2. INTRODUCTION TO IMMUNITY
• Immune system system of
biological structures + processes within
organism
• protects against disease.
• Organism function properly immune system
detect wide variety of agents
• (viruses, parasitic worms)
• distinguish them from own healthy tissue.
3. INNATE IMMUNE SYSTEMS
Cells + proteins always present & ready to mobilize
fight microbes at site of infection.
Main components of innate immune system:
1) physical epithelial barriers,
2) phagocytic leukocytes (WBC)
3) dendritic cells,
4) a special type of lymphocyte called a natural killer (NK) cell,
5) circulating plasma proteins.
4. If pathogens successfully evade innate response vertebrates
possess second layer of protection
acquired immune system
activated by innate response
Now immune system adapts its response during infection
improve its recognition of pathogen.
Improved response retained after pathogen eliminated
immunological memory
allows acquired immune system to act faster and stronger attacks
each time this pathogen is encountered.
6. BARRIER DEFENSE SYSTEM
Includes:
the skin
Mucus membranes of digestive-,
respiratory- urinary and reproductive
tract
oBody secretions: mucus, saliva
(lysozymes), tears, oil gland secretions,
acid in stomach, sweat.
7. Different types of phagocytic cells
Neutrophils engulf and destroy microbes
Macrophages part of the lymphatic system
and are found throughout the body
Eosinophils discharge destructive enzymes
Dendritic cells stimulate development of
acquired immunity