Salesforce.com is a mature, feature-rich, highly customizable, software-as-a-service CRM that has had excellent integration with Plone since 2007. The combination of Plone and Salesforce.com is a great deal for non-profits - the Salesforce Foundation will donate up to 10 enterprise licenses to 501(c)3 organizations, and any additional licenses are deeply discounted.
In this talk I will review the Plone+Salesforce integration toolkit, describe recent improvements to the toolkit, and contrast this with what other CMSes have to offer.