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Dr Harshal Rajekar MS MRCS DNB
Consultant hepatobiliary and transplant
surgeon, Pune
 Prometheus enraged the Gods after climbing
the Mount Olympus and stealing the torch in
order to give fire to the humans.
 He was punished by Zeus and chained to a
rock in the Kaukasus Mountains. Every
couple of days, an eagle came and ate part of
his liver.
 As the liver regenerated every time, the eagle
returned again and again to eat the liver and
thereby torture poor Prometheus.
Glisson performed extensive investigations
of the vascular anatomy in 1654.
It was more than two centuries before his
work was rediscovered and further clarified
by Rex (1888) in Germany and Cantlie
(1897) in England.
These contributions led to the division of
the liver into the present left and right lobe
as we know them.
 Langenbuch was the first to perform a
successful elective liver resection in 1887 and
Wendel did the first hemihepatectomy in
1911.
 The principles of liver haemostasis and
regeneration were determined in the period
1880-1900.
 The knowledge of the principle of inflow and
outflow of the liver and vascular control was
one of the major advancements.
 Before that, wedge resections and mattress
sutures were mostly used.
This insight of inflow and outflow reduction
was marked by the publication of James
Hogart Pringle of Glasgow, Scotland.
He described the idea of digital control of
the hilar ligament to reduce liver
haemorrhage.
In the beginning, however, blood loss and
mortality were considerable.
A multicentre analysis in 1977 of more
than 600 hepatic resections for various
indications showed an operative mortality
of 13%, which rose to 20% for major
resections
The first hepatectomy for cancer was
reported by Ichio Honjo (Kyoto University)
in 1949, and
Jean-Louis Lortat-Jacob in 1952, the
patient being a 58-year-old woman
diagnosed with colorectal cancer which
had metastasized to the liver.
Longmire, called it a "hostile" organ
because it welcomes malignant cells and
sepsis so warmly, bleeds so copiously, and
is often the 1st organ to be injured in blunt
abdominal trauma.
Yet, the liver is able to to regenerate after
massive loss of substance, and is able, in
many ways, to forgive insult.
 http://en.wikipedia.org/wiki/Hepatectomy
 http://www.soering.com/applications/liver_surgery/
 http://www.intechopen.com/books/hepatic-surgery
 http://pie.med.utoronto.ca/tvasurg/
 http://www.surgeryencyclopedia.com/Fi-La/Hepatectomy.html
 http://www.rams.umd.edu/pdf/IROS2003_1.pdf
 https://www.google.com/search?source=ig&rlz=&q=liver+tissue+stre
ngth+&oq=liver+tissue+strength+&gs_l=igoogle.3...12748.19364.0.2
1441.22.15.0.7.2.1.451.3702.3j4j1j5j2.15.0...0.0...1ac.1.12.igoogle.lq
FYwZ6pK7o#sclient=psy-
ab&q=liver+forces+tissue&oq=liver+forces+tissue&gs_l=serp.3...131
771.141026.5.144892.32.22.0.0.0.7.2886.13230.3-
5j4j2j3j1j1j1.17.0...0.0...1c.1.15.psy-
ab.nRgIfpLu0zQ&pbx=1&bav=on.2,or.r_cp.r_qf.&bvm=bv.47244034,
d.bmk&fp=b4b5f1cc27542df1&biw=1280&bih=681

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Liver surgery

  • 1. Dr Harshal Rajekar MS MRCS DNB Consultant hepatobiliary and transplant surgeon, Pune
  • 2.  Prometheus enraged the Gods after climbing the Mount Olympus and stealing the torch in order to give fire to the humans.  He was punished by Zeus and chained to a rock in the Kaukasus Mountains. Every couple of days, an eagle came and ate part of his liver.  As the liver regenerated every time, the eagle returned again and again to eat the liver and thereby torture poor Prometheus.
  • 3. Glisson performed extensive investigations of the vascular anatomy in 1654. It was more than two centuries before his work was rediscovered and further clarified by Rex (1888) in Germany and Cantlie (1897) in England. These contributions led to the division of the liver into the present left and right lobe as we know them.
  • 4.  Langenbuch was the first to perform a successful elective liver resection in 1887 and Wendel did the first hemihepatectomy in 1911.  The principles of liver haemostasis and regeneration were determined in the period 1880-1900.  The knowledge of the principle of inflow and outflow of the liver and vascular control was one of the major advancements.  Before that, wedge resections and mattress sutures were mostly used.
  • 5. This insight of inflow and outflow reduction was marked by the publication of James Hogart Pringle of Glasgow, Scotland. He described the idea of digital control of the hilar ligament to reduce liver haemorrhage.
  • 6. In the beginning, however, blood loss and mortality were considerable. A multicentre analysis in 1977 of more than 600 hepatic resections for various indications showed an operative mortality of 13%, which rose to 20% for major resections
  • 7. The first hepatectomy for cancer was reported by Ichio Honjo (Kyoto University) in 1949, and Jean-Louis Lortat-Jacob in 1952, the patient being a 58-year-old woman diagnosed with colorectal cancer which had metastasized to the liver.
  • 8. Longmire, called it a "hostile" organ because it welcomes malignant cells and sepsis so warmly, bleeds so copiously, and is often the 1st organ to be injured in blunt abdominal trauma. Yet, the liver is able to to regenerate after massive loss of substance, and is able, in many ways, to forgive insult.
  • 9.
  • 10.  http://en.wikipedia.org/wiki/Hepatectomy  http://www.soering.com/applications/liver_surgery/  http://www.intechopen.com/books/hepatic-surgery  http://pie.med.utoronto.ca/tvasurg/  http://www.surgeryencyclopedia.com/Fi-La/Hepatectomy.html  http://www.rams.umd.edu/pdf/IROS2003_1.pdf  https://www.google.com/search?source=ig&rlz=&q=liver+tissue+stre ngth+&oq=liver+tissue+strength+&gs_l=igoogle.3...12748.19364.0.2 1441.22.15.0.7.2.1.451.3702.3j4j1j5j2.15.0...0.0...1ac.1.12.igoogle.lq FYwZ6pK7o#sclient=psy- ab&q=liver+forces+tissue&oq=liver+forces+tissue&gs_l=serp.3...131 771.141026.5.144892.32.22.0.0.0.7.2886.13230.3- 5j4j2j3j1j1j1.17.0...0.0...1c.1.15.psy- ab.nRgIfpLu0zQ&pbx=1&bav=on.2,or.r_cp.r_qf.&bvm=bv.47244034, d.bmk&fp=b4b5f1cc27542df1&biw=1280&bih=681