed by scientists - Technology & Science - CBC News [Internet].
Cbcnews Technol. Sci. [cited 2013 Jul 28]. Available from:
http://www.cbc.ca/news/technology/story/2013/07/18/sci-down-syndrome-gene-suppressed.html
The University of Massachusetts Medical School say they
have found a way to supress the effect of the extra
chromosome that causes Down Syndrome.

Brings into the realm of consideration
research an the concept of “chromosome
therapy” in the future” said Jeanne
Lawrence.

Using lab-grown stem cells with
Down syndrome, Lawrence’s team
spliced in a RNA gene called Xirst,
wich normally functions to muzzle
one of the two X chromosomes
found in famale embryos.

Xist functioned to modify the structure of the estra
chromosome to desactivate most of its genes and
prevent the production of proteins and other
elements.

PERSONAL OPINION
This news shows us the
importance of research, wich blurs
the limits and allows us to advance
more and more; creating new
possibilities and become real
things that at some point were
dreams as gene therapy. It is the
biginning of new forms of
therapeutic
This news shows us the
importance of research, wich blurs
the limits and allows us to advance
more and more; creating new
possibilities and become real
things that at some point were
dreams as gene therapy. It is the
biginning of new forms of
therapeutic

MEDICAL UTILITY
This news shows
us that the
future is as big
as our
imagination
allows. This
results are
importante
because
represent the
biginning of a
new era.

MEDICAL UTILITY
The new research opens a door for
us like Doctors, for new knowlege to
understantand the human body and
with that the tools for new
intervention, in the search of better
quality of life.

MEDICAL UTILITY
Now we can talk about a new form of
gene expression, and the possibility of
a new therapeutic form that have a big
impact in the society

MEDICAL UTILITY

REFERENCES
Introduction
Cooper GM, Hausman RF. The Cell: A Molecular Approach. 3. ed. Washington,
DC, USA: ASM Press; 2007.
Genome´s 3D structure Shapes how Genes Are Expressed
Posted: July 4, 2013
Genome’s 3D Structure Shapes How Genes Are Expressed [Internet]. Asian Sci.
Mag. Sci. Technol. Med. News Updat. Asia. [cited 2013 Jul 28]. Available from:
http://www.asianscientist.com/in-the-lab/genomes-3d-structure-shapes-
genes-expressed-2013/
Down síndrome gene suppressed by scientists.
Posted: Jul 18, 2013
Down syndrome cells suppressed by scientists - Technology & Science - CBC
News [Internet]. Cbcnews Technol. Sci. [cited 2013 Jul 28]. Available from:
http://www.cbc.ca/news/technology/story/2013/07/18/sci-down-syndrome-
gene-suppressed.html

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