1) The document discusses using transdermal carbon dioxide (CO2) delivery via a handheld device called D'Oxyva to increase microcirculation and promote wound healing. 2) It provides background on how CO2 acts as a vasodilator and how increased CO2 levels via this device can boost oxygen delivery and tissue perfusion. 3) Several case studies and observations are presented showing accelerated wound healing in patients using the D'Oxyva device to deliver transdermal CO2.