Viral Gene TherapyPresented by Alex Bunk
What It Is Viral Gene therapy is the methodic use of viruses that  normally cause illness as vectors to transfer genes th...
What It IsThere is a lack of an efficient non-toxic delivery system to provide the successful application of gene therapy ...
How It Works Viral gene therapy works by first removing the genes of a  viral vector then replacing it with genes that wi...
What It Can Cure Viral gene therapy is capable of curing a multitude of  diseases, both genetic and acquired. Diseases t...
Viral Vectors Used The two most commonly used vectors in the process are:   Retroviruses   Adenoviruses Other less fre...
Risks There are a number of risk factors involved in viral gene therapy. Such problems include:   Destruction of health...
Advantages Viral gene therapy is capable of curing many diseases Providing a cost effective approach to curing Type I di...
How it Contributes to Science Viral gene therapy helps us better understand viruses It can help us understand how viruse...
Conclusion Viral gene therapy, though it has its flaws, it can indeed lead  to a better future for humanity To date, the...
Viral gene therapy
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Viral gene therapy

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Viral gene therapy

  1. 1. Viral Gene TherapyPresented by Alex Bunk
  2. 2. What It Is Viral Gene therapy is the methodic use of viruses that normally cause illness as vectors to transfer genes that will produce desired effects in patients afflicted with certain illnesses.
  3. 3. What It IsThere is a lack of an efficient non-toxic delivery system to provide the successful application of gene therapy for treatment of a range of diseases has been a major barrier to gene therapy.Viruses have evolved to deliver their genes to target cells and are considered to be the most effective means of gene delivery and have an ability to be manipulated to express therapeutic genes or to replicate specifically in certain cells. Gene therapy is being developed for a range of diseases including inherited monogenic disorders and cardiovascular disease, but it is in the treatment of cancer that this approach has been most evident, resulting in the licensing of a gene therapy for the routine treatment of head and neck cancer in China.
  4. 4. How It Works Viral gene therapy works by first removing the genes of a viral vector then replacing it with genes that will produce the desired effect.
  5. 5. What It Can Cure Viral gene therapy is capable of curing a multitude of diseases, both genetic and acquired. Diseases that viral gene therapy can cure include:  Cancer  Type 1 diabetes  Sever combined immune deficiency  Chronic granulomatous disorder  Hemophilia  Various cancers  Neurodegenerative diseases  Cystic fibrosis
  6. 6. Viral Vectors Used The two most commonly used vectors in the process are:  Retroviruses  Adenoviruses Other less frequently used viruses are:  Adeno-associated viruses  Lentiviruses  Pox viruses  Alphaviruses  Herpes viruses These viruses all differ in how well they are able to transfer genes to the cells they recognize and are able to infect, and whether they alter the cell’s DNA temporarily or permanently These viruses are displayed on the following slide.
  7. 7. Risks There are a number of risk factors involved in viral gene therapy. Such problems include:  Destruction of healthy cells in cancer treatment  Cancerous mutations due to injection at incorrect locations on DNA  Changes can be passed on to children if the reproductive cells are affected. In addition, interference from corporations that produce drugs for people with chronic illnesses, such as Medtronics who produce insulin pumps. Viral gene therapy is not supported by the entities that fund research because it would be the cure to the very diseases from which these corporations profit.
  8. 8. Advantages Viral gene therapy is capable of curing many diseases Providing a cost effective approach to curing Type I diabetes with minimal complications in comparison to a pancreas transplant. Using gene therapy abolishes the high risks of taking immunosuppressant drugs and would be assessable to a larger population pool. Currently, pancreas transplants are only available to individuals who are also eligible for a kidney transplant. Continuing to find cures for genetic diseases and possibly eliminating their existence
  9. 9. How it Contributes to Science Viral gene therapy helps us better understand viruses It can help us understand how viruses can be killed as well as how they infect certain cells If used in mass numbers, viral gene therapy has the potential of removing genetic disorders from the gene pool entirely
  10. 10. Conclusion Viral gene therapy, though it has its flaws, it can indeed lead to a better future for humanity To date, the therapeutic results of gene therapy have been minimal. This approach holds much potential, however, especially for treating single-gene disorders, and it is being actively investigated. I hope to one day see viral gene therapy replacing insulin pumps and pancreas transplants for type 1 diabetes.
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