• Share
  • Email
  • Embed
  • Like
  • Save
  • Private Content
Pharmacology
 

Pharmacology

on

  • 1,087 views

 

Statistics

Views

Total Views
1,087
Views on SlideShare
983
Embed Views
104

Actions

Likes
1
Downloads
0
Comments
0

1 Embed 104

http://www.scoop.it 104

Accessibility

Upload Details

Uploaded via as Microsoft PowerPoint

Usage Rights

© All Rights Reserved

Report content

Flagged as inappropriate Flag as inappropriate
Flag as inappropriate

Select your reason for flagging this presentation as inappropriate.

Cancel
  • Full Name Full Name Comment goes here.
    Are you sure you want to
    Your message goes here
    Processing…
Post Comment
Edit your comment

    Pharmacology Pharmacology Presentation Transcript

    • PHARMACOGENOMICS BY, Ajoy Aloysius & Nidhish Thampi
    • PHARMACOGENOMICS (PHARMACOLGY+GENOMICS)
      • Pharmacogenomics is the study of how individual’s genetic inheritance affects the body’s response to drugs.
      • It is an application of genomic tool in traditional pharmacology.
      • It will give predictive medicine & personalised medication.
      • It is a promissing field in futuristic medication.
    • HISTORY
      • First observation of genetic variation in drug response dates back to 1950s, involving the muscle relaxant suxamethonium chloride and drug metabolised by N-acetyl transferase .
      • About 106,000 deaths &2.2 million serious events due to the adverse drug reactions (ADRs).
      • ADRs are responsible for 5-7% of hospital admissions in Europe and US.
      • “ ONE SIZE DOES NOT FIT ALL”
    • A NEW APPROACH
    • PHARMACOGENOMIC TECHNOLOGY
      • Genotyping(DNA sequencing,SNPs)
      • Protein sequencing
      • Functional phenotyping
      • RFLP,DNA micro arrays,SSCP
      • Mass spectrometry
    • Is Pharmacogenomics in use today?
      • The cytochrome P450(CYP) :family of liver enzyme responsible for breaking 30 different drugs.
      • Today clinical researchers use genetic test for variation of CYP450.
      • Thiopurine methyltransferase (TMPT): important role in chemotherapy treatment of leukemia (Breaking of Thiopurines )
      • Doctors can use genetic test to monitor TMPT activity to determine Thiopurine level.
    • APPLICATIONS OF PHARMACOGENOMICS
      • More powerful medicines.
      • Better, safer drugs the first time.
      • More accurate methods of determining appropriate drug dosages.
      • Advanced screening for diseases.
      • Improvements in the drug discovery and approval process.
      • Better vaccines.
      • Decrease in overall cost of health care.
    •  
    •  
    • BARRIERS TO PHARMACOGENOMIC PROGRESS
      • Complexity of finding gene variations that affect drug response.
      • Limited drug alternatives.
      • Disincentives for drug companies to make multiple pharmacogenomic products.
      • Educating health care providers.
    • PHARMACOGENOMICS IN FUTURE (COMPUTERISED MEDICATION)
      • Imagine a computerised machine replacing the doctors role in medication.
      • The patient is provided with a genotype card containing his/her genotypic data.
      • The patient inserts the card in to the machine and later on the machine scans and identifies the disease which is compared with his/her genotype.
      • There by prescribing the apt and safest drug and its dosage.
    • THANK YOU