This document provides an overview of computational neuroscience topics including neural encoding and decoding models, mechanical models of brain cells, neuron doctrine, ion channels and synaptic transmission. Key points covered are: neural encoding uses linear filters and input/output functions, receptive fields are sensory areas that produce strong neural responses, neurons are leaky bags of charged liquid, ion pumps and different channel types (mechanical, voltage, chemical) modulate neural polarization and spikes, myelin sheaths enable long-range spike communication, synapses can be excitatory or inhibitory and involve neurotransmitters modifying postsynaptic potentials, and synaptic plasticity underlies memory and learning. Major brain regions and their functions are also listed.

1. Computational neuroscience
brief(Basics)
By: Vishwas Narayan

2. Neural Encoding Model
Linear filter+input/output function

3. Neural Decoding Model
Just the input and the output units

4. Mechanical Model of the brain cells and the
simulation

5. Descriptive,Mechnaistic,Interpretive
● What ??
● How ??
● Why??

6. Receptive Field
Strong part of the sensory stimulus that produces the strong response from the
cell.

7. Neuron Doctrine

8. Idealised Neuron

9. Neurons
A leaky bag of the charged liquid(lipid bilayer)
Resting potential of -70mv

10. Ionic Pump

11. Types of channel
● Mechanical gate
● Voltage gate
● Chemical gate

12. Functions of the channel
● Depolarization
● Hyperpolarization
To be hammered strongly:
Only strong Depolarization can get the spikes to be loaded

13. Myelin sheath
Oligendrocytes or the glial cells wrap axons and enables long range spike
communication.
Node of RANVIER(Saltatory conduction)

14. Synapse
Synapse can be excitatory or inhibitory
Examples of the excitatory synapse:
● Input spike
● Glutamate binds to ion channel receptors
● Na+ flux
● Depolarization due to the excitatory postsynaptic potential

15. The Synapse Doctrine
● Synapse is a basis for memory and learning
● Hebbian synaptic plasticity
● Long term potential are being observed for days and weeks in terms of
strength
● Long term depression is observed as a decrease in the strength of the
synaptic strength

16. Major Brain Regions
● Medulla oblongata: Involuntary actions
● Pons:sleep and the arousal
● Cerebellum Vision,control
● REticular formation:Modulates brain reflexes and the otheractivity like
pain,perception.
● Thalamus:relay station for all the sensors
● hypothalamus:REgulates basic needs
● Cerebrum:(cerebral cortex,basal ganglia,hippocampus,amygdala)

17. Brain and the computer
Massive parallel v/s Sequential

18. Thank You
Any question,comments,critics anything is fine if you have understood