Clavulanate potassium is a beta-lactamase inhibitor isolated from streptomyces that binds to beta-lactamase and protects other beta-lactam antibiotics from being deactivated. It is used in combination with penicillin antibiotics to treat infections caused by bacteria that produce beta-lactamase. Crystalline potassium clavulanate can exist as rod-like or needle-like crystals or plate-like crystals, and has properties that can make processing difficult. Amoxicillin and clavulanate potassium is a combination antibiotic used to treat various bacterial infections, with amoxicillin as the penicillin antibiotic and clavulanate potassium as a beta-

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Clavulanate Potassium is a
semi-synthetic beta-
lactamase inhibitor
isolated from
streptomyces. Clavulanate
potassium contains a beta-
lactam ring and binds
strongly to beta-lactamase
at or near its active site.
This protects other beta-
lactam antibiotics from
beta-lactamase catalysis.
This drug is used in
conjunction with beta-
lactamase susceptible
penicillin to treat
infections caused by beta-
lactamase producing
organisms.

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The process for
preparing potassium
clavulanate in the form of
crystalline rosette-like
starbursts which
comprises concurrently
adding a solution of
potassium 2-ethyl
hexanoate in isopropanol
and a solution of tertiary-
butylamino clavulanate in
aqueous isopropanol to a
mixture of isopropanol
and acetone and
precipitating the
crystalline potassium
clavulanate therefrom,
and optionally isolating
the crystals by filtration.

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Crystalline potassium
clavulanate generally
exists in the form of rod-
like or needle-like
crystals, which are
generally relatively large,
long crystals, sometimes
agglomerated into plate-
like crystals, and
sometimes randomly
aggregated into loosely
formed bundles. This
form of potassium
clavulanate can give rise
to processing difficulties
in that the material does
not always flow readily, is
of low bulk density, and
can be difficult to sieve

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Amoxicillin and
clavulanate potassium is
a combination medicine
used to treat many
different infections
caused by bacteria, such
as sinusitis, pneumonia,
ear infections,
bronchitis, urinary tract
infections, and infections
of the skin.

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Amoxicillin and
clavulanate potassium is
a combination
prescription antibiotic.
Amoxicillin is a penicillin
antibiotic that fights
bacteria in the body.
Clavulanate potassium is
a beta-lactamase
inhibitor that helps
prevent certain bacteria
from becoming resistant
to amoxicillin.

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