systemic lupus erythematosus


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Oral Diagnosis I
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systemic lupus erythematosus

  1. 1. systemic lupus erythematosus Done by: Abdulaziz alwarthan Abdulaziz aldossari Abdulaziz alshamlan Ajebee jugdmi Ali alshammari
  2. 2. What is systemic lupus erythematosus (SLE)? Is a chronic inflammatory disease of unknown cause affecting skin, joints, kidneys, nervous system, serous membranes, and often other organ of body .
  3. 3. -When internal organs are involved, the condition is called systemic lupus erythematosus (SLE). -Systemic lupus are more common in women than men. -The disease can affect all ages but most commonly begins from age 20 to 45 years.
  4. 4. What causes lupus? -That causes of (SLE) are unknown. -Exposure to sunlight or ultraviolet radiation, viruses often leads to appearance of facial butterfly rash or rash on other exposed skin.
  5. 5. -Many other factors, including infections, inherited genes, surgery, and certain drugs, have been shown to be associated with SLE . -In females, endocrine factors have been thought to influence the development of SLE .
  6. 6. What are the symptoms of lupus? Fatigue. Fever. Weight loss. Muscle aches. Arthritis. Ulcers of the mouth and nose. Butterfly rash. Unusual sensitivity to sunlight . Inflammation of the lining that surrounds the lung and the heart . And poor circulation to the fingers and toes with cold exposure.
  7. 7. -More serious organ involvement with inflammation occurs in the brain, liver, and kidney. -White blood cells and blood clotting factors also can be decreased in SLE, thereby increasing the risk of infection and bleeding.
  8. 8. How is lupus diagnosed? The eleven criteria used for diagnosing systemic lupus erythematosus are: -Malar ( over the cheeks of the face ). -discoid skin rash: patchy redness that can cause scarring.
  9. 9. - photosensitivity: skin rash in reaction to sunlight exposure. -mucus membrane ulcers: ulcers of the lining of the mouth, nose or throat. -arthritis: 2 or more swollen, tender joints of the extremities.
  10. 10. -inflammation of the lining tissue around the heart or lungs, usually associated with chest pain with breathing . -kidney abnormalities: abnormal amounts of urine protein . -brain irritation: manifested by seizures .
  11. 11. -blood count abnormalities: low counts of white or red blood cells, or platelets . -immunologic disorder . -antinuclear antibody.
  12. 12. How is systemic lupus treated? -There is no permanent cure for SLE. -The goal of treatment is to relieve symptoms and protect organs by decreasing inflammation and/or the level of autoimmune activity in the body. -Patients with SLE need more rest during periods of active disease .
  13. 13. Nonsteroidal anti-inflammatory drugs: (NSAIDs) are helpful in reducing inflammation and pain in muscles, joints, and other tissues . (NSAIDs are usually taken with food to reduce side effects) for Example: aspirin
  14. 14. Corticosteroids: Are more potent than NSAIDs in reducing inflammation and restoring function when the disease is active. -Corticosteroids are particularly helpful when internal organs are involved.
  15. 15. Hydroxychloroquine: -effective for SLE patients with fatigue, skin, and joint disease.