In the many years that we've been providing Plone consulting services, we've done some projects where Plone was clearly not the best choice of technology for the job, and we paid the price of making the wrong decision.
In other projects, we've steered the customer to use one of the Python web application frameworks such as Django or Pyramid, and we and the customer have been pleased with the results.
In this talk, Nate Aune explores scenarios when a full-featured CMS such as Plone is the right tool for the job, and when a more lightweight web framework is preferable.
A link to audio of the presentation is here: http://2011ploneconference.sched.org/event/31d3dc2be7404f5515cd47050e144cb7
Clipping is a handy way to collect important slides you want to go back to later.