Flu how to combat it naturally?


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AWAREmed Health and Wellness Resource Center offers to Doctors and patients alike a simple solution to combating the Flu Naturally. Using food as Medicine, Herbs and botanical as medicine, Exercise and laughter as Medicine. How to Prevent and combat the flu naturally by understanding how the viruses behave?

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Flu how to combat it naturally?

  1. 1.  INFLUENZA  Copyright  ©  2012  AWAREmed  All  Rights  Reserved.   1  
  2. 2. Influenza Disease Burden in the United States in an Average Year Deaths*   Hospitalizations*   3,000  to  49,000   117,000  to  816,000   Physician  visits   ~25  million   Infections  and  illnesses   50  to  60  million   *  All-­‐cause  hospitalization  and  mortality  associated  with  influenza  virus  infection.  Thompson WW et al. JAMA. 2003;289:179-186; Thompson WW et al. JAMA. 2004;292:1333-1340;Couch RB. Ann Intern Med. 2000;133:992-998; Patriarca PA. JAMA. 1999;282:75-77; ACIP. MMWR. 2004;53(RR06):1-40;MMWR. 2010; 59(33): 1057-1062. Copyright  ©  2012  AWAREmed  All  Rights  Reserved.  
  3. 3. South  Carolina  1996-­‐1997  DHEC  bulletin   malathia  influenzae  per  le  stelle   no  virus   CULTURE   influenza  A    RESULTS     influenza  B  Copyright  ©  2012  AWAREmed  All  Rights  Reserved.  
  4. 4. BUSINESS   Flu  Combating  Algorithm  STRATEGY   1.  Understand  Your   *Food  as  Medicine,   Enemy  –  Virus  Flu   *Herbs  as  Medicine   2.  Understand  its   strategies   Build  a  Stronger   *Exercise  as  Medicine   Immune  System.   *Sleep  as  Medicine   Enhance  the  body  own   power  and  deffence   tools  .     Use  ll  the  Natural   Love  as  Medicine   resources  ito   Laughter  asMedicine   achieve  a  safe  and   Spiritusality  as  Medicine   healthy  Winter   Copyright  ©  2012  AWAREmed  All  Rights  Reserved.  
  5. 5. FLU  Fighting  BUSINESS   Strategies  STRATEGY   Missions  and  Goals   Strategic  planning   Implementa:on     Know  Your  Enemy     Successfully  avoid  the  Flu  and   Understand  Viruses   Arm  yourself  with   remain  ealthy  and  aawell   and  all  there   the  tools  that   during  aaaaflu  aseason   behaviors  to  know   counteract  the  effect     how  to  properly   of  the  virus.       Combat  Them       1.  Food  as  Medicine,   Build  a  Stronger  Immune   1.  Understand  how  the   2.  Herbs  as  Medicine   System.   Flu  Is  transmitted   3.  Exercise  as  Medicine   Enhance  the  body  own   2.  Recognize  early   4.  Love  as  Medicine   power  and  deffence  tools   Symptoms  of  the  Flu   5.  Laughter  as  Medicine   to  combat  and  prevent  flu   6.  Spiritusality  as     Medicine     1.  Interferon  Concept   Use  ll  the  Natural   1.  Know  yor  Body   2.  Enzyme   resources  ito  achieve  a   3.  Replace  your  flora   safe  and  healthy  Winter   2.  Know  Your   4.  Healthy  PH     Friends   Copyright  ©  2012  AWAREmed  All  Rights  Reserved.  
  6. 6. How  Ca   Virus   High  Mucosal   Cigarette   Acidity   Smoke   • Viruses  like    seeds  they   Poor  Mucosal   cannot  grow  and  germinate   Altering   defense   unless  all  they  have  opZmal   Flora     condiZons   High   SuscepZbility     Flu  develops   Copyright  ©  2012  AWAREmed  All  Rights  Reserved.  
  7. 7. The  Magical  Network   Spirit  –  Body   -­‐    Mind   Internal  Body   invironment  and   Immunity     External   Environment:   O2,  Toxin     Water,  Food,   Herbs,  Sun,     Supplement   Copyright  ©  2012  AWAREmed  All  Rights  Reserved.  
  8. 8. TRANSMISSION  s  AEROSOL   s  100,000  TO  1,000,000   VIRIONS  PER  DROPLET  s  18-­‐72  HR  INCUBATION  s  SHEDDING   8  
  9. 9. Influenza: Who s at risk?s  Everybodys  People with greater risk: Ø ≥ 65 years old Ø Patients with chronic diseases Ø  Asthma/Lung chronic disease Ø  Chronic Heart Disease s  ≤ 5 years old
  10. 10. s  DECREASED   CLEARANCE  s  RISK  BACTERIAL   INFECTION  s  VIREMIA  RARE   10   Lycke  and  Norrby  Textbook  of  Medical  Virology  1983  
  12. 12. interferon-­‐alpha,  interferon-­‐beta   interferon  receptor     induction  of     induction  of     induction  of  a   2ʼ’5ʼ’oligo  A  synthase   ribonuclease  L     protein  kinase    ds  RNA   2ʼ’5ʼ’oligo  A   ds  RNA   activated   activated     activated   2ʼ’5ʼ’oligo  A  synthase   ribonuclease  L     protein  kinase     ATP   ATP   phosphorylated  initiation   2ʼ’5ʼ’oligo  A   factor  (eIF-­‐2)   mRNA  degraded     inhibition  of  protein  synthesis     12  
  13. 13. ORTHOMYXOVIRUSES   HA  -­‐  hemagglutinin       NA  -­‐  neuraminidase   helical  nucleocapsid  (RNA  plus     NP  protein)           lipid  bilayer  membrane     polymerase  complex   M1  protein  type  A,  B,  C  :  NP,  M1  protein        sub-­‐types:  HA  or  NA  protein   13  
  14. 14. ORTHOMYXOVIRUSES  pleomorphic  influenza  types  A,B,C  febrile,  respiratory  illness   with  systemic   symptoms     http://www.uct.ac.za/depts/mmi/stannard/fluvirus.html   14  
  15. 15. CAUSE:      RNA  Virus   s  file:///Users/outreach/ s         The  influenza  virus,   Desktop/DESKTOP commonly  known  as  the   %202008/curr flu,  is  an  infectious   %20project/Image-­‐3D disease  of  birds  and   %20Influenza%20virus   mammals  caused  by  RNA   viruses.    Commonly   confused  with  a  cold,  the   flu  is  a  much  more   severe  disease  and  http://en.wikipedia.org/wiki/Image:3D_Influenza_virus.png  caused  by  a  different   virus.  
  16. 16. Key Influenza A Viral Features Two Surface proteins(major antigens) s  Hemagglutinin (HA) HA s  Site of attachment to host cells •  Antibody to HA is protective s  Neuraminadase (NA) •  Helps release virions from cells NA Antibody to NA can help modify disease •  17 severity
  17. 17. INFLUENZA  A  PANDEMICS   19  
  18. 18. Type A influenza 16 HA subtypescannot be eradicated 9 NA subtypes α2-6Gal α2-3Gal α2-3Gal α2-6Gal α2-3Gal α2-6Gal
  19. 19. where  do   new  HA  and  NA   come  from?  s  13  types  HA  s     9  types  NA   s  all  circulate  in  birds  s  pigs   s  avian  and  human   21  
  20. 20. where  do   new  HA  and  NA   come  from?   22  
  21. 21. Reassortment
  22. 22. Pandemic Influenza 2009 - Natural history of swine influenza North American Swine Influenza Eurasian Swine Influenza (~last 12 years) trH3N2 trH3N2 cH1N1   trH1N2 H3N2 cH1N1   trH1N1 PB2 = North Am. Avian H1N1 PB1 = Human PA = North Am. Avian PB2 = H3N2 swine HA = Human PB1 = H3N2 swine 2009 swine-like H1N1 NP = Classical swine PA = H3N2 swine American flu NA = Human HA = Classical swine M = Classical swine NP = Classical swine NS = Classical swine NA = Eurasian swine M = Eurasian swine NS = Classical swine
  23. 23. 1918 H1N1 Spanish flu >20 million deaths 1957 H2N2 Asian FluPandemic influenza strains contain ~2 million deaths genes from the avian reservoir 1968 H3N2 Hong Kong Flu ~700,000 deaths 1977 ? H1N1 Russian Flu 2009 H1N1 American Flu
  24. 24. Neuraminidase InhibitorsSurface glycoprotein genes “Tamiflu” “Relenza” HA and NA X Release HA NA Master donor ER - Golgi strain genes AAAA   PB2 PB1 PA AAAA   AAAA   NP M NS Packaging and Budding Transfection of plasmids into cells Nucleus AAAA   X IFN   AAAA   Host mRNAs Receptor binding and Entry Uncoating Amantadine X+ H Endocytosis “Symmetrel” “Flumadine”
  25. 25. Influenza virus Reverse Genetics viral protein translation cap AAAA mRNARNA polymerase II (pol II) pIICMV pABGH ATG--------- viral cDNA -------TAA tI pIh RNA polymerase I (pol I) (-) vRNA ppp 3‘ 5‘
  26. 26. why  do  we  not  have  influenza   B  pandemics?        s  so  far  no  shifts  have   been  recorded  s  no  animal  reservoir   known   28  
  27. 27. Spreading  
  28. 28. Fig.  13.11  
  29. 29. Anatomy  of  Nose  and  Sinuses  
  30. 30. Anatomy  of  Nose  &  Sinuses,   cont.  
  31. 31. Fusion Schematic Fusion  Schematic   1)  HA  binds  a  cell  GP  at  a   Sialic  Acid  Binding  Site   http://ubik.microbiol.washington.edu/microm-­‐pabio445/MM_445_lec3_2002_files/MM_445_lec3_2002.ppt  
  32. 32. Fusion Schematic Fusion  Schematic   1)  HA  binds  a  cell  GP  at  a   Sialic  Acid  Binding  Site   Low  pH   2)  Clathrin-­‐Coated  pit   endocytoses  virion   http://ubik.microbiol.washington.edu/microm-­‐pabio445/MM_445_lec3_2002_files/MM_445_lec3_2002.ppt  
  33. 33. Fusion Schematic Fusion  Schematic   1)  HA  binds  a  cell  GP  at  a   Sialic  Acid  Binding  Site   3)  Conformational  Change:   Hydrophobic  binding  of  HA   to  vesicle  membrane   Low  pH   2)  Clathrin-­‐Coated  pit   endocytoses  virion   http://ubik.microbiol.washington.edu/microm-­‐pabio445/MM_445_lec3_2002_files/MM_445_lec3_2002.ppt  
  34. 34. Fusion Schematic Fusion  Schematic   1)  HA  binds  a  cell  GP  at  a   Sialic  Acid  Binding  Site   3)  Conformational  Change:   Hydrophobic  binding  of  HA   to  vesicle  membrane   Low  pH   2)  Clathrin-­‐Coated  pit   endocytoses  virion   4)  RNPs  are  released  into   cytoplasm  for  replication   and  transcription  (vRNA  and   mRNA)   http://ubik.microbiol.washington.edu/microm-­‐pabio445/MM_445_lec3_2002_files/MM_445_lec3_2002.ppt  
  35. 35. Cellular  targets  B)  Inhibitors  of  cellular  factors  that  regulate  the  virus  life  cycle       Hillaire  et  al.  (P-­‐452)  Collectin  pSP-­‐D   Nicol  et  al.  (P-­‐449)  FLUPEP   DAS181 Budding   Adsorption   " Packaging   Entry Posttranslational Actin Processing Rab 11 Endocytosis Translation   Rabs, V-type ATPases PKC Fusion and Release   RNP- mRNA   Export vRNA (-)   CRM1 Hsc70 Import Importins cRNA (+)   NUP153 NUPs
  36. 36. Cellular  targets   Viral  penetration  of  cellular  barriers  is  controlled     by  cellular  signaling  cascades   Budding   Adsorption  RTKs (e.g. EGFR)Eierhoff et al. (2010)PLoS Pathog (in press) Packaging   PI3K Posttranslational Raf/MEK/ERK Processing Entry Pleschka et al. (2001) Nat Ce Endocytosis Translation   IKK/NF-kB Wurzer et al. (2004) Cell Micr Wurzer et al. (2003) EMBO J. Fusion and Release   RNP- mRNA   Export vRNA (-)   Import cRNA (+)  
  37. 37. INTERFERON   41  
  38. 38. INTERFERON   antiviral  state  antiviral  state   antiviral  state   antiviral  state   42  
  39. 39. INTERFERON   antiviral  state  antiviral  state   antiviral  state   antiviral  state   43  
  40. 40. INTERFERON   antiviral  state  antiviral  state   antiviral  state   antiviral  state   44  
  41. 41. INTERFERON  THE  VIRUSES  ARE  COMING!   PAUL  REVERE   http://www.mfa.org/collections/one_hour/6.htm   45   http://www.paulreverehouse.org/midnight.html  
  42. 42. Echinecea  
  43. 43. Elder  Berry  
  44. 44. Fruits  
  45. 45. Garlic  
  46. 46. Bee  Propolis  
  47. 47. Olive  Leaf  
  48. 48. Education  and  Awareness  s  Consult their physician before taking other medication, including OTCss Good hygienes Antiviral drugs are not cures but help manage symptoms