Introduction to GN glomerulonephritis, case-based approach Ahmed Yehia lecturer of internal medicine, Beni-Suef University
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Introduction to GN glomerulonephritis case-based approach Approach to acute kidney injury and GN diagnostics, classification and differential diagnosis. Also discussing histopathology basics Dr. Ahmed Yehia, lecturer of internal medicine, Beni-Suef University
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Introduction to GN glomerulonephritis, case-based approach Ahmed Yehia lecturer of internal medicine, Beni-Suef University
- 1. Glomerulonephritis Ahmed Yehia, MD Internal Medicine Beni-Suef
- 2. A 16-year-old female presented with severe intractable vomiting for 3 days with poor response to anti-emetics. She received IV PPI & anti-emetics in the ER. What is the next step?
- 3. Etiology of vomiting GIT Non-GIT
- 4. S. CREATININE: 4 MG/DL. ACUTE SUPPORTIVE MEASURES DONE. HOW TO PROCEED TO SEARCH FOR THE ETIOLOGY?
- 10. BP: 110/80. No signs of dehydration.
- 11. To assess for postrenal causes Normal U/S
- 12. Urine analysis (The treasure) RBCs 20 – 30/hpf Protein ++ What is the cause of hematuria?
- 15. Urine analysis (The treasure)
- 16. Urine analysis (The treasure)
- 18. ASOT: positive, 600 •She gives history of these lesions 3 weeks ago. •What is the next step?
- 20. AFTER 2 MONTHS OF FOLLOW UP, HER BP BECAME 110/80. HER CREATININE BECAME 1 MG/DL.
- 21. Glomerulonephritis •Immune mediated glomerular injury with symmetrical simultaneous involvement of both kidneys at the same time.
- 24. "focal and segmental necrotizing glomerulonephritis" "diffuse global proliferative glomerulonephritis" Focal segmental glomerulosclerosis
- 26. Histologic descriptions "proliferative ++ number of cells in the glomerulus predominantly in mesangium mesangial proliferative GN within the capillary wall Endocapillary hypercellularity in an extracapillary location sclerosing scarring necrotizing areas of cell death
- 27. "focal and segmental necrotizing glomerulonephritis" "diffuse global proliferative glomerulonephritis" Focal segmental glomerulosclerosis
- 29. MED-Learn
- 31. • A 23-year-old woman presented with hematuria. Her blood pressure was normal, and she had no rash, joint pain, or other symptoms. Urinalysis was positive for proteinuria and hematuria, and urinary sediment analysis showed dysmorphic red blood cells (RBCs) and red cell casts, leading to a diagnosis of glomerulonephritis. She had proteinuria of 1.2 g/24 hours. Laboratory tests for systemic diseases were negative. Renal biopsy study revealed stage III immunoglobulin A (IgA) nephropathy.
- 33. Extracapillary proliferation (crescents): accumulations of macrophages, fibroblasts, proliferating epithelial cells & fibrin within Bowman's space & represent rupture of the glomerular membrane, signifying severe injury to glomerular capillary wall.
Editor's Notes
- On a pathological basis, glomerular lesions can be diffuse (all glomeruli are involved) or focal(only some glomeruli are involved [typically less than 50 percent]). At the level of the individualglomerulus, a process is global if the whole glomerular tuft is involved or segmental if only aportion is involved (less than 50 percent).
- On a pathological basis, glomerular lesions can be diffuse (all glomeruli are involved) or focal(only some glomeruli are involved [typically less than 50 percent]). At the level of the individualglomerulus, a process is global if the whole glomerular tuft is involved or segmental if only aportion is involved (less than 50 percent).