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Hematopioesi
s
Wedad Hasan Aljefri
Hemo: Referring to blood
cells
Poiesis: “The development or production of”
The word Hemopoiesis refers to the production &
development of all the blood cells:
 Erythrocytes: Erythropoiesis
 Leucocytes: Leucopoiesis
Hematopioesis
 First trimester of pregnancy : Yolk sac
 Second trimester : liver.
 3rd trimester : Red bone marrow
of all bones
 Adults : Red bone marrow
in flat bones
(vertebrae,sternum,iliac
Sites
Mean: (Thrombo- + -cyte, "blood clot cell")
Function: clotting factor
Diameter: 2 – 3 µm
Life Span: 8 to 9 days
Count: 150,000 to 400,000 per cubic millimeter
Thrombocytes
Erythrocytes
Mean: (Erythro- + -cyte, "red-blood cell”)
Function: O2, CO2 and PH
Diameter: 7.8 micrometers
Life Span: 100 – 120 days
Count: Male: 4.5 to 6.3, Female: 4.2 to 5.5
Leucocytes
Mean: (Leco- + -cyte, "white-blood cell”)
Function: cells of the immune system
Diameter: 12 - 17 μm
Life Span: 5 - 21 Day
Count: 4,000 – 11,000 WBCs per microliter of blood
Neutrophil
Approx. %
in adults See
also:
Blood values
Diameter (μm) Main targets Nucleus Granules Lifetime
62% 10 – 12
• Bacteria
• Fungi
Multilobed
Fine, faintly pink
(H&E stain)
6 hours – few days
(days in spleen and
other tissue)
Eosinophil
Approx. %
in adults See
also:
Blood values
Diameter (μm) Main targets Nucleus Granules Lifetime
2.3% 10 – 12
• Larger
parasites
• Modulate
allergic
inflammatory
responses
Bi-lobed
Full of pink-orange
(H&E stain)
8 – 12 days
(circulate for 4 – 5
hours)
Basophil
Approx. %
in adults See
also:
Blood values
Diameter (μm) Main targets Nucleus Granules Lifetime
0.4% 12 – 15
Release
histamine for
inflammatory
responses
Bi-lobed or tri-
lobed
Large blue
A few hours to a few
days
Monocyte
Approx. %
in adults See
also:
Blood values
Diameter (μm) Main targets Nucleus Granules Lifetime
5.3% 15 – 30
Monocytes migrate from the
bloodstream to other tissues
and differentiate into tissue
resident macrophages,
Kupffer cells in the liver.
Kidney shaped None Hours to days
Reference
1. https://en.wikipedia.org/wiki/Haematopoiesis
2. https://en.wikipedia.org/wiki/Thrombosis
3. https://en.wikipedia.org/wiki/Red_blood_cell
4. https://en.wikipedia.org/wiki/White_blood_cel
l
5. http://www.slideshare.net/Firedemon13/hem
atopoiesis

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Hematopioesis

  • 2. Hemo: Referring to blood cells Poiesis: “The development or production of” The word Hemopoiesis refers to the production & development of all the blood cells:  Erythrocytes: Erythropoiesis  Leucocytes: Leucopoiesis Hematopioesis
  • 3.  First trimester of pregnancy : Yolk sac  Second trimester : liver.  3rd trimester : Red bone marrow of all bones  Adults : Red bone marrow in flat bones (vertebrae,sternum,iliac Sites
  • 4.
  • 5. Mean: (Thrombo- + -cyte, "blood clot cell") Function: clotting factor Diameter: 2 – 3 µm Life Span: 8 to 9 days Count: 150,000 to 400,000 per cubic millimeter Thrombocytes
  • 6. Erythrocytes Mean: (Erythro- + -cyte, "red-blood cell”) Function: O2, CO2 and PH Diameter: 7.8 micrometers Life Span: 100 – 120 days Count: Male: 4.5 to 6.3, Female: 4.2 to 5.5
  • 7. Leucocytes Mean: (Leco- + -cyte, "white-blood cell”) Function: cells of the immune system Diameter: 12 - 17 μm Life Span: 5 - 21 Day Count: 4,000 – 11,000 WBCs per microliter of blood
  • 8.
  • 9. Neutrophil Approx. % in adults See also: Blood values Diameter (μm) Main targets Nucleus Granules Lifetime 62% 10 – 12 • Bacteria • Fungi Multilobed Fine, faintly pink (H&E stain) 6 hours – few days (days in spleen and other tissue)
  • 10. Eosinophil Approx. % in adults See also: Blood values Diameter (μm) Main targets Nucleus Granules Lifetime 2.3% 10 – 12 • Larger parasites • Modulate allergic inflammatory responses Bi-lobed Full of pink-orange (H&E stain) 8 – 12 days (circulate for 4 – 5 hours)
  • 11. Basophil Approx. % in adults See also: Blood values Diameter (μm) Main targets Nucleus Granules Lifetime 0.4% 12 – 15 Release histamine for inflammatory responses Bi-lobed or tri- lobed Large blue A few hours to a few days
  • 12. Monocyte Approx. % in adults See also: Blood values Diameter (μm) Main targets Nucleus Granules Lifetime 5.3% 15 – 30 Monocytes migrate from the bloodstream to other tissues and differentiate into tissue resident macrophages, Kupffer cells in the liver. Kidney shaped None Hours to days
  • 13. Reference 1. https://en.wikipedia.org/wiki/Haematopoiesis 2. https://en.wikipedia.org/wiki/Thrombosis 3. https://en.wikipedia.org/wiki/Red_blood_cell 4. https://en.wikipedia.org/wiki/White_blood_cel l 5. http://www.slideshare.net/Firedemon13/hem atopoiesis