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Anatomical variations 
from wrist to aorta and 
impact on transradial 
procedures 
Hristo Pejkov, Biljana Zafirovska, Oliver Kalpak, Sasko Kedev 
University Clinic of Cardiology, Skopje - Macedonia 
pejkovh@yahoo.com
 All authors have nothing to disclose
RA Anomalies 
 TRA is technically more challenging approach 
mostly due to anomalies of the arm arteries and 
aorta, which influence the success rate of 
angiographic procedures 
 Published data about the presence of RA anomalies 
reported percentages ranging from 7%-22% 
 The exact influence of these anomalies on TR 
success is still under investigation
RA Anomalies
Data from our database 
 Total number of 10504 consecutive patients were analysed 
over a period of 2 years (March 2011 – Juli 2013) 
 Retrograde radial arteriography was performed to define 
the radial artery anatomy from mid forearm to ulnobrachial 
anastomosis making a roadmap for the intervention.
Total Number of patients 
(10502 pts) 
RA without anomalies 
N=9388 (89,4%) 
RA anomalies group 
N=1114 (10,6%) 
High bifurcating origin of the radial artery (733 ) 
Radial artery loop (360°) (105) 
Radial artery tortuosity(152) 
Hypoplastic radial artery (17) 
Loop of the brachial/axillary/subcl. (113) 
Anomalies of the aortic arch Retroesophageal 
right subclavian artery (a.Lusoria) (6) 
Cross-over 
(52)
Anatomical variants Number of patients 
Total Number of patients with anomalies 1114 (10,6%) 
High bifurcating origin of the radial artery from the 
733 (7%) 
brachial or axillary arteries 
Radial artery loop (360°) 105 (1%) 
Radial artery tortuosity 152 (1,4%) 
Hypoplastic radial artery 17 (0,16%) 
Loop of the brachial/axillary/subclavian artery 113 (1,0%) 
Anomalies of the aortic arch 
Retroesophageal right subclavian artery (a.Lusoria) 
6 (0,05%) 
Anatomical variants
High take off RA from BA 
 7% according to our 
data 
Crossover 2%
Radial artery loop 
 1% according our data 
 22% crossover 
 The loop consists of a tight 
retrograde bend of the radial 
artery before joining the ulnar 
artery in the forearm
Complex loop with remnant artery and 
high degree spasm
Tortuosities of RA & Hypoplastic 
 Pts without previous interventions 
 0,16% according to our data 
 17% crossover 
 1,4% according to our data 
 Most prone to spasm 
 Crossover in 6,5%
a.Lusoria wire and catheter advancement 
 A.Lusoria 0,03% according to our data, 0% crossover
RA Crossover 
TR Access site crossover 
Number of 
patients 
High bifurcating origin of the radial artery from the 
brachial or axillary arteries 
15 (2%) 
Radial artery loop (360°) 23 (22%) 
Radial artery tortuosity 10 (6,5%) 
Hypoplastic radial artery 3 (17,6 %) 
Loop brachial/axillary/subclavian artery 0 (0%) 
a.Lusoria 0 (0%)
Crossover direction 
TR Access site crossover direction 
Incidence and 
prevalence N=52 pat. 
Right transulnar access 23 (44,2%) 
Left transradial access 26 (50%) 
Right transfemoral access 3 (0, 5%)
Complications & Success 
Complications 
RA anomalies group 
N=1114 (10,6%) 
RA without 
anomalies 
N=9388 (89,4%) 
P 
Value 
Clinical radial artery spasm 167 (15%) 255 (2,7%) <0,001 
Access site bleeding 
complications 
145 (13%) 850 (7,5%) <0,001 
Procedural success 1062 (95,3%) 
Cross-over 52 (4,7%) 
Haemathoma grade 1 61(5,4 %) 
Haemathoma grade 2 53 (4,7%) 
Haemathoma grade 3 32 (2,9%) 
Haemathoma grade 4 7 (0,6%) 
Haemathoma grade 5 2 (0,2%) 
Major vascular complications 0
Conclusion 
 Failure of transradial procedures is associated with 
anatomical variants located from wrist to aorta. 
 Pre-procedural radial artery angiography gives the 
operator a chance to successfully plan the strategy for 
crossing the anomaly. 
 High volume transradial centers with experienced 
transradial operators have lower transradial cross-over 
rate due to anatomical variations.
Conclusion 
 For broad application of transradial angiography or 
intervention, operator need learning curve and 
knowledge about technique and devices 
 We can overcame problems and doing well in the future 
with advancement of skills and device techniques

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Pejkov H - AIMRADIAL 2014 - Anatomical variations

  • 1. Anatomical variations from wrist to aorta and impact on transradial procedures Hristo Pejkov, Biljana Zafirovska, Oliver Kalpak, Sasko Kedev University Clinic of Cardiology, Skopje - Macedonia pejkovh@yahoo.com
  • 2.  All authors have nothing to disclose
  • 3. RA Anomalies  TRA is technically more challenging approach mostly due to anomalies of the arm arteries and aorta, which influence the success rate of angiographic procedures  Published data about the presence of RA anomalies reported percentages ranging from 7%-22%  The exact influence of these anomalies on TR success is still under investigation
  • 5. Data from our database  Total number of 10504 consecutive patients were analysed over a period of 2 years (March 2011 – Juli 2013)  Retrograde radial arteriography was performed to define the radial artery anatomy from mid forearm to ulnobrachial anastomosis making a roadmap for the intervention.
  • 6. Total Number of patients (10502 pts) RA without anomalies N=9388 (89,4%) RA anomalies group N=1114 (10,6%) High bifurcating origin of the radial artery (733 ) Radial artery loop (360°) (105) Radial artery tortuosity(152) Hypoplastic radial artery (17) Loop of the brachial/axillary/subcl. (113) Anomalies of the aortic arch Retroesophageal right subclavian artery (a.Lusoria) (6) Cross-over (52)
  • 7. Anatomical variants Number of patients Total Number of patients with anomalies 1114 (10,6%) High bifurcating origin of the radial artery from the 733 (7%) brachial or axillary arteries Radial artery loop (360°) 105 (1%) Radial artery tortuosity 152 (1,4%) Hypoplastic radial artery 17 (0,16%) Loop of the brachial/axillary/subclavian artery 113 (1,0%) Anomalies of the aortic arch Retroesophageal right subclavian artery (a.Lusoria) 6 (0,05%) Anatomical variants
  • 8. High take off RA from BA  7% according to our data Crossover 2%
  • 9. Radial artery loop  1% according our data  22% crossover  The loop consists of a tight retrograde bend of the radial artery before joining the ulnar artery in the forearm
  • 10. Complex loop with remnant artery and high degree spasm
  • 11. Tortuosities of RA & Hypoplastic  Pts without previous interventions  0,16% according to our data  17% crossover  1,4% according to our data  Most prone to spasm  Crossover in 6,5%
  • 12. a.Lusoria wire and catheter advancement  A.Lusoria 0,03% according to our data, 0% crossover
  • 13. RA Crossover TR Access site crossover Number of patients High bifurcating origin of the radial artery from the brachial or axillary arteries 15 (2%) Radial artery loop (360°) 23 (22%) Radial artery tortuosity 10 (6,5%) Hypoplastic radial artery 3 (17,6 %) Loop brachial/axillary/subclavian artery 0 (0%) a.Lusoria 0 (0%)
  • 14. Crossover direction TR Access site crossover direction Incidence and prevalence N=52 pat. Right transulnar access 23 (44,2%) Left transradial access 26 (50%) Right transfemoral access 3 (0, 5%)
  • 15. Complications & Success Complications RA anomalies group N=1114 (10,6%) RA without anomalies N=9388 (89,4%) P Value Clinical radial artery spasm 167 (15%) 255 (2,7%) <0,001 Access site bleeding complications 145 (13%) 850 (7,5%) <0,001 Procedural success 1062 (95,3%) Cross-over 52 (4,7%) Haemathoma grade 1 61(5,4 %) Haemathoma grade 2 53 (4,7%) Haemathoma grade 3 32 (2,9%) Haemathoma grade 4 7 (0,6%) Haemathoma grade 5 2 (0,2%) Major vascular complications 0
  • 16. Conclusion  Failure of transradial procedures is associated with anatomical variants located from wrist to aorta.  Pre-procedural radial artery angiography gives the operator a chance to successfully plan the strategy for crossing the anomaly.  High volume transradial centers with experienced transradial operators have lower transradial cross-over rate due to anatomical variations.
  • 17. Conclusion  For broad application of transradial angiography or intervention, operator need learning curve and knowledge about technique and devices  We can overcame problems and doing well in the future with advancement of skills and device techniques