Systemic lupus erythematosus (SLE) is a chronic inflammatory disease that affects multiple organs. Common symptoms include fatigue, fever, arthritis, mouth ulcers, and a butterfly-shaped rash on the face. SLE is diagnosed based on 11 criteria including specific rashes, joint pain, organ inflammation, and blood abnormalities. While there is no cure for SLE, treatment focuses on reducing inflammation and protecting organs using medications like NSAIDs, corticosteroids, and hydroxychloroquine. The goal is to relieve symptoms and decrease disease activity.