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Angiogenesis and Direct Myocardial Revascularization 3. Preclinical Models and Experience to Date 부산의학전문대학원 한성필 [email_address]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
General Outline ,[object Object],[object Object],[object Object],[object Object]
Preclinical efforts 어떻게  Treat 할 것인가 ? How do we treat 어떤 동물 ,  어느 경로 ,  어떤 농도 Treat 한 뒤 효과를 어떻게 포착 , 응용할 것인가 ? How do we capture the treatment effect CT, USG, MRI,  혈청학 ,  조직학 ,  형태학
I. ANIMAL MODEL SELECTION CRITERIA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
[object Object]
II. MODELS OF MYOCARDIAL ISCHEMIA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Myocardial Ischemia or Infarction ,[object Object],[object Object],[object Object],[object Object]
Ameroid Constrictor Model
Ameroid Constrictor Model
Ameroid Constrictor Model ,[object Object],[object Object],[object Object],[object Object]
Ameroid Constrictor Model ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Minimally Invasive Coronary Stenosis Model for Imaging ,[object Object],[object Object],[object Object],[object Object]
Variation of Vineberg Direct Arterial Implantation Procedure ,[object Object],[object Object]
 
Microembolization Model ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Myocardial Infarction (Ligation) Model ,[object Object],[object Object],[object Object],[object Object],[object Object]
III. HINDLIMB ISCHEMIA MODEL ,[object Object],[object Object],[object Object],[object Object],[object Object]
Ariana G. Ojalvo, “Therapeutic angiogenesis following intramuscular gene transfer of vascular endothelialgrowth factor 121 in a dog model of hindlimb ischemia,”  Electronic Journal of Biotechnology I  6, no. 3 (December 15, 2003)
세가지 치료적 접근법 ProteinTherapy 1 2 Gene Therapy 3 Cell Therapy
IV. EXPERIENCE IN PROTEIN THERAPY ,[object Object],[object Object],[object Object]
 
 
V. UPDATE IN GENE THERAPY ,[object Object],[object Object],[object Object],[object Object],[object Object]
Intramyocardial Injection Via Thoracotomy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Catheter-Based Transendocardial Injection ,[object Object],[object Object],[object Object],[object Object]
Intracoronary Delivery ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
VI. CELL THERAPY STUDIES ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
VII. NONINVASIVE IMAGING TECHNIQUES ,[object Object],[object Object],[object Object]
VIII. COLLATERAL-SENSITIVE MRI IN SWINE MODEL OF CHRONIC ISCHEMIA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
IX. ELECTROMECHANICAL LV MAPPING/INJECTION SYSTEM ,[object Object],[object Object],[object Object],[object Object]
X. ANIMAL MODELS FOR ANGIOGENESIS:DEPENDABLE BASIS FOR HUMAN STUDIES? ,[object Object],[object Object],[object Object],[object Object],[object Object]
XI. CONCLUSIONS ,[object Object],[object Object],[object Object]
감사합니다 . ,[object Object],[object Object],[object Object]

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Angiogenesis And Direct Myocardial Revascularization Changed

  • 1. Angiogenesis and Direct Myocardial Revascularization 3. Preclinical Models and Experience to Date 부산의학전문대학원 한성필 [email_address]
  • 2.
  • 3.
  • 4.
  • 5. Preclinical efforts 어떻게 Treat 할 것인가 ? How do we treat 어떤 동물 , 어느 경로 , 어떤 농도 Treat 한 뒤 효과를 어떻게 포착 , 응용할 것인가 ? How do we capture the treatment effect CT, USG, MRI, 혈청학 , 조직학 , 형태학
  • 6.
  • 7.  
  • 8.
  • 9.
  • 10.
  • 13.
  • 14.
  • 15.
  • 16.
  • 17.  
  • 18.
  • 19.
  • 20.
  • 21. Ariana G. Ojalvo, “Therapeutic angiogenesis following intramuscular gene transfer of vascular endothelialgrowth factor 121 in a dog model of hindlimb ischemia,” Electronic Journal of Biotechnology I 6, no. 3 (December 15, 2003)
  • 22. 세가지 치료적 접근법 ProteinTherapy 1 2 Gene Therapy 3 Cell Therapy
  • 23.
  • 24.  
  • 25.  
  • 26.
  • 27.
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