The health of your skin and genetics

1. Ginny Bank
Brief Bio
Ginny Bank is the Director of Product Education and Technical Support for GeneWize
Life Sciences.
Ms. Bank has significant experience in the dietary supplement and functional food
industries and began her career as a natural products chemist with a research
company (Hauser, Inc.) which focused on developing natural product extracts and
purified plant compounds for the dietary supplement, pharmaceutical and food
industries.
She is considered an industry expert in antioxidant research and throughout her career
has been researching and developing plant-based functional ingredients for a variety
of nutritional supplement applications. Ms. Bank holds four U.S. patents pertaining to
antioxidants and their applications and is a contributing editor for Prepared Foods
/NutraSolutions Magazine. She received her bachelor’s degree in Chemistry and a
Master’s Degree in Science Education from the University of Colorado, Boulder.

2. LifeMap Me™ Skin Repair Serum Formula
An Overview
• The LifeMap Me™ Skin Repair Serum Formula is a scientifically-proven antiwrinkle firming formulation customized just for you based on your own
(genetically-determined) skin-care needs.
• The Genelink®’s Healthy Skin Aging DNA Assessment measures for variations
in 6 key skin aging genes that are very important to your skin’s overall skin
health and appearance and are based on your genetic propensity for:
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Collagen breakdown
Photo-aging
Wrinkling, skin aging and slackening
Skin’s ability to tolerate environmental pollutants
• The LifeMap Me™ Skin Repair Serum formulas are customized based on the
Genelink®’s Healthy Skin Aging DNA Assessment .
– Base formula - Foundational blend of skin care ingredients
– SNPActives™ - Contain active ingredients that specifically help treat and control
problems areas identified by the DNA skin profile.

3. The Science – Base Serum
Base Serum contains a proprietary blend of skin care
ingredients for all skin types
• Aloe - moisturizer
• Soy Protein - antioxidant, anti-inflammatory, collagen
stimulating
• Skin Health Vitamins (A, C, B5 and E)
• Cereal Grain Extracts
– Oat Extract (Hydrolyzed Glycosaminoglycans) to increase
hydration in the cell layers of the skin
– Corn Extract (source of Sodium Levulinate) to condition the
skin.
– Rice Extract (source of sodium phytate) to improve skin color
– Barley Extract as a good source of antioxidants

4. The Science – Base Serum
• Plants and Plant Extracts
– Balm Mint (Melissa officinalis) Extract - soothing tonic for skin.
– Konjac Mannan fiber– Moisturizing and water-binding activity
– Green Tea Extract
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Antioxidant
Anti-inflammatory
Reduce UV damage
Prevent collagen breakdown
Milk Thistle Extract - protect against UV-damage
Cabbage Leaf Extract - reduce swelling
Cat’s Claw Extract - antioxidant and anti-inflammatory
Super Fruit Extracts (Açai, Goji Berry, Mangosteen,
pomegranate) - anti-aging/antioxidant
– Tomato Extract (Lycopene) - protects against UV-damage

5. SNPActives™
ADDED
SUPPORT
MAXIMUM SUPPORT
Optimal Genetic
Function
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Heterozygous Disadvantaged :
Homozygous Disadvantaged:
Homozygous Advantaged :
One chromosome carries the SNP
Both chromosomes carries the SNP
Neither chromosome carries the SNP
• Amount of SNPActive™ in each individual formula is dependent upon results
of the Genelink®’s Healthy Skin Aging DNA Assessment .
– Heterozygous disadvantaged receive Added support from SNPActive™
– Homozygous disadvantaged receive Maximum support from SNPActive™
• Individual SNPActive™ formulations were designed to address each
(enzymatic) genetic marker identified in the Genelink®’s Healthy Skin Aging
DNA Assessment.
• Each SNPActive™ was tested in vitro and demonstrated enhancement or
diminishment of the enzymatic activity pertinent to the appropriate genetics
marker

6. The Science – EPHX SNPActive™
• Human microsomal Epoxide Hydrolase (EPHX) is a phase-I xenobiotic
metabolizing enzyme that detoxifies potentially toxic epoxides
• Xenobiotics are foreign substances (e.g. pollutants, pesticides) which
can cause skin irritation
• In vitro test showed upregulation of EPHX enzyme
Test Material
SNP-Related Enzyme
Activity (Compared to
Untreated Control)
Analysis Method
EPHX SNPActive™
Microsomal epoxide
hydrolase
Enhanced 
Flouresence
EPHX SNPActive™ provides ingredients to:
 Protect the skin from toxins
 Promote skin cells growth after damage by toxins
 Prevent irritation causes by environmental toxin exposure

7. The Science - EPHX SNPActive™
• N-Acetylcysteine
– Neutralizes toxins
– Increases glutathione peroxidase activity
– Protects against UV radiation
• Fennel Extract
– antioxidant compounds to protect skin from the detrimental
effects of the environment
– Anti-inflammatory
• Trimethylglycine
– Anti-irritant
– Increase skin moisturization, elasticity and hydration
• Folic Acid
– Contributes to healthy skin cell division
– Replenishes skin cells for younger, firmer looking skin

8. The Science – GPX1 SNPActive™
•
GPX1 is the most abundant antioxidant enzyme in the Glutathione Peroxidase family with
specific activity against hydrogen peroxide. Hydrogen peroxide is produced:
– During exposure to sunlight
– Stimulation of acne bacteria
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•
Hydrogen peroxide plays a major role in both chronological and photo-aging of skin because
it is the most common source of oxidative stress
SNP on GPX1 gene may show a reduced function in quenching hydrogen peroxide in skin
cells.
GPX1 enzyme contains selenium in its protein structure and therefore how much GPX1 a
person produces is dependent on their selenium levels
In vitro test showed upregulation of GPX1 enzyme
Test Material
SNP-Related Enzyme
Activity (Compared to
Untreated Control)
Analysis Method
GPX1 SNPActive™
Glutathione
peroxidase
Enhanced 
Colormetric
GPX1 SNPActive™ provides
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Ingredients that protect the body against hydrogen peroxide damage
Extra selenium
Ingredients that increase glutathione peroxidase activity
Ingredients to help heal acne

9. The Science – GPX1 SNPActive™
• N-Acetylcysteine – increases glutathione peroxidase activity
and protects against UV radiation
• Amino acids Glutamine & Glycine –
– antioxidants
– wound-healing (acne) activity
• Plant Extracts (grape, aloe leaf and fennel) –
– anti-inflammatory
– antioxidant activity against hydrogen peroxide
• Saccharomyces/Selenium Ferment
– Ingredient created by the fermentation of the Saccharomyces yeast with
the mineral selenium.
– This anti-aging ingredient that protects against hydrogen peroxide
damage and boosts SPF
– Provides added selenium to skin

10. The Science – MMP-1 SNPActive™
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MMP-1 (collagenase) is an enzyme that degrades collagen
Collagen is the main protein of skin
– Collagen is constantly synthesized and broken down in an ongoing cycle to form
new tissue.
– Collagen degradation is the major factor in aging of skin
• Wrinkles
• Loss of elasticity
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MMP-1 enzyme production is increased with age and exposure to sunlight
SNPs in the MMP-1 gene causes increased rates of collagenase production
leading to more collagen breakdown
In vitro test showed downregulation of MMP-1 enzyme
Test Material
MMP1 SNPActive™
SNP-Related Enzyme
Matrix
metalloproteinase
Activity (Compared to
Untreated Control)
Analysis Method
Diminished 
ELISA
MMP-1 SNPActive™ provides ingredients to:
 Strengthen collagen
 Protect collagen against free radical damage

11. The Science – MMP-1 SNPActive™
• Saccharomyces cerevisiae (yeast)
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Improves skin moisture
Improves skin microrelief
Increases skin microcirculation
Antioxidant to protect against free radical damage to
collagen
• Polyglucan – helps preserve, strengthen and protect
collagen
• Panthenol – Pro-Vitamin B5
– Helps diminish wrinkles by infusing moisture deeper into
skin layers
– Anti-inflammatory
– Stimulates cell growth
Normal Skin microrelief
Oily Skin microrelief
Dry Skin microrelief

12. The Science – SOD2 SNPActive™
•
SOD2 gene encodes for Superoxide Dismutase (SOD), is an antioxidant enzyme which helps
neutralize superoxide radicals in the skin cells, produced by:
– UV exposure
– Acne bacteria
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SNPs on the SOD2 gene can lead to a damaging build-up of the superoxide radicals.
The skin's enzymatic antioxidant defense - copper-zinc superoxide dismutase (CuZnSOD),
manganese SOD (MnSOD) - have are modulated by UVB and UVA irradiation
In photo-aged skin, a significant depletion of antioxidant enzyme expression is observed
within the stratum corneum and in the epidermis
• In vitro test showed upregulation of SOD2 enzyme
Test Material
SNP-Related Enzyme
Activity (Compared to
Untreated Control)
Analysis Method
SOD2 SNPActive™
Superoxide dismutase
Enhanced 
Colormetric
SOD2 SNPActive™ provides:
 Antioxidant ingredients with specific activity against the superoxide radical
 Superoxide dismutase

13. The Science – SOD2 SNPActive™
• Superoxide dismutase – topical treatment with SOD has
been shown to
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Counteract the reduced expression of SOD by UV light
Protect skin proteins (collagen and ellastin) from oxidation
Protects skin against inflammation caused by acne
Protect skin against photodamage
• Saccharomyces (Yeast)/Manganese ferment and Copper Ferment
– Antioxidant to quench superoxide radical
– Promote would healing
– Firms and rejuvenates the skin

14. The Science – TNF-α SNPActive™
• Tumor Necrosis Factor- alpha (TNF-α) is a chemical messenger which mobilizes
white blood cells to fight infections and other invaders.
• TNF-α has been found at elevated levels in patients with psoriasis, acne and other
inflammatory skin diseases
• Toxins and UV light are potent inducers of TNF-α release from the epithelial cells
that comprise skin
• SNPs on the TNF-α gene may result in an over-reactive inflammatory response and
a predisposition to acne and other skin conditions
• In vitro test showed downregulation of TNF-α
Test Material
SNP-Related Enzyme
Activity (Compared to
Untreated Control)
Analysis Method
TNF-α SNPActive™
Tumor necrosis alpha
Diminished 
ELISA
TNF-α SNPActive™ provides ingredients to:
 Reduce inflammation
 Reduce irritation

15. The Science – TNFα SNPActive™
• Red algae extract
– Reduces concentration of nitric oxide, which causes skin
inflammation
– Reduces skin irritation
• Clover leaf extract
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Skin regenerating activity
Antioxidant-rich
Contains isoflavones, which help prevent skin photo-damage
Helps treat psoriasis and acne

16. The Science – NQ01 SNPActive™
• The coenzyme Q10 reductase (NQO1) converts CoQ10 (ubiquinone) to its
reduced form, ubiquinol, which scavenges free radicals in the
mitochondria and lipid membranes.
• Individuals with a SNP in the NQO1 gene have reduced ability to make this
conversion from ubiquinone to ubiquinol, resulting in very low blood and
tissue levels of this key antioxidant.
• CoQ10-depleted skin tissue may be particularly more prone to the
damage by free radicals because of its constant exposure environmental
oxidants such as sunlight and pollution.
• Research has shown that CoQ10 may inhibit the production of epidermal
cell interleukin-6, which stimulates fibroblasts in the dermis and
contributes to protecting dermal fiber components from degradation,
leading to rejuvenation of wrinkled skin.
NQ01 SNPActive™ provides:
 Ubiquinol (Red and Yellow)
 Ubiquinone (Green)

17. Clinically-proven
8-week double-blind randomized (half-face) study
OVERALL IMPROVEMENT ALL PARAMETERS
•
LifeMap Me™ significantly out-performed the
placebo for all areas in both qualitative and
5
4
3
quantitative measurements
PRODUCT
2
CONTROL
•
1
0
DAY
14
28
62% reported substantial reduction in appearance
of wrinkles after 14 days of treatment
54
•
•
FINE LINES IMPROVEMENT
After 56 days the number rose to 70%
Similarly, after 14 days, 56% reported improved
skin firmness
0.5
PRODUCT
0
CONTROL
-0.5
DAY
14
28
56
•
After 8 weeks 70% indicated improved skin
firmness

18. Thank You!