Alzforum Benzinger

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Leaky Blood-Brain Barrier a Harbinger of Alzheimer s Disease - presentation made at Alzforum's live webinar of February 17, 2015. See details at: http://www.alzforum.org/webinars/leaky-blood-brain-barrier-harbinger-alzheimers

Health & Medicine

Tammie Benzinger, MD, PhD
Imaging the blood brain barrier

Imaging the blood brain barrier
• Blood brain barrier breakdown
– Stroke
– Brain tumors
– Multiple sclerosis
– Aging
– Alzheimer’s disease

Imaging the blood brain barrier
• Computed tomography (CT)
– Dynamic perfusion, iodinated contrast
• Magnetic resonance imaging (MRI)
– Arterial spin labelling (ASL)
– Gadolinium-based
• Dynamic contrast enhancement (DCE)
• Dynamic susceptibility contrast (DSC)

Imaging the blood brain barrier
• Positron emission tomography (PET)
– FDG
– O15
– Amyloid tracers

Divergent or convergent pathologies?
• Hippocampal sclerosis?
• AD
– Amyloid & tau imaging
– CSF measures
• Other dementias?
• Breakthrough technology – can be
streamlined for clinical trials and patients in
the future

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