Forthcoming plants
for
UTI treatment
(UTI – II)
Presented by
Dr. Sudhakar Kokate
Director PPRC, India
Plant categories of UTI treatment
 Botanical diuretics
 Urinary anti-septic and anti-adhesion herbs
 Botanicals with an...
My Attitude
Researchers from different labs globally need to
work closely together, discuss problems frequently
and analyz...
Data by WHO
% Use of herbal medicines
 Africa …. 80
 China …. 30 – 50
 Europe N. America …. > 50
 Germany …. 90
 Indi...
I.
Phyto Diuretics
PPRC/INDIA 04
 Solidago virgaurea L. : European goldenrod
 Solidago canadensis : Canadian goldenrod
 S. gigantea Aiton : Early golden...
 These contain saponins and tannins (Weiss 1985)
 Multiple compounds contribute to actions
(Okpanyi et. al. 1989)
 S. g...
Levisticum officinale
PPRC/INDIA 07
Levisticum officinale
 Also called Lovage root
 Family: Apiaceae
 Good diuretic (Weiss 1985)
 Major active principle: ...
Petroselinum crispus
PPRC/INDIA 09
Petroselinum crispus
 Also called Parsley
 The root / fruit is used as a Diuretic
 Folk remedy since the ancient times ...
Urtica dioica
PPRC/INDIA 11
Urtica dioica
 Also called Stinging nettle
 Parts – Leaves, Seeds
 Used as – Mild diuretic, support for urinary tract
f...
Ononis spinosa
PPRC/INDIA 13
Ononis spinosa
 Also called Spiny restharrow
 Chemicals: Phenol, Lectin, Triterpenoid, Volatile
oils – Trans anethole, C...
Equisetum arvense
PPRC/INDIA 15
Equisetum arvense
 Also called Horsetail
 Active principle: Silicic acid, Silicates
 Astringent effect on the genito-ur...
Forthcoming
Diuretic plants
PPRC/INDIA 17
 Apium graveolens: (celery) fruits
 Taraxacum officinale (Dandelion) leaves
 Parietaria judaica (Pellitory-of-the-wall)...
Apium graveolens
PPRC/INDIA 19
Taraxacum officinale
PPRC/INDIA 20
Parietaria judaica
PPRC/INDIA 21
Galium aparine
PPRC/INDIA 22
Chimaphila umbellata
PPRC/INDIA 23
Asarum europaeum
PPRC/INDIA 24
Carlina vulgaris
PPRC/INDIA 25
 Rosmarinus officinalis (Rosemary)
 Centaurium erythraea
 Spergularia purpurea
 Ananas comosus
 Carica papaya
 Cyper...
Rosmarinus officinalis
PPRC/INDIA 27
Centaurium erythraea
PPRC/INDIA 28
Spergularia purpurea
PPRC/INDIA 29
Ananas comosus
PPRC/INDIA 30
Carica papaya
PPRC/INDIA 31
Cyperus rotundus
PPRC/INDIA 32
References
 Weiss, 1985
 Halouri et. al. 2000
 Jounad et. al. 2001
 Sripanidkulchai et. al. 2001
PPRC/INDIA 33
Urinary antiseptic
&
anti-adhesion plants
PPRC/INDIA 34
Arctostaphylos uva-ursi
PPRC/INDIA 35
Arctostaphylos uva-ursi
 Also called Uva-ursi
 Active principle: Glycoside arbutoside – Arbutin
 Used for lower urinary...
Juniperus spp. fruit
PPRC/INDIA 37
Juniperus spp. fruit
 Useful in digestive disorders, kidney and bladder
problems
 Volatile oil contains > 100 compounds ...
Juniperus spp. fruit
 Additionally terpinen-4-ol acts as diuretic
 Excessive doses of Juniper on animals show
kidney irr...
Echinacea spp.
PPRC/INDIA 40
Echinacea spp.
 E. purpurea – immunostimulating property in
UTI (Kligler 2003)
 Three sp. Effective – E. purpurea
E. ang...
Hydrastis canadensis
PPRC/INDIA 42
Hydrastis canadensis
 Also known as Goldenseal
 Active principle in roots: Hydrastine, Berberine
 Berberine: no side ef...
Hydrastis canadensis
 Protective effect against several micro-organisms
including:
E. coli
Streptococcal bacteria
Chla...
Agathosma betulina
PPRC/INDIA 45
Agathosma betulina
 Also known as Buchu
 Used against UTI since the ancient times
 Native to South Africa
 Effective i...
Agathosma betulina
 In-vitro experiments show that flavonoids exhibit
anti-inflammatory effects
 Today, a tincture is us...
Zea mays
PPRC/INDIA 48
Zea mays
 Also known as Cornsilk
 Chemicals: saponins, tannins, alkaloid, hordenine,
sterols, stigmasterol, allantoin, p...
Thank You!!
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UTI - II

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This presentation is a continuation to Urinary tract infections - Part I shared earlier. UTI - II discusses various forthcoming plants for UTI treatment.

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UTI - II

  1. 1. Forthcoming plants for UTI treatment (UTI – II) Presented by Dr. Sudhakar Kokate Director PPRC, India
  2. 2. Plant categories of UTI treatment  Botanical diuretics  Urinary anti-septic and anti-adhesion herbs  Botanicals with anti-nephrotoxic activity  Plants to relieve from benign prostatic hyperplast (BPH)  Phyto-derivatives against Prostate cancer PPRC/INDIA 01
  3. 3. My Attitude Researchers from different labs globally need to work closely together, discuss problems frequently and analyze the results instantly. Herbal medicine research - 1. should be organized 2. consistent team work is absolutely vital. PPRC/INDIA 02
  4. 4. Data by WHO % Use of herbal medicines  Africa …. 80  China …. 30 – 50  Europe N. America …. > 50  Germany …. 90  India …. 40 – 70  Global market for herbal medicines …. > $ 60 bn / yr ….. And growing faster PPRC/INDIA 03
  5. 5. I. Phyto Diuretics PPRC/INDIA 04
  6. 6.  Solidago virgaurea L. : European goldenrod  Solidago canadensis : Canadian goldenrod  S. gigantea Aiton : Early goldenrod PPRC/INDIA 05
  7. 7.  These contain saponins and tannins (Weiss 1985)  Multiple compounds contribute to actions (Okpanyi et. al. 1989)  S. gigantea 60% ethanol extract on animal study (Leuschher 1995)  S. virgaurea extracts practised to prevent formation of kidney stones and to help in removing urinary gravel (Blumenthal et. al. 1998) PPRC/INDIA 06
  8. 8. Levisticum officinale PPRC/INDIA 07
  9. 9. Levisticum officinale  Also called Lovage root  Family: Apiaceae  Good diuretic (Weiss 1985)  Major active principle: Terpenoids, Iso-valeric acid, Angelic acid, Coumarins  Approved by the German Commission E for use in lower UTI and urinary gravel. (Blumenthal et. al. 1998) PPRC/INDIA 08
  10. 10. Petroselinum crispus PPRC/INDIA 09
  11. 11. Petroselinum crispus  Also called Parsley  The root / fruit is used as a Diuretic  Folk remedy since the ancient times (Yarnell 2002)  Active principles: Terpenoids, Apicol, Flavanoids, Apigenin  This herb also shows carminative and calcium channel – blocking activity in vitro (Neuhaus – Charlisle et. al. 1993) PPRC/INDIA 10
  12. 12. Urtica dioica PPRC/INDIA 11
  13. 13. Urtica dioica  Also called Stinging nettle  Parts – Leaves, Seeds  Used as – Mild diuretic, support for urinary tract functions, internal anti-inflammatory and roots as benign prostatic hyperplasia  Aqueous extract have diuretics and natriuretic effects (Tahri et. al. 2000) PPRC/INDIA 12
  14. 14. Ononis spinosa PPRC/INDIA 13
  15. 15. Ononis spinosa  Also called Spiny restharrow  Chemicals: Phenol, Lectin, Triterpenoid, Volatile oils – Trans anethole, Camphor, Menthol, Estragole, Borneol  Family: Fabaceae  Roots: Diuretic (Weiss 1985) PPRC/INDIA 14
  16. 16. Equisetum arvense PPRC/INDIA 15
  17. 17. Equisetum arvense  Also called Horsetail  Active principle: Silicic acid, Silicates  Astringent effect on the genito-urinary system (Steenkamp 2003) PPRC/INDIA 16
  18. 18. Forthcoming Diuretic plants PPRC/INDIA 17
  19. 19.  Apium graveolens: (celery) fruits  Taraxacum officinale (Dandelion) leaves  Parietaria judaica (Pellitory-of-the-wall)  Galium aparine (Cleavers)  Chimaphila umbellata (Pipsissewa)  Asarum europaeum (Asarabacca)  Carlina vulgaris (Caroline thistle) PPRC/INDIA 18
  20. 20. Apium graveolens PPRC/INDIA 19
  21. 21. Taraxacum officinale PPRC/INDIA 20
  22. 22. Parietaria judaica PPRC/INDIA 21
  23. 23. Galium aparine PPRC/INDIA 22
  24. 24. Chimaphila umbellata PPRC/INDIA 23
  25. 25. Asarum europaeum PPRC/INDIA 24
  26. 26. Carlina vulgaris PPRC/INDIA 25
  27. 27.  Rosmarinus officinalis (Rosemary)  Centaurium erythraea  Spergularia purpurea  Ananas comosus  Carica papaya  Cyperus rotundus PPRC/INDIA 26
  28. 28. Rosmarinus officinalis PPRC/INDIA 27
  29. 29. Centaurium erythraea PPRC/INDIA 28
  30. 30. Spergularia purpurea PPRC/INDIA 29
  31. 31. Ananas comosus PPRC/INDIA 30
  32. 32. Carica papaya PPRC/INDIA 31
  33. 33. Cyperus rotundus PPRC/INDIA 32
  34. 34. References  Weiss, 1985  Halouri et. al. 2000  Jounad et. al. 2001  Sripanidkulchai et. al. 2001 PPRC/INDIA 33
  35. 35. Urinary antiseptic & anti-adhesion plants PPRC/INDIA 34
  36. 36. Arctostaphylos uva-ursi PPRC/INDIA 35
  37. 37. Arctostaphylos uva-ursi  Also called Uva-ursi  Active principle: Glycoside arbutoside – Arbutin  Used for lower urinary tract infections by Commission E. 1998 (Blumenthal et. al.)  >7 pH …. Urine environment Arbutin converts hydroquinone (caution – carcinogenic) which kills bacteria (Yarnell 2002) PPRC/INDIA 36
  38. 38. Juniperus spp. fruit PPRC/INDIA 37
  39. 39. Juniperus spp. fruit  Useful in digestive disorders, kidney and bladder problems  Volatile oil contains > 100 compounds i.e. alpha and beta pinene, myrecene, limonene, sabinene and alcohol, terpinene-4-ol (Clark et. al. 1990)  Animal studies shows that extracts increase urinary volume PPRC/INDIA 38
  40. 40. Juniperus spp. fruit  Additionally terpinen-4-ol acts as diuretic  Excessive doses of Juniper on animals show kidney irritation (Schilcher and Leuschner 1997) PPRC/INDIA 39
  41. 41. Echinacea spp. PPRC/INDIA 40
  42. 42. Echinacea spp.  E. purpurea – immunostimulating property in UTI (Kligler 2003)  Three sp. Effective – E. purpurea E. angustifolia E. pallida  Purple coneflower is native to North America PPRC/INDIA 41
  43. 43. Hydrastis canadensis PPRC/INDIA 42
  44. 44. Hydrastis canadensis  Also known as Goldenseal  Active principle in roots: Hydrastine, Berberine  Berberine: no side effects, compared with antibiotics, it blocks adhesion of bacteria to epithelial cells (Subbaiah and Amin 1967, Amin et. al. 1969)  Anti-microbial activities against bacteria, fungi and protozoa PPRC/INDIA 43
  45. 45. Hydrastis canadensis  Protective effect against several micro-organisms including: E. coli Streptococcal bacteria Chlamydia and Proteus sp. Salmonella typi Entamoeba histolytica (Lahiri & Dutta 1967, Mahajan et. al. 1982, Sun et. al. 1988 b) PPRC/INDIA 44
  46. 46. Agathosma betulina PPRC/INDIA 45
  47. 47. Agathosma betulina  Also known as Buchu  Used against UTI since the ancient times  Native to South Africa  Effective in treating cases of cystitis, nephritis, catarrh of the bladder, urethritis  Active principle: Monoterpene disophenol ‘buchu’ PPRC/INDIA 46
  48. 48. Agathosma betulina  In-vitro experiments show that flavonoids exhibit anti-inflammatory effects  Today, a tincture is used in treatment of genital and UTI such as kidney stones, prostatitis PPRC/INDIA 47
  49. 49. Zea mays PPRC/INDIA 48
  50. 50. Zea mays  Also known as Cornsilk  Chemicals: saponins, tannins, alkaloid, hordenine, sterols, stigmasterol, allantoin, polyphenols, Vitamin K, B and C  It soothes and relaxes the lining of ureter, bladder and urethra  Relieving irritation and improving urine excretion (Steenkamp 2003) PPRC/INDIA 49
  51. 51. Thank You!! “BE WITH US”

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