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Arthritis

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Arthritis is a common problem in winter and in the daily lives of many across the globe. Presenting here few natural medicine for healing and relief from painful moments

Arthritis is a common problem in winter and in the daily lives of many across the globe. Presenting here few natural medicine for healing and relief from painful moments

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  • 1. Presented by Dr. Sudhakar Kokate Director PPRC, India
  • 2. About disease ∞ Inflammation of a joint characterised by pain, swelling and limitation of a joint movement ∞ Osteo-arthritia (OA) – Knee and hip…debilitating disease affected – More in women than male – Increases with ageing PPRC/INDIA 01
  • 3. About disease ∞ Rheumatoid arthritis (RA) - Most common disease - Affects 1% of world population - Involves many joints PPRC/INDIA 02
  • 4. About disease PPRC/INDIA 03
  • 5. Drugs in Practice ∞ Non-steroidal anti-inflammatory drugs (NSAIDS) …. For symptomatic treatment of OA and RA Side effects risk in use - many limitations PPRC/INDIA 04
  • 6. Side effects of NSAIDS drugs ∞ Propensity to cause stomach ulcers - GI bleeding - Perforations ∞ New cox – 2 drugs - Long term use may increase the risk of stroke and heart attack PPRC/INDIA 05
  • 7. Side effects of NSAIDS drugs ∞ USFDA withdrawn from market ∞ Biologics drugs (Anti-bodies for IL-1, IL-6, TNF-ɑ) Benefits: - Reduce inflammation - Joint destruction PPRC/INDIA 06
  • 8. Disadvantages ∞ Not effective universally ∞ Higher costs ∞ Severe side effects as life – threatening infections ∞ Increases risk of malignances PPRC/INDIA 07
  • 9. Emerging CAM therapy ∞ CAM: Complementary and Alternative Medicine ∞ Use of accu-puncture ∞ 60-90% of dissatisfied patients use this therapy PPRC/INDIA 08
  • 10. Symptoms of Arthritis ∞ Caused due to the aggravation of vata (air) dosha and accumulation of Ama (toxins) gets deposited in the weak areas of the body ∞ Weak digestion, constipation, overeating and little physical activity PPRC/INDIA 09
  • 11. Osteoarthritis ∞ Most common joint disease ∞ Women >55 yrs age affected ∞ 12% incidences of Osteoarthritis in India ∞ Condition of synovial joints characterised by cartilage loss with peri-articular response PPRC/INDIA 10
  • 12. Emerging new trends in the development of PhytoDrugs In Arthritis PPRC/INDIA 11
  • 13. Ashwagandha Withania somnifera PPRC/INDIA 12
  • 14. Withania somnifera • The root contains traces of an essential oil • It is effective in the treatment of rheumatic infections • The water soluble portion of the root extract contains indefinite amorphous substances and a quantity of sugar PPRC/INDIA 13
  • 15. Ajwain Trachyspermum ammi PPRC/INDIA 14
  • 16. Trachyspermum ammi • The seeds are used as a household remedy for indigestion, colic, diarrhoea, flatulence and asthma • In arthritis it is quite effective • Ref. The Ayurvedic Pharmacopoeia of India, New Delhi Part I, Vol. I, II • Waltis T.E. - Textbook of Pharmacogney PPRC/INDIA 15
  • 17. Alfalfa Medicago sativa PPRC/INDIA 16
  • 18. Medicago sativa • It contains 1-canavanine, an amino acid causes curing properties against joint pain PPRC/INDIA 17
  • 19. Angelica Angelica archangelica PPRC/INDIA 18
  • 20. Angelica archangelica • It is used in European folk medicine • Western variety has 12 anti-inflammatory constituents, 10 anti-spasmodic constituents and 5 anodyne ones • Chinese species is sold in North America in the name of dang guei or dang quai PPRC/INDIA 19
  • 21. Black cohosh Cimicifuga racemosa PPRC/INDIA 20
  • 22. Cimicifuga racemosa • There are five species worldwide that have been used to treat rheumatism • It contains aspirin-like substances and the root of the plant is very beneficial • Other anti-inflammatory and anti-spasmodic constituents PPRC/INDIA 21
  • 23. Celery Apium graveolens PPRC/INDIA 22
  • 24. Apium graveolens • Eating raw or cooked celery seeds or large amount of this plant to treat rheumatism arrived in North America • Celery is rich in minerals • 1 cup of celery contains 350 mg of potassium PPRC/INDIA 23
  • 25. Chaparral Larrea tridentata PPRC/INDIA 24
  • 26. Larrea tridentata • It is widely promoted in health food-stores as a treatment for arthritis • Externally as a wash or internally as a tea PPRC/INDIA 25
  • 27. Cat’s claw Uncaria tomentosa, Uncaria guianensis PPRC/INDIA 26
  • 28. Uncaria tomentosa, Uncaria guianensis • This plant contains oxindole alkaloids tannis, quinoxic acid glycosides, flavonoids and sterols • Extract of this herb is effective in arthritis PPRC/INDIA 27
  • 29. Devdaru Cedrus deodara PPRC/INDIA 28
  • 30. Cedrus deodara • It is acute and pungent in action • This is one of the most useful drug • It is used in combination with other anti-pyretics PPRC/INDIA 29
  • 31. Ginseng liquor Panax quinquefolius PPRC/INDIA 30
  • 32. Panax quinquefolius • It contains ginsenosides which has a variety of pharmacological actions • It handles a wide variety of stresses effective in rheumatism PPRC/INDIA 31
  • 33. Garlic Allium sativum PPRC/INDIA 32
  • 34. Allium sativum • It possesses anti-inflammatory anti-arthritic, hypolipidemic, anti-coagulant, hypo-proteomic, hypo- cholesterolemic, anti-bacterial, anti-fungal, antihypersensitive and hypo-glycaemic action PPRC/INDIA 33
  • 35. Gandhaprasarini Paederia foetida PPRC/INDIA 34
  • 36. Paederia foetida • This plant exhibits disease modifying antirheumatic activity • It also helps in treating inflammatory disorders PPRC/INDIA 35
  • 37. Ginger Zingiber officinale PPRC/INDIA 36
  • 38. Zingiber officinale • Chromatographic fraction results showed that most of the fractions containing gingerols / gingerol derivatives were excellent inhibitors of LPS-induced PGE-2 production • Ginger extract when administered daily for 4 weeks caused significant reduction in PGE-2 levels in rats PPRC/INDIA 37
  • 39. Green tea Camellia sinensis PPRC/INDIA 38
  • 40. Camellia sinensis • One of the most commonly consumed beverages in the world with no side-effects • Sufficient experimental proof on the effect of Green tea’s anti-inflammatory and chondro- protective properties at molecular level PPRC/INDIA 39
  • 41. Hop tea Humulus lupulus PPRC/INDIA 40
  • 42. Humulus lupulus • It contains 32 constituents that have antiinflammatory activities • 10 out of them may act as sedative • It is popular remedy for rheumatism PPRC/INDIA 41
  • 43. Karpura Cinnamomum camphora PPRC/INDIA 42
  • 44. Cinnamomum camphora • When applied on the affected area camphor may redden the skin and produce a warm sensation • When rubbed into painful, stiff joints, ligaments and muscles, it provides soothing “camphor-ice” relief PPRC/INDIA 43
  • 45. Pepper Piper nigrum PPRC/INDIA 44
  • 46. Piper nigrum • As an external application, it dilates the superficial vessels and acts as a counter-irritant • It is used as an analgesic liniment for myalgia and rheumatic pains PPRC/INDIA 45
  • 47. Liquorice Glycyrrhiza glabra PPRC/INDIA 46
  • 48. Glycyrrhiza glabra • It acts on the body without any harmful side-effects • It has significant anti-inflammatory and anti-allergy activity • It has been historically in the treatment of inflammation, allergy and asthma PPRC/INDIA 47
  • 49. Mustard plaster Brassica alba, Brassica juncea PPRC/INDIA 48
  • 50. Brassica alba, Brassica juncea • Popular counter-irritant treatment for arthritis • Active principle – allyl-isothiocyanate • Crush the seeds in grinder, moisten the mixture with vinegar and sprinkle the flour. Spread mixture on cloth and place it on skin for > 20 mins. After removal, wash the affected area PPRC/INDIA 49
  • 51. Pineapple Ananas comosus PPRC/INDIA 50
  • 52. Ananas comosus • Active principle – “Bromelain” helps prevent inflammation • Athletic trainers recommend pineapple for athletes to prevent and treat sports injury • Bromelain help the body to get rid of immune antigen complex compounds that are implicated in arthritic conditions PPRC/INDIA 51
  • 53. Rosemary Rosmarinus officinalis PPRC/INDIA 52
  • 54. Rosmarinus officinalis • The leaves of this plant contain carnosal, oleanolic acid rosmarinic acid and ursdic acid which acts as an anti-inflammatory activity PPRC/INDIA 53
  • 55. Red pepper Capsicum sp. PPRC/INDIA 54
  • 56. Capsicum sp. • It interferes with pain perception • It contains capsaicin salicylates and others • These help to relieve arthritis PPRC/INDIA 55
  • 57. Sesame seeds Sesamum indicum PPRC/INDIA 56
  • 58. Sesamum indicum • Chinese folk medicine to eat seeds • ½ ounce of the seeds contain 4 gm of essential fatty acids, 175 mg of calcium, 64 mg of magnesium, 0.73 mg of copper • Increased copper intake may be important during arthritis attacks • A rind ½ ounce of seeds & sprinkle on food PPRC/INDIA 57
  • 59. Stinging nettle Urtica dioica PPRC/INDIA 58
  • 60. Urtica dioica • Official remedy for rheumatism in Germany • Most important herb to consider for treating early onset arthritis • Contains anti-inflammatory component similar to that of steroid drugs • Dose: 1 tablespoon juice thrice a day, freeze the juice if needed PPRC/INDIA 59
  • 61. Thunder god vine Tripterygium wilfordii Hook f. PPRC/INDIA 60
  • 62. Tripterygium wilfordii Hook f. • It is a perennial vine-like plant that grows in Southern China and Taiwan • Root extract is for treatment of various autoimmune and inflammatory diseases including RA PPRC/INDIA 61
  • 63. Turmeric Curcuma longa PPRC/INDIA 62
  • 64. Curcuma longa • Curcumin, the yellow pigment of Turmeric has significant anti-inflammatory action • Curcumin – effective as cortisone in inflammation • Dosage: 400-600 mg thrice a day • Non-toxic dietary pigment quite useful in arthritis • It is effective in liver infections PPRC/INDIA 63
  • 65. Wild cucumber bark PPRC/INDIA 64
  • 66. Wild cucumber bark • Best plant for treating rheumatism and arthritis • It is to be taken in drinking alcohol or tea PPRC/INDIA 65
  • 67. Wild yam Dioscorea villosa PPRC/INDIA 66
  • 68. Dioscorea villosa • Contains “Diosgenin” a steroid constituent with anti-inflammatory properties • Wild yam tea popular folk remedy for muscular rheumatism • Dosage: 1 ounce of wild yam root + 1 ginger root = fill jar with boiling water – mixture at room temp. Drink 2 – 3 cups / day PPRC/INDIA 67
  • 69. Willow Salix spp. PPRC/INDIA 68
  • 70. Salix spp. • Active principle: “Salicin” • Pain relieving and anti-inflammatory properties PPRC/INDIA 69
  • 71. Wintergreen Gaultheria procumbens PPRC/INDIA 70
  • 72. Gaultheria procumbens • Chief active principle: Methylsalicylate • Dried herb is used PPRC/INDIA 71
  • 73. Yucca Yucca filamentosa PPRC/INDIA 72
  • 74. Yucca filamentosa • To reduce arthritic pain • Saponin extract of Yucca showed positive therapeutic effect • It decreases bacterial endotoxin absorption thus reducing inhibition of cartilage synthesis PPRC/INDIA 73
  • 75. Thank you !!