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   Melaena – the passage of black, tarry stools
    indicates likely UGI bleed (proximal to the
    ligament of Treitz)

   Haematemesis – vomitus containing frank blood
    or brown-black “coffee grounds”

   Haematochezia – passage of bright or dark red
    blood per rectum
    In general, the redder the blood, the more
    distal the site of bleeding
 Red:   beets, laxatives, phenytoin, rifampin




 Black:
       bismuth, activated
 charcoal, iron, spinach, blueberry, licorice
 Drugs
 Retching   or vomiting
 Jaundice
 Procedures
 Recurrent abdominal pain
 Bleeding disorders in family
 Odynophagia
 Stigmata   of chronic liver disease

 General    condition

 External   vascular malformation

 Hyperpigmented     lips

 Dilated   abdominal wall veins, Splenomegaly
 Removes blood from stomach – facilitates
 easier endoscopy

 Confirmation   of bleed/ongoing blood loss

 Prevents development of encephalopathy in
 cirrhotic patients
 Disproportionate    tachycardia

 “Tilt”   test

 Capillary   refill time

 Signs   of shock
 Portal   vein agenesis, atresia, stenosis

    Portal vein thrombosis or cavernous
    transformation

 Splenic   vein thrombosis

   Arteriovenous fistula
 Acts   by increasing splanchnic vascular tone

 0.3
    units per kg per hour after a bolus of 0.3
 U/kg over 20 min

 Theaddition of nitroglycerin (skin patch)
 decreases the systemic .effects of
 vasopressin

 Terlipressin-longer duration of action and
 lesser cardiac side effects
 much better side-effect profile and similar
 efficacy

3   to 5 μg per kg per hour

 Octreotide has a longer half-life- bolus (2
 μg/kg) followed by continuous infusion (1 to
 5 μg per kg per hour)
 antibioticprophylaxis directed at intestinal
 flora (third-generation cephalosporin) should
 be started from admission

 H2receptor blocker or proton pump inhibitor
 intravenously
 Acts   by producing intimitis

 Injected   either intra- or paravariceal

 Intravariceal
             cyanoacrylate or histacryl glue
 and thrombin for gastric varices

 Complications of EST include
 ulceration, pain, perforation, and
 bacteremia.
 Draws a visible varix into the lumen of the
 ligator and a band is placed around the varix

 EVLis just as effective as EST but was
 associated with fewer complications and
 faster obliteration of varices.
 Indications:
 Recurrent variceal hemorrhage
 Refractory ascites
 Hepatorenal syndrome


 Contraindications
 Polycystic liver disease
 Right heart failure
 Systemic infection
 Portal vein thrombosis
 Severe hepatic encephalopathy
 Primary    prophylaxis - propranolol

 Secondary    prophylaxis – EVL/EST

 Surgical treatment:
 Patients with EHPVO
 bleeding gastric or other nonesophageal
  varices
 severe hypersplenism
 Decompressive   shunts
 Devascularization
 Liver transplantation
Upper GI bleeding & portal hypertension in Children
Upper GI bleeding & portal hypertension in Children
Upper GI bleeding & portal hypertension in Children

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Upper GI bleeding & portal hypertension in Children

  • 1.
  • 2.
  • 3. Melaena – the passage of black, tarry stools indicates likely UGI bleed (proximal to the ligament of Treitz)  Haematemesis – vomitus containing frank blood or brown-black “coffee grounds”  Haematochezia – passage of bright or dark red blood per rectum In general, the redder the blood, the more distal the site of bleeding
  • 4.  Red: beets, laxatives, phenytoin, rifampin  Black: bismuth, activated charcoal, iron, spinach, blueberry, licorice
  • 5.
  • 6.
  • 7.
  • 8.
  • 9.
  • 10.
  • 11.
  • 12.  Drugs  Retching or vomiting  Jaundice  Procedures  Recurrent abdominal pain  Bleeding disorders in family  Odynophagia
  • 13.  Stigmata of chronic liver disease  General condition  External vascular malformation  Hyperpigmented lips  Dilated abdominal wall veins, Splenomegaly
  • 14.
  • 15.  Removes blood from stomach – facilitates easier endoscopy  Confirmation of bleed/ongoing blood loss  Prevents development of encephalopathy in cirrhotic patients
  • 16.  Disproportionate tachycardia  “Tilt” test  Capillary refill time  Signs of shock
  • 17.
  • 18.
  • 19.
  • 20.  Portal vein agenesis, atresia, stenosis  Portal vein thrombosis or cavernous transformation  Splenic vein thrombosis  Arteriovenous fistula
  • 21.
  • 22.  Acts by increasing splanchnic vascular tone  0.3 units per kg per hour after a bolus of 0.3 U/kg over 20 min  Theaddition of nitroglycerin (skin patch) decreases the systemic .effects of vasopressin  Terlipressin-longer duration of action and lesser cardiac side effects
  • 23.  much better side-effect profile and similar efficacy 3 to 5 μg per kg per hour  Octreotide has a longer half-life- bolus (2 μg/kg) followed by continuous infusion (1 to 5 μg per kg per hour)
  • 24.  antibioticprophylaxis directed at intestinal flora (third-generation cephalosporin) should be started from admission  H2receptor blocker or proton pump inhibitor intravenously
  • 25.  Acts by producing intimitis  Injected either intra- or paravariceal  Intravariceal cyanoacrylate or histacryl glue and thrombin for gastric varices  Complications of EST include ulceration, pain, perforation, and bacteremia.
  • 26.  Draws a visible varix into the lumen of the ligator and a band is placed around the varix  EVLis just as effective as EST but was associated with fewer complications and faster obliteration of varices.
  • 27.
  • 28.
  • 29.  Indications:  Recurrent variceal hemorrhage  Refractory ascites  Hepatorenal syndrome  Contraindications  Polycystic liver disease  Right heart failure  Systemic infection  Portal vein thrombosis  Severe hepatic encephalopathy
  • 30.  Primary prophylaxis - propranolol  Secondary prophylaxis – EVL/EST  Surgical treatment:  Patients with EHPVO  bleeding gastric or other nonesophageal varices  severe hypersplenism
  • 31.  Decompressive shunts  Devascularization  Liver transplantation

Editor's Notes

  1. Curling’s ulcer Cushing’s ulcer Dieulafoy lesion watermelon stomach