6. Cisplatin Synthesis Dhara, S.C., A Rapid Method for the Synthesis of cis-[Pt(NH3)2Cl2], Indian Journal of Chemistry, vol. 8, No. 2, Feb. 1970, pp. 193-194.
7. F. Coste, J. M. Malinge, L. Serre, W. Shepard, M. Roth, M. Leng and C. Zelwer, "Crystal structure of a double-stranded DNA containing a cisplatin interstrand cross-link at 1.63 A resolution: hydration at the platinated site", Nucleic Acids Res , 1999, 27 , 1837
While studying electric fields and growth of E. Coli/// Rosenberg 1964 Group VIIIb transition metal compounds inhibit cell division 1-10ppm Growth not affected Components of the experimental medium were electrolyzed and tested for the presence of oxidizing agents by reacting with KI/starch solutions. Positive results were found for NH4Cl. NH4)2PtCl6 was formed to be the active agent.
the trans effect is the labilization of ligands trans to certain other ligands, which can thus be regarded as trans directing ligands.
F. Coste, J. M. Malinge, L. Serre, W. Shepard, M. Roth, M. Leng and C. Zelwer, "Crystal structure of a double-stranded DNA containing a cisplatin interstrand cross-link at 1.63 A resolution: hydration at the platinated site", Nucleic Acids Res , 1999, 27 , 1837
Preformed Pt- HSA (human serum albumin) administered clinically to patients there was increased survival time. Individuals with low HSA did not respond well to cisplatin Centerwall at Syracuse found using HSQC NMR N15 NMR-h1
Carboplatin cyclobutane dicarboxylate decreases reactivity. Oxaliplatin for colon cancer…oxalate increases water solubility…othermechanisms unknown
Many insecticides show cross resistance Increased reactivity with glutathione may reduce cytotoxicity
Lead compound in future studies of Pt. compounds with hydrophobic ligands. They speculate that the structure of water molecules around adamantineamine affect reaction with glutathione and thiols.
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