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NAMRATA
  KAKADE
M.Sc. G.E.-
    10006
 Definition
 History
 Issues
 Facts
 Meaning Of CLONE
 Benefits
 Process
 Advantages & Disadvantages
 Effects
 Applications
 Future
 Conclusion
   Cloning is a
    creation of an
    organism that is an
    exact copy of
    another. This
    means that every
    single bit of DNA is
    the same between
    the two.!!
   Everybody knows about
    Dolly the cloned
    sheep, but few people
    know all the details about
    cloning, including the fact
    that scientists have been
    working on it for over 100
    years.
A.   Legal aspects

 Animal testing – breeding for
  unhealthy traits
 Violation of constitutional rights
 Inclusion of animal protection in the
  Constitution
B. Ethical aspects

   Associated with ethical considerations of fellow-creature
    status and an ethical judgement on animal cloning.

   Different positions in the social debate and assessment of
    animal cloning can be traced back to some extent to
    different fundamental values.

   seen as having a new quality compared with conventional
    animal breeding or with other new techniques in animal
    breeding as well.

   the potential risks and hazards – ecological (reducing
    genetic diversity) and social (industrial mass
    production, concentration of capital, new dependencies).
   Scientists have successfully cloned a
    calico cat named rainbow. The scientists
    named the cat cc which stands for carbon
    copy.
   Cloned animals age faster than normal
    animals!!!
   The first cloned animal was a tadpole!!!
   A calf was cloned from a side of beef!!!
   Cloning can later lead to genetic diseases
    in cloned animals. Cloned organisms are
    less healthy than there parent organism.
   "Clones are genetic copies of an animal
    and They're similar to identical twins, but
    born at different times.“

    Cloning can be thought of as an extension
    of the assisted reproductive technologies
    that livestock breeders have been using for
    centuries, such as artificial
    insemination, and more recently, embryo
    transfer and in vitro fertilization.
 GE animals hold great promise for
  human and animal health, the
  environment, and agriculture.
 Health protection of animals
 New source of medicines
 Transplantation
 Less environmental impact
 Healthier food
   Somatic cell collected      Egg cell collected from
    from that is to be           female of the same
    cloned i.e. Genetic          species i.e. Egg Donor
    Donor.
Advantages of Animal                            Disadvantages of Animal
Cloning                                         Cloning

   There will be an endless supply of             Although the cloned animal will be
    animals to clone, and we will never run         identical. It will only possess about half
    out of food from animals, because we            the life span of the normal animal which
    have been able to clone based on                has been cloned. An example is from
    previous efforts, the most famous of            the famous ‘Dolly’ previous mentioned
    these was the first ever cloning of an          which only lived for 6 years, whereas
    animal, Dolly the lamb which was a              normal sheep can live up to about 10
    successful cloning where Dolly was a            years of age, so a great decrease in
    healthy lamb.                                   age.


   The animal in which we intend to clone         Reasons for cloning aren’t exactly for
    will result perfectly the same as the           keeping resources, such as food for the
    animal which has been cloned in every           future, but in fact we are basically taking
    way, identical in all senses of the word.       embryos from the animal for research
    The eyes, the nose, the ears, the               and by doing this leaving the animal
    face, everything! Dolly was a perfect           useless. This is similar to humans being
    example of this through how she came            cloned, where there human embryos are
    out exactly the same. But this sheep is         taken away from them for research
    not the only animal which cloning can           because they believe that it isn’t really a
    work effectively on, there are many             person. However, if it is alive and has
    animals which have also been                    every trait that a humans has, then how
    successfully cloned such as horses and          can it be called useless to us?
    bulls, just not as famous as Dolly.
Advantages                          Disadvantages

   Through animal cloning, we           Even if we can clone animals
    can go into further research          and make them perfectly the
    into how complicated and              same, is this what God
    intricate our world that God          would’ve wanted? For us to
    created really is, and could          have the power to clone living
    discover information that             organisms such as
    we’ve never seen before.              animals, and one day even
                                          human beings?
   One of the greatest
    breakthroughs of all                 Many believe cloning is quite
    time, cloning has been                inhumane, especially that of
    discovered, something which           religious and some
    could be revolutionary if we          governmental parties which
    use it to our advantage               don’t want to move forward
    through continuing on with our        with this research. They think
    research and studies into             life is just too precious to take
    it, with discoveries that could       away, even if it is a clone in
    change our lives forever.             which we are testing.
   The offspring of cloned       People can get an animal
    animals are often born         that looks the same as
    deformed                       the pet they had
                                  Scientists can clone
   It is against religious        organs and help people
    beliefs                        live longer

   Pets that are cloned          Scientists can also clone
    often do not come out          body parts such as ears
    having the same                to surgically attach to a
    personality and can look       person, Cloned animals
    different                      are safe to eat
   Expensive and highly inefficient.

   More than 90% of cloning attempts fail to produce a viable
    offspring.

   In addition to low success rates, cloned animals tend to
    have more compromised immune function and higher rates
    of infection, tumour growth, and other disorders.

   Many cloned animals have not lived long enough to
    generate good data about how clones age.
   Appearing healthy at a young age unfortunately is not a
    good indicator of long term survival.

   Clones have been known to die mysteriously. For
    example, Australia's first cloned sheep appeared healthy
    and energetic on the day she died, and the results of
    her autopsy failed to determine a cause of death.
1.   Biomedical research
    Animals as drug producers
    Animal models
    Breeding androgenic body tissue
    Xenotransplantation


2. Livestock breeding and agriculture
    Transgenic clones
    Changes to agricultural structures
3. According to FDA Meat
   and milk from cow, pig,
   and goat clones, and
   the offspring of any
   clones, are as safe as
   food we eat every day.

4. The main use of
   clones is to produce
   breeding stock, not
   food.

    Due to the inefficiency of animal
    cloning and the lack of understanding
    about reproductive cloning, many
    scientists and physicians strongly
    believe that it would be unethical to
    attempt to clone humans.

   Not only do most attempts to clone
    mammals fail, about 30% of clones
    born alive are affected by "large
    offspring syndrome" and other
    debilitating conditions. Several
    cloned animals have died
    prematurely from infections and other
    complications.
   The same problems would be expected in human
    cloning. In addition, scientists do not know how cloning
    could impact mental development. While factors such as
    intellect and mood may not be as important for a cow or
    a mouse, they are crucial for the development of healthy
    humans. With so many unknowns concerning
    reproductive cloning, the attempt to clone humans at
    this time is considered potentially dangerous and
    ethically irresponsible.
Scientists have accelerated more into the world of
animal cloning. Since Dolly, the first cloned
mammal, was created, scientists have cloned many
more of the mammalian species, such as
cats, horses, pigs, cows, and a big supply of
rodents. But where is it going?

For a few hundred years, scientists have tried to
protect endangered species. Why not just clone
them? Want to bring back the dinosaurs? Clone
them. The process of copying an animal could
indeed do miracles.


Scientists plan on rooting out the diseases of the
Donor animal by using DNA transfer
techniques. Using these techniques they also plan
on making better meat and food carried by livestock
and other animals such as pigs and sheep. The fur
will also be enhanced
   The same technique will be used to purify the proteins in medicines and
    therefore help ones struggling with a mortal disease. Scientists will do
    this by biologically engineering the proteins then export them globally.

   Cloning is also very dangerous. Already political fights are started
    because of the biological copying. The majority of the masses are
    against the process, but scientists, Cloners, and most people who can
    afford the money to clone their pets think it's a wonderful enhancement in
    biological science.

   The risks of cloning are incredible. What if the cloning tools were
    contaminated when they were used to fix the proteins of medicines? A
    serious disease could start and the world would lose a huge chunk of its
    population.
   In applied research, cloning using nucleus transfer opens up
    new approaches to creating transgenic animals. Some proteins
    with therapeutic effect can be cheaply produced in this way.


   In agriculture the (practicable) production of clones of breeding
    stock promises to improve animal performance and quality
    while simultaneously reducing production costs. It is likely that
    cloning techniques will add further weight to existing trends in
    optimising the performance potential of livestock, i.e. high-
    performance animals. With regard to the questions of genetic
    improvement and diversity in animal breeding, selection for
    specific performance characteristics can have the goal of
    standardising (breeding) livestock with the help of cloning, and
    hence inevitably standardising livestock generally
 www.fda.org
 www.biotecnika.org
 www.genome.gov
 www.library.thinkquest.org
 www.metrolic.com
 www.bioethics.georgetown.org
 www.nms.com
Animal cloning

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Animal cloning

  • 1. NAMRATA KAKADE M.Sc. G.E.- 10006
  • 2.  Definition  History  Issues  Facts  Meaning Of CLONE  Benefits  Process  Advantages & Disadvantages  Effects  Applications  Future  Conclusion
  • 3. Cloning is a creation of an organism that is an exact copy of another. This means that every single bit of DNA is the same between the two.!!
  • 4. Everybody knows about Dolly the cloned sheep, but few people know all the details about cloning, including the fact that scientists have been working on it for over 100 years.
  • 5. A. Legal aspects  Animal testing – breeding for unhealthy traits  Violation of constitutional rights  Inclusion of animal protection in the Constitution
  • 6. B. Ethical aspects  Associated with ethical considerations of fellow-creature status and an ethical judgement on animal cloning.  Different positions in the social debate and assessment of animal cloning can be traced back to some extent to different fundamental values.  seen as having a new quality compared with conventional animal breeding or with other new techniques in animal breeding as well.  the potential risks and hazards – ecological (reducing genetic diversity) and social (industrial mass production, concentration of capital, new dependencies).
  • 7. Scientists have successfully cloned a calico cat named rainbow. The scientists named the cat cc which stands for carbon copy.  Cloned animals age faster than normal animals!!!  The first cloned animal was a tadpole!!!  A calf was cloned from a side of beef!!!  Cloning can later lead to genetic diseases in cloned animals. Cloned organisms are less healthy than there parent organism.
  • 8. "Clones are genetic copies of an animal and They're similar to identical twins, but born at different times.“  Cloning can be thought of as an extension of the assisted reproductive technologies that livestock breeders have been using for centuries, such as artificial insemination, and more recently, embryo transfer and in vitro fertilization.
  • 9.  GE animals hold great promise for human and animal health, the environment, and agriculture.  Health protection of animals  New source of medicines  Transplantation  Less environmental impact  Healthier food
  • 10.
  • 11. Somatic cell collected  Egg cell collected from from that is to be female of the same cloned i.e. Genetic species i.e. Egg Donor Donor.
  • 12.
  • 13. Advantages of Animal Disadvantages of Animal Cloning Cloning  There will be an endless supply of  Although the cloned animal will be animals to clone, and we will never run identical. It will only possess about half out of food from animals, because we the life span of the normal animal which have been able to clone based on has been cloned. An example is from previous efforts, the most famous of the famous ‘Dolly’ previous mentioned these was the first ever cloning of an which only lived for 6 years, whereas animal, Dolly the lamb which was a normal sheep can live up to about 10 successful cloning where Dolly was a years of age, so a great decrease in healthy lamb. age.  The animal in which we intend to clone  Reasons for cloning aren’t exactly for will result perfectly the same as the keeping resources, such as food for the animal which has been cloned in every future, but in fact we are basically taking way, identical in all senses of the word. embryos from the animal for research The eyes, the nose, the ears, the and by doing this leaving the animal face, everything! Dolly was a perfect useless. This is similar to humans being example of this through how she came cloned, where there human embryos are out exactly the same. But this sheep is taken away from them for research not the only animal which cloning can because they believe that it isn’t really a work effectively on, there are many person. However, if it is alive and has animals which have also been every trait that a humans has, then how successfully cloned such as horses and can it be called useless to us? bulls, just not as famous as Dolly.
  • 14. Advantages Disadvantages  Through animal cloning, we  Even if we can clone animals can go into further research and make them perfectly the into how complicated and same, is this what God intricate our world that God would’ve wanted? For us to created really is, and could have the power to clone living discover information that organisms such as we’ve never seen before. animals, and one day even human beings?  One of the greatest breakthroughs of all  Many believe cloning is quite time, cloning has been inhumane, especially that of discovered, something which religious and some could be revolutionary if we governmental parties which use it to our advantage don’t want to move forward through continuing on with our with this research. They think research and studies into life is just too precious to take it, with discoveries that could away, even if it is a clone in change our lives forever. which we are testing.
  • 15. The offspring of cloned  People can get an animal animals are often born that looks the same as deformed the pet they had  Scientists can clone  It is against religious organs and help people beliefs live longer  Pets that are cloned  Scientists can also clone often do not come out body parts such as ears having the same to surgically attach to a personality and can look person, Cloned animals different are safe to eat
  • 16.
  • 17. Expensive and highly inefficient.  More than 90% of cloning attempts fail to produce a viable offspring.  In addition to low success rates, cloned animals tend to have more compromised immune function and higher rates of infection, tumour growth, and other disorders.  Many cloned animals have not lived long enough to generate good data about how clones age.
  • 18. Appearing healthy at a young age unfortunately is not a good indicator of long term survival.  Clones have been known to die mysteriously. For example, Australia's first cloned sheep appeared healthy and energetic on the day she died, and the results of her autopsy failed to determine a cause of death.
  • 19. 1. Biomedical research  Animals as drug producers  Animal models  Breeding androgenic body tissue  Xenotransplantation 2. Livestock breeding and agriculture  Transgenic clones  Changes to agricultural structures
  • 20. 3. According to FDA Meat and milk from cow, pig, and goat clones, and the offspring of any clones, are as safe as food we eat every day. 4. The main use of clones is to produce breeding stock, not food.
  • 21. Due to the inefficiency of animal cloning and the lack of understanding about reproductive cloning, many scientists and physicians strongly believe that it would be unethical to attempt to clone humans.  Not only do most attempts to clone mammals fail, about 30% of clones born alive are affected by "large offspring syndrome" and other debilitating conditions. Several cloned animals have died prematurely from infections and other complications.
  • 22. The same problems would be expected in human cloning. In addition, scientists do not know how cloning could impact mental development. While factors such as intellect and mood may not be as important for a cow or a mouse, they are crucial for the development of healthy humans. With so many unknowns concerning reproductive cloning, the attempt to clone humans at this time is considered potentially dangerous and ethically irresponsible.
  • 23. Scientists have accelerated more into the world of animal cloning. Since Dolly, the first cloned mammal, was created, scientists have cloned many more of the mammalian species, such as cats, horses, pigs, cows, and a big supply of rodents. But where is it going? For a few hundred years, scientists have tried to protect endangered species. Why not just clone them? Want to bring back the dinosaurs? Clone them. The process of copying an animal could indeed do miracles. Scientists plan on rooting out the diseases of the Donor animal by using DNA transfer techniques. Using these techniques they also plan on making better meat and food carried by livestock and other animals such as pigs and sheep. The fur will also be enhanced
  • 24. The same technique will be used to purify the proteins in medicines and therefore help ones struggling with a mortal disease. Scientists will do this by biologically engineering the proteins then export them globally.  Cloning is also very dangerous. Already political fights are started because of the biological copying. The majority of the masses are against the process, but scientists, Cloners, and most people who can afford the money to clone their pets think it's a wonderful enhancement in biological science.  The risks of cloning are incredible. What if the cloning tools were contaminated when they were used to fix the proteins of medicines? A serious disease could start and the world would lose a huge chunk of its population.
  • 25. In applied research, cloning using nucleus transfer opens up new approaches to creating transgenic animals. Some proteins with therapeutic effect can be cheaply produced in this way.  In agriculture the (practicable) production of clones of breeding stock promises to improve animal performance and quality while simultaneously reducing production costs. It is likely that cloning techniques will add further weight to existing trends in optimising the performance potential of livestock, i.e. high- performance animals. With regard to the questions of genetic improvement and diversity in animal breeding, selection for specific performance characteristics can have the goal of standardising (breeding) livestock with the help of cloning, and hence inevitably standardising livestock generally
  • 26.  www.fda.org  www.biotecnika.org  www.genome.gov  www.library.thinkquest.org  www.metrolic.com  www.bioethics.georgetown.org  www.nms.com