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A PRESENTATION ON
NEONATAL ABSTINANCE
SYNDROME
BY
Mr VINU.K.S
ASSISSTANT PROFESSOR
PEDIATRIC DEPATMENT
NAINCY COLLEGE OF NURSING
NAINITAL
Neonatal abstinence syndrome
 Neonatal abstinence syndrome (NAS) is a group of
problems that occur in a newborn who was exposed to
addictive opiate drugs while in the mother’s womb
Neonatal abstinence syndrome
Incidence
Types
 Two major types of NAS are recognized:
 prenatal or maternal
 postnatal
Etiology
 Illicit drug intake of pregnant women eg: heroin
 Exposure of foetus to alcohol, marijuana and so on
Cocaine action
Symptoms
 The symptoms of neonatal abstinence syndrome depend
on:
 The type of drug the mother used
 How the body breaks down and clears the drug
 How much of the drug she was taking
 How long she used the drug
 Whether the baby was born full-term or early (premature)
CNS dysfunction includes the following
features:
 High-pitched cry
 Restlessness, with sleep duration less than 1-3 hours after
feeding
 Hyperactive reflexes
 Jitteriness
 Tremors
 Hypertonia
 Myoclonic jerks
 Generalized convulsions
Metabolic, vasomotor, and respiratory
disturbances include the following features
 Sweating
 Fever
 Mottling
 Frequent yawning
 Respiratory rate greater than 60 breaths per minute
without retractions
 Sneezing (>3 times per interval)
 Apnoea
 Nasal flaring
GI dysfunction includes the following
features:
 Excessive (frantic) sucking
 Poor feeding
 Hyperphagia, usually associated with poor weight gain
 Regurgitation or projectile vomiting
 Loose or watery stools
Alcohol-specific symptoms include the
following:
 Neonates also exhibit irritability,
 tremors,
 seizures,
 Opisthotonos, and abdominal distention.
Exams and Tests
 History collection
 Physical examination
 Toxicology (drug) screen of urine and of first bowel
movements (meconium).
 Finnegan scoring system
Finnegan scoring system
NAS Scoring Protocol
 Initiate scoring within 2 hours of admission
 Infants should not be awakened to obtain a score
 Infants at risk of opiate withdrawal are assessed for signs
of withdrawal ½ to 1 hour after each feed
 The scoring chart is designed for term infants.
 Allowances must be made for infants who are preterm
Management
 Treatment depends on :
 the drug involved
 The infants overall health and abstinence score
 Whether the baby was born full-term or premature
Non-Pharmacologic Interventions NAS
 TLC ( tender loving care )
 Swaddling
 Rocking
 Minimal sensory or environmental stimulation
 Maintain temperature stability
 High caloric feed
 Breastfeeding
Pharmacologic Therapy
NAS
 Dilute Morphine Sulfate Oral solution
 Methadone maintenance therapy
 Clonidine
Pharmacologic therapy NAS
 Begin when 2-3 consecutive Finnegan scores are ≥8 or
when the sum of 3 consecutive Finnegan scores is ≥24
 Based upon toxicology and clinical presentation initiate
drug therapy
Pharmacologic therapy NAS
 Morphine or methadone are first-line opiates
 Clonidine is a first line or adjunctive therapy used in
combo with an opiate for poly-substance exposure
Role of nurse
 Assess the women prenatally.
 Identify the prenatal substance use of women.
 Identify women’s need.
 Assessment of baby by using Finnegan scale for
withdrawal symptom.
Role of nurse
 Assess the maternal well being and parenting skills.
 Circulate the planned discharge plan to a multidisciplinary
care team.
 Medical and psycho social assessment of mother and baby
Prevention During Preconception period:
 Promote awareness of effects of parental substance use.
 No use of alcohol and opioids when planning and during
pregnancy.
 Discuss all medicines and alcohol and tobacco use with
your health care provider
Prevention During Antenatal period:
 Screening for pregnant women to identify the substance
abuse
 provide the enhanced the referral services if necessary.
Prevention At birth:
 Use consistent and effective protocols for identification of
substance exposed newborns
 Make assurance for developmental child welfare services.
Neonatal abstinence syndrome

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Neonatal abstinence syndrome

  • 1. A PRESENTATION ON NEONATAL ABSTINANCE SYNDROME BY Mr VINU.K.S ASSISSTANT PROFESSOR PEDIATRIC DEPATMENT NAINCY COLLEGE OF NURSING NAINITAL
  • 2. Neonatal abstinence syndrome  Neonatal abstinence syndrome (NAS) is a group of problems that occur in a newborn who was exposed to addictive opiate drugs while in the mother’s womb
  • 5. Types  Two major types of NAS are recognized:  prenatal or maternal  postnatal
  • 6. Etiology  Illicit drug intake of pregnant women eg: heroin  Exposure of foetus to alcohol, marijuana and so on
  • 8. Symptoms  The symptoms of neonatal abstinence syndrome depend on:  The type of drug the mother used  How the body breaks down and clears the drug  How much of the drug she was taking  How long she used the drug  Whether the baby was born full-term or early (premature)
  • 9. CNS dysfunction includes the following features:  High-pitched cry  Restlessness, with sleep duration less than 1-3 hours after feeding  Hyperactive reflexes  Jitteriness  Tremors  Hypertonia  Myoclonic jerks  Generalized convulsions
  • 10. Metabolic, vasomotor, and respiratory disturbances include the following features  Sweating  Fever  Mottling  Frequent yawning  Respiratory rate greater than 60 breaths per minute without retractions  Sneezing (>3 times per interval)  Apnoea  Nasal flaring
  • 11. GI dysfunction includes the following features:  Excessive (frantic) sucking  Poor feeding  Hyperphagia, usually associated with poor weight gain  Regurgitation or projectile vomiting  Loose or watery stools
  • 12. Alcohol-specific symptoms include the following:  Neonates also exhibit irritability,  tremors,  seizures,  Opisthotonos, and abdominal distention.
  • 13. Exams and Tests  History collection  Physical examination  Toxicology (drug) screen of urine and of first bowel movements (meconium).  Finnegan scoring system
  • 15. NAS Scoring Protocol  Initiate scoring within 2 hours of admission  Infants should not be awakened to obtain a score  Infants at risk of opiate withdrawal are assessed for signs of withdrawal ½ to 1 hour after each feed  The scoring chart is designed for term infants.  Allowances must be made for infants who are preterm
  • 16. Management  Treatment depends on :  the drug involved  The infants overall health and abstinence score  Whether the baby was born full-term or premature
  • 17. Non-Pharmacologic Interventions NAS  TLC ( tender loving care )  Swaddling  Rocking  Minimal sensory or environmental stimulation  Maintain temperature stability  High caloric feed  Breastfeeding
  • 18. Pharmacologic Therapy NAS  Dilute Morphine Sulfate Oral solution  Methadone maintenance therapy  Clonidine
  • 19. Pharmacologic therapy NAS  Begin when 2-3 consecutive Finnegan scores are ≥8 or when the sum of 3 consecutive Finnegan scores is ≥24  Based upon toxicology and clinical presentation initiate drug therapy
  • 20. Pharmacologic therapy NAS  Morphine or methadone are first-line opiates  Clonidine is a first line or adjunctive therapy used in combo with an opiate for poly-substance exposure
  • 21. Role of nurse  Assess the women prenatally.  Identify the prenatal substance use of women.  Identify women’s need.  Assessment of baby by using Finnegan scale for withdrawal symptom.
  • 22. Role of nurse  Assess the maternal well being and parenting skills.  Circulate the planned discharge plan to a multidisciplinary care team.  Medical and psycho social assessment of mother and baby
  • 23. Prevention During Preconception period:  Promote awareness of effects of parental substance use.  No use of alcohol and opioids when planning and during pregnancy.  Discuss all medicines and alcohol and tobacco use with your health care provider
  • 24. Prevention During Antenatal period:  Screening for pregnant women to identify the substance abuse  provide the enhanced the referral services if necessary.
  • 25. Prevention At birth:  Use consistent and effective protocols for identification of substance exposed newborns  Make assurance for developmental child welfare services.

Editor's Notes

  1. NAS due to prenatal or maternal use of substances that result in withdrawal symptoms in the newborn postnatal NAS secondary to discontinuation of medications such as fentanyl or morphine used for pain therapy in the newborn.
  2. Myoclonic jerks – sudden muscle contraction
  3. Apnoea- temporary cessation of breath, specially during sleep. Mottling – blotching of skin Nasal flaring – widening of nostrils while breathing.
  4. Opisthotonos – backward arching of head, neck and spine due to muscle spasm
  5. History collection - Many other conditions can produce the same symptoms as neonatal abstinence syndrome. To help make a diagnosis, the health care provider will ask questions about the mother's drug use. The mother may be asked about which drugs she took during pregnancy, and when she last took them. The mother's urine may be screened for drugs as well. Finnegan scoring system Neonatal abstinence syndrome scoring system, which assigns points based on each symptom and its severity. The infant's score can help determine treatment.
  6. The optimal treatment for NAS has not been established. Primary treatment of neonatal symptoms related to prenatal substance exposure should be supportive because pharmacologic therapy can prolong hospitalization and exposes the infant to additional agents that are often not necessary. However, pharmacotherapy for infants with more severe expression of NAS is necessary to allow them to feed, sleep, gain weight, and interact with caregivers. Opioids are currently considered the first-line therapy. Second-line therapy has been phenobarbital. Phenobarbital has been effective for the treatment of opioid withdrawal seizures and polydrug exposure.
  7. Clonidine – alpha 2 adrenergic agonist ,which will stimulate the alpha 2 receptors in brain which reduce the peripheral vascular resistance and thus decrease the BP Methadone – its mu opioid antagonist Morphin-pail reliever.
  8. Should do the medical and psycho social assessment of mother and baby before discharge that indicate a stable condition.