The positive symptoms mostly lead the patient to hospitalization & family disturbance,while negative symptoms interfere with patient being able to have close friends, maintain employment, there by contributing to the morbidity (disability) & economic cost of schizophrenia.
Once referred to have as major tranquilizers. Antipsychotic have a selective specific effect in minimizing psychotic drugs produce less severe effect-pyramidal side-effects .
These newer agents like clozapine influence dopamine receptors as well as serotin (5-HT2) receptors
Typical antipsychotics are potent d2-blockers while atypical have less d2-blockers but grater 5-ht2 blocked. That treat positive symptoms.
A typical anti psychotics treat positive & negative symptoms with minimal extra pyramidal effect. Local potency drug have potent antihistaminic, antimyscarinic & alpha-adrenergic blockage.
Eg: phenothiazines:-aliphatic piperidine
The frequent treatment includes
Emesis:The act of vomiting is produced by a series of coordinated changes in G-I activity and in respiratory movements. Nausea and vomiting may occur in: cancer; cancer chemotherapy; radiation therapy; gastroenteritis.
Gastric lavage: the washing out of the stomach with sterile water or a saline solution. The procedure is performed before and after surgery to remove irritants or toxic substances and possibly before such examinations as endoscopy or gastroscopy.
Activated charchol: That's how powerful activated charcoal is as an emergency decontaminant in the gastrointestinal (GI) tract, which includes the stomach and intestines. Activated charcoal is considered to be the most effective single agent available.
Cathersis: A catharsis is an emotional release. According to psychodynamic theory, this emotional release is linked to a need to release unconscious conflicts.