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Presentacion bio mol Presentacion bio mol Presentation Transcript

  • Molecular Biology – NEWS Genome’s 3D Structure shapes how genes are expressed. Down syndrome gene suppresed by scientists. Maria Isabel Palacio Mejía Medical Student in 3rd Semester ECS – UPB. 2013 II
  • Molecular Biology – NEWS
  • Molecular Biology – NEWS View slide
  • Molecular Biology – NEWS Cooper GM, Hausman RF. The Cell: A Molecular Approach. 3. ed. Washington, DC, USA: ASM Press; 2007. The histones package DNA in an ordely manner in the nucleus of the cell, resulting chomosomes. In molecular terms, a gene can define like a segment of DNA, that is expressed to yeild in a final product. Genes are composed of coding segmente (exons), wich are separated by non-coding segments (intrones). View slide
  • Molecular Biology – NEWS Genome’s 3D Structure Shapes How Genes Are Expressed [Internet]. Asian Sci. Mag. Sci. Technol. Med. News Updat. Asia. [cited 2013 Jul 28]. Available from: http://www.asianscientist.com/in-the-lab/genomes-3d-structure-shapes-genes-expressed-2013/ We understan relatively little about the 3D structure of the genoma. As international team of scientists has analysed the genome’s 3D structure of high resolution
  • Molecular Biology – NEWS Genome’s 3D Structure Shapes How Genes Are Expressed [Internet]. Asian Sci. Mag. Sci. Technol. Med. News Updat. Asia. [cited 2013 Jul 28]. Available from: http://www.asianscientist.com/in-the-lab/genomes-3d-structure-shapes-genes-expressed-2013/ In this study, researchers used the vast amount of data from the ENCODE project to infer how the genome is folded up. The same gene can generete different proteins. From this analysis, found that even within a gene, there are selected exons wich are more easily exposed compared to others.
  • Molecular Biology – NEWS Genome’s 3D Structure Shapes How Genes Are Expressed [Internet]. Asian Sci. Mag. Sci. Technol. Med. News Updat. Asia. [cited 2013 Jul 28]. Available from: http://www.asianscientist.com/in-the-lab/genomes-3d-structure-shapes-genes-expressed-2013/ 3D structure of the genoma can influence the wich exons of the genes are included in the final protein product
  • Molecular Biology – NEWS Genome’s 3D Structure Shapes How Genes Are Expressed [Internet]. Asian Sci. Mag. Sci. Technol. Med. News Updat. Asia. [cited 2013 Jul 28]. Available from: http://www.asianscientist.com/in-the-lab/genomes-3d-structure-shapes-genes-expressed-2013/ Different versions of the protein maybe produced by the same gene under different conditions, depending on the structure of the genoma at the time.
  • Molecular Biology – NEWS PERSONAL OPINION This news show us the knowledge is in continuosly evolution, now we know that our genetic code have a organization form that expand the posibility of combinations and of course the results, this represent new oportunities, the door of the future. This news show us the knowledge is in continuosly evolution, now we know that our genetic code have a organization form that expand the posibility of combinations and of course the results, this represent new oportunities, the door of the future.
  • Molecular Biology – NEWS Down syndrome cells suppressed by scientists - Technology & Science - CBC News [Internet]. Cbcnews Technol. Sci. [cited 2013 Jul 28]. Available from: http://www.cbc.ca/news/technology/story/2013/07/18/sci-down-syndrome-gene-suppressed.html The University of Massachusetts Medical School say they have found a way to supress the effect of the extra chromosome that causes Down Syndrome.
  • Molecular Biology – NEWS Down syndrome cells suppressed by scientists - Technology & Science - CBC News [Internet]. Cbcnews Technol. Sci. [cited 2013 Jul 28]. Available from: http://www.cbc.ca/news/technology/story/2013/07/18/sci-down-syndrome-gene-suppressed.html Brings into the realm of consideration research an the concept of “chromosome therapy” in the future” said Jeanne Lawrence.
  • Molecular Biology – NEWS Down syndrome cells suppressed by scientists - Technology & Science - CBC News [Internet]. Cbcnews Technol. Sci. [cited 2013 Jul 28]. Available from: http://www.cbc.ca/news/technology/story/2013/07/18/sci-down-syndrome-gene-suppressed.html Using lab-grown stem cells with Down syndrome, Lawrence’s team spliced in a RNA gene called Xirst, wich normally functions to muzzle one of the two X chromosomes found in famale embryos.
  • Molecular Biology – NEWS Down syndrome cells suppressed by scientists - Technology & Science - CBC News [Internet]. Cbcnews Technol. Sci. [cited 2013 Jul 28]. Available from: http://www.cbc.ca/news/technology/story/2013/07/18/sci-down-syndrome-gene-suppressed.html Xist functioned to modify the structure of the estra chromosome to desactivate most of its genes and prevent the production of proteins and other elements.
  • Molecular Biology – NEWS PERSONAL OPINION This news shows us the importance of research, wich blurs the limits and allows us to advance more and more; creating new possibilities and become real things that at some point were dreams as gene therapy. It is the biginning of new forms of therapeutic This news shows us the importance of research, wich blurs the limits and allows us to advance more and more; creating new possibilities and become real things that at some point were dreams as gene therapy. It is the biginning of new forms of therapeutic
  • Molecular Biology – NEWS MEDICAL UTILITY This news shows us that the future is as big as our imagination allows. This results are importante because represent the biginning of a new era.
  • Molecular Biology – NEWS MEDICAL UTILITY The new research opens a door for us like Doctors, for new knowlege to understantand the human body and with that the tools for new intervention, in the search of better quality of life.
  • Molecular Biology – NEWS MEDICAL UTILITY Now we can talk about a new form of gene expression, and the possibility of a new therapeutic form that have a big impact in the society
  • Molecular Biology – NEWS MEDICAL UTILITY
  • Molecular Biology – NEWS REFERENCES Introduction Cooper GM, Hausman RF. The Cell: A Molecular Approach. 3. ed. Washington, DC, USA: ASM Press; 2007. Genome´s 3D structure Shapes how Genes Are Expressed Posted: July 4, 2013 Genome’s 3D Structure Shapes How Genes Are Expressed [Internet]. Asian Sci. Mag. Sci. Technol. Med. News Updat. Asia. [cited 2013 Jul 28]. Available from: http://www.asianscientist.com/in-the-lab/genomes-3d-structure-shapes- genes-expressed-2013/ Down síndrome gene suppressed by scientists. Posted: Jul 18, 2013 Down syndrome cells suppressed by scientists - Technology & Science - CBC News [Internet]. Cbcnews Technol. Sci. [cited 2013 Jul 28]. Available from: http://www.cbc.ca/news/technology/story/2013/07/18/sci-down-syndrome- gene-suppressed.html
  • Molecualr Biology – NEWS