Important for students in the University to study about this on the Environmental Health courses.

1. Aedes aegypti Toll Pathway
Controls Dengue Virus
ID:S160584
Name: Filisi ‘Ufi
(1)

2. Tips to be Covered
Introduction
Results
Discussions
Conclusions
References

3. Introduction
Aedes aegypti – transmit Dengue virus.
Infected blood meal from infected mosquito.
Mosquito immune system.
Infection with the virus result and control.
Limit infection with the virus.
Role of mosquito’s natural microbial flora.(2)

4. Results
Global transcriptome to dengue
 physiological of Aedes aegypti to systemic using genome-wide
transcriptional profiling approach.
 Functional classification of different genes in dengue-infected midgut
and carcass.
Immune responses to dengue infection
 Putative Immune genes regulate by virus infection in carcass and midgut
tissues
 Immune functions such as PRRs, signaling modulation, transduction,
effector systems and apoptosis.(2)

5. Con’t
Toll pathway involved anti-dengue defense
 Tested of Caspar and Cactus gene in midgut.
 Infection of mosquitoes with dengue virus induces Toll pathway then
exerts an anti-dengue effect.
Dengue infection influences
 mosquito’s endogenous bacterial flora (2)

6. Discussion
Ae.aegypti mosquito responses to dengue.
Activation of Toll pathway.
Support future experiments to defense against
dengue virus infection in Ae.aegypti.(2)

7. Conclusion
Role of Toll pathway to dengue virus in
Ae.aegypti.
Mosquito’s natural micro biota role’s in
modulating dengue virus infection.(2)

8. Reference
1. Aedes [Internet]. Wikipedia. 2016 [cited 31 May
2016]. Available from:
https://en.wikipedia.org/wiki/Aedes
2. Xi Z, Ramirez J, Dimopoulos G. The Aedes aegypti
Toll Pathway Controls Dengue Virus Infection.
PLoS Pathogens. 2008;4(7):e1000098.

9. Any Question???