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Many GO terms are  implicitly  composite ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Opaque references to other  OBO  ontologies ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Methodology ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object]
GO: now is_a GABA  biosynthesis GABA  metabolism amino acid  biosynthesis amino acid  metabolism GO
GO+ChEBI: now is_a GABA  biosynthesis GABA  metabolism amino acid  biosynthesis amino acid  metabolism GO amino acid GABA ChEBI
Linking GO to ChEBI is_a GABA  biosynthesis GABA  metabolism amino acid  biosynthesis amino acid  metabolism GO amino acid GABA ChEBI
Can we find missing links? is_a GABA  biosynthesis GABA  metabolism amino acid  biosynthesis amino acid  metabolism GO amino acid GABA ChEBI
Checking consistency ,[object Object],[object Object]
Simple DAGs are not enough ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Example genus-differentia definition ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[Term] id: GO:0009447 name: putrescine catabolic process intersection_of: GO:0009056 ! catabolism intersection_of: results_in_division_of CHEBI:17148 ! putrescine [Term] id: GO:0009448 name: gamma-aminobutyric acid metabolic process intersection_of: GO:0008152 ! metabolism intersection_of: has_participant CHEBI:16865 ! gamma-aminobutyric acid [Term] id: GO:0009449 name: gamma-aminobutyric acid biosynthetic process intersection_of: GO:0009058 ! biosynthesis intersection_of: results_in_change_to CHEBI:16865 ! gamma-aminobutyric acid [Term] id: GO:0009450 name: gamma-aminobutyric acid catabolic process intersection_of: GO:0009056 ! catabolism intersection_of: results_in_division_of CHEBI:16865 ! gamma-aminobutyric acid
Results ,[object Object],[object Object],[object Object],[object Object]
[Term] id:  anon_chemical_16 namespace: chebi_ontology is_anonymous: true union_of: CHEBI:27775 ! P(1),P(3)-bis(5'-adenosyl)  triphosphate union_of: CHEBI:27529 ! P(1),P(2)-bis(5'-adenosyl)  triphosphate [Term] id: anon_chemical_17 namespace: chebi_ontology is_anonymous: true union_of: CHEBI:16019 ! prenol union_of: CHEBI:26244 ! prenols [Term] id: anon_chemical_18 namespace: chebi_ontology is_anonymous: true union_of: CHEBI:28266 ! fluorene union_of: CHEBI:24059 ! fluorenes [Term] id: anon_chemical_19 namespace: chebi_ontology is_anonymous: true union_of: CHEBI:17563 ! phthalate(2-) union_of: CHEBI:30800 ! phthalate(1-) [Term] id: GO:0015962 name: diadenosine triphosphate metabolic process intersection_of: GO:0008152 ! metabolism intersection_of: has_participant  anon_chemical_16

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Gene Ontology & ChEBI -- cross products

  • 1.
  • 2.
  • 3.
  • 4.
  • 5. GO: now is_a GABA biosynthesis GABA metabolism amino acid biosynthesis amino acid metabolism GO
  • 6. GO+ChEBI: now is_a GABA biosynthesis GABA metabolism amino acid biosynthesis amino acid metabolism GO amino acid GABA ChEBI
  • 7. Linking GO to ChEBI is_a GABA biosynthesis GABA metabolism amino acid biosynthesis amino acid metabolism GO amino acid GABA ChEBI
  • 8. Can we find missing links? is_a GABA biosynthesis GABA metabolism amino acid biosynthesis amino acid metabolism GO amino acid GABA ChEBI
  • 9.
  • 10.
  • 11.
  • 12. [Term] id: GO:0009447 name: putrescine catabolic process intersection_of: GO:0009056 ! catabolism intersection_of: results_in_division_of CHEBI:17148 ! putrescine [Term] id: GO:0009448 name: gamma-aminobutyric acid metabolic process intersection_of: GO:0008152 ! metabolism intersection_of: has_participant CHEBI:16865 ! gamma-aminobutyric acid [Term] id: GO:0009449 name: gamma-aminobutyric acid biosynthetic process intersection_of: GO:0009058 ! biosynthesis intersection_of: results_in_change_to CHEBI:16865 ! gamma-aminobutyric acid [Term] id: GO:0009450 name: gamma-aminobutyric acid catabolic process intersection_of: GO:0009056 ! catabolism intersection_of: results_in_division_of CHEBI:16865 ! gamma-aminobutyric acid
  • 13.
  • 14. [Term] id: anon_chemical_16 namespace: chebi_ontology is_anonymous: true union_of: CHEBI:27775 ! P(1),P(3)-bis(5'-adenosyl) triphosphate union_of: CHEBI:27529 ! P(1),P(2)-bis(5'-adenosyl) triphosphate [Term] id: anon_chemical_17 namespace: chebi_ontology is_anonymous: true union_of: CHEBI:16019 ! prenol union_of: CHEBI:26244 ! prenols [Term] id: anon_chemical_18 namespace: chebi_ontology is_anonymous: true union_of: CHEBI:28266 ! fluorene union_of: CHEBI:24059 ! fluorenes [Term] id: anon_chemical_19 namespace: chebi_ontology is_anonymous: true union_of: CHEBI:17563 ! phthalate(2-) union_of: CHEBI:30800 ! phthalate(1-) [Term] id: GO:0015962 name: diadenosine triphosphate metabolic process intersection_of: GO:0008152 ! metabolism intersection_of: has_participant anon_chemical_16

Editor's Notes

  1. orthogonal domains which do not fit into GO’s 3 axes (for the sake of brevity we omit discussion about intra-GO cross-products )