4. Color-coded labeling makes it easy to select the right bone and/or membrane
solution from our complete line of SYMBIOS®
regenerative materials.
membrane
synthetic
SYMBIOS®
OsteoShield®
d-PTFE Non-Resorbable Membrane
SYMBIOS®
OsteoShield®
Titanium-Reinforced
d-PTFE Non-Resorbable Membrane
xenograft
SYMBIOS®
OsteoShield®
Collagen Resorbable Membrane
allograft
SYMBIOS®
PerioDerm®
Acellular Dermis
bone
allograft
DBX®
Putty
Demineralized Bone Matrix
SYMBIOS®
Mineralized
Cancellous Powder
SYMBIOS®
Mineralized
Cortical Powder
SYMBIOS®
Demineralized
Cortical Powder
SYMBIOS®
Mineralized
Cortical & Cancellous Granules
SYMBIOS®
Demineralized
Cortical & Cancellous Granules
synthetic
SYMBIOS®
OsteoGraf®
LD-300
Low-Density Hydroxylapatite
Bone Graft Material
SYMBIOS®
OsteoGraf®
D-300
Dense Hydroxylapatite Bone Graft
Material
SYMBIOS®
OsteoGraf®
D-700
Dense Hydroxylapatite Bone Graft
Material
SYMBIOS®
OsteoGraf®
Unfilled Syringes
Delivery System
xenograft
SYMBIOS®
OsteoGraf®
N-300
Dense Bovine Bone Graft Material
SYMBIOS®
OsteoGraf®
N-700
Dense Bovine Bone Graft Material
PepGen P-15®
Particulate
PepGen P-15®
FLOW
5. From a company you can trust
At DENTSPLY Implants, we share your commitment to
providing the best care for your implant patients. As
one of the world’s leading manufacturer and supplier
of dental implant solutions, everything we offer is
aimed at enhancing your clinical success, including
our comprehensive SYMBIOS®
portfolio of regenerative
products. Clinically proven over time, these versatile
products are designed to meet your needs – while
supporting your high standards for success.
Choice and performance
You know strong and stable graft integration
is crucial for predictable tissue regeneration.
How you achieve this depends greatly on your
patient and your choice of regenerative products.
Now you can reduce inconsistency and add the
predictability you need with one complete line of
regenerative products.
SYMBIOS®
– for all your regenerative needs
SYMBIOS®
is a full range of quality allograft, xenograft and synthetic bone graft
and membrane products designed to promote excellent long-term bone growth and
stability. This comprehensive offering consistently delivers predictable clinical efficacy,
biocompatibility, ease of use and safety you can rely on.
6. Our allograft partner:
Musculoskeletal Transplant Foundation (MTF)
DENTSPLY Implants is proud to partner with MTF
as the manufacturer of our allograft product.
Founded in 1987, this non-profit service
organization is the world’s largest tissue bank
accredited by the American Association of Tissue
Banks (AATB).
Unlike other tissue banks, MTF is directed by
doctors: a Board of Directors and a Medical
Board of Trustees comprised of more than 40
surgeons from world-renowned institutions. They
alone set MTF’s standards, which are among the
most stringent in the industry. The result is the most
clinically-sound, safe tissue, processed from the
most carefully selected donors, every single time.
Quality and safety assurance
Access to more donors than any other
tissue bank.
MTF maintains exclusive agreements or right-
of-first-refusal with the majority of the nation’s
organ procurement organizations – for more
quality tissue to choose from.
Industry-leading donor selection criteria.
MTF’s standards exceed those set by the
AATB, FDA and most tissue banks when it
comes to screening for cancer, illegal drug
use, maximum donor age, and a host of
other conditions.
More deferred donors than accepted.
More than 97% are deferred for not meeting
MTF’s criteria. In addition, MTF never takes
donors deferred by other tissue banks or
direct referrals from funeral homes. Only
donors from the United States are accepted
for US distribution.
Sterility control measures for a higher level
of safety.
All tissue is aseptically processed in ISO 4
(certified) clean rooms, and processes are
validated to prevent cross contamination.
Each donor is processed individually and
tracked.
7. DBX®
Putty Demineralized Bone Matrix offers the highest bone content, optimal osteoinductivity
and exceptional handling characteristics when compared to other DBM products.
Easy to use
• High molecular weight means the material
maintains its physical integrity and resists
movement under irrigation
• Ready to use out of the box, no preparation
required
• Excellent handling characteristics
• Two-year shelf life
• Convenient, ambient temperature storage
High-quality and biocompatible
• Highest demineralized bone content
available – 93% by volume
• DBX®
sodium hyaluronate carrier is a safe
and natural substance found in human
joints and ocular fluids
• Non-hemolytic – compatible with
surrounding blood cells
• pH Balanced
Proven bone formation through optimal
osteoinductivity
• DBX®
is osteoconductive, and has been
shown to have osteoinductive potential in
an appropriately designed model
• DBX Putty has been shown in the
Urist intramuscular model, confirmed
histologically to be osteoinductive and
facilitates true bone growth1
DBX®
Putty
Demineralized Bone Matrix
DBX®
Putty
Demineralized Bone Matrix
0.5 cc syringe 228005
1.0 cc syringe 228010
2.5 cc syringe 228025
1. Zhang M, Powers RM, Wolfinbarger L. Effects of Demineralization Process on the
Osteoinductivity of Demineralized Bone Matrix. J Periodontal. 1997;68: 1085-1092.
8. • Safe, 100% bone particulate
• Easy to handle
• Predictable outcomes
• Three-year shelf life
• Convenient, ambient temperature storage
• Variety of choices
SYMBIOS®
Allograft Particulate
SYMBIOS®
Mineralized
Cortical Powder
250-850 microns
0.25 cc vial 100175
0.5 cc vial 100176
1.0 cc vial 100177
3.0 cc vial 100178
SYMBIOS®
Mineralized
Cortical & Cancellous Granules
0.1-2.0 mm
0.5 cc vial 100191
1.0 cc vial 100192
SYMBIOS®
Demineralized
Cortical & Cancellous Granules
0.5-3.0 mm
0.5 cc vial 120038
1.0 cc vial 120039
SYMBIOS®
Demineralized
Cortical Powder
250-850 microns
0.25 cc vial 120075
0.5 cc vial 120076
1.0 cc vial 120077
3.0 cc vial 120078
SYMBIOS®
Mineralized
Cancellous Powder
250-850 microns
0.5 cc 400172
1.0 cc 400173
2.5 cc 400174
Easy to handle and hydrate, SYMBIOS®
Allograft Particulate
integrates with natural bone for predictability in performance.
9. SYMBIOS®
OsteoGraf®
/N
Dense Bovine Bone Graft Material
2. Internal data available upon request.
• Natural anorganic bovine-derived
microporous hydroxylapatite (no extractable
protein by test2
)
• Cell-mediated resorption
• Hydrophilic - cohesive consistency when
hydrated
• Remodels to vital bone at the same rate as
host bone
• Predictable increase of bone dimension
• Effective bone replacement graft material
alone or when mixed with autogenous bone
and/or DFDBA
SYMBIOS®
OsteoGraf®
/N-300
Dense Bovine Bone Graft Material
250-420 microns
4 each, 1.0 g vials 930000104
4 each, 3.0 g vials 930000304
SYMBIOS®
OsteoGraf®
/N-700
Dense Bovine Bone Graft Material
420-1000 microns
4 each, 1.0 g vials 930000104
4 each, 3.0 g vials 930000304
SYMBIOS®
OsteoGraf N is a sintered bovine-derived hydroxylapatite, which is conducive
to cell-mediated resorption and provides a scaffold for new bone growth, which holds
dimension until host bone takes over.
10. PepGen P-15®
Particulate
P-15 Peptide
PepGen P-15®
particulate
250-420 microns
2 each, 1.0 g vials 99U000102
4 each, 1.0 g vials 99U000104
2 each, 3.0 g vials 99U000302
PepGen P-15®
is a synthetic composite of porous
hydroxylapatite and a peptide that mimics the cell-
binding portion of Type-1 collagen. PepGen P-15
promotes the attachment of reparative cells and
directs in the regeneration of bone.
The Science of P-15 Peptide
• Tissue-engineered bone replacement graft material.
• Mimics the inorganic and organic components of
autogenous bone.
• Includes the specially designed P-15 peptide, a
synthetic biomimetic of the 15 amino acid sequence
of Type-I collagen, which is uniquely involved in
the binding of cells, particularly fibroblasts and
osteoblasts.1
• Easy to place using conventional bone grafting
techniques.
• PepGen P-15 particulate is available in the preferred
particle size range: PepGen P-15 particulate (250-
420 microns) packaged in 1-gram and 3-gram vials.
1. Bhatnagar RS, Qian JJ, Gough CA. The role in cell-binding of a a-bend within the triple
helical region in collagen b1(I) chain: Structural and biological evidence for conformational
tautomerism on fiber surface. J Biomolecular Structure & Dynamics. 1997;14:547-560.
11. PepGen P-15®
FLOW
P-15 Peptide
PepGen P-15®
FLOW is PepGen P-15®
suspended
in an inert hydrogel that provides superior handling
and ease of delivery in a gel form.
The Predictable Choice
• First and only biomimetic of autogenous bone.
• Provides superior defect fill.
• Minimizes crestal bone loss.
• Predictable, dependable long-term results.
• Histologic confirmation of bone regeneration.
• PepGen P-15 FLOW: PepGen P-15 particulate
suspended in inert biocompatible hydrogel
packaged in 0.5 cc and 1.0 cc syringes.
PepGen P-15®
FLOW
250-420 microns
2 each, 0.5 cc syringes 99U100052
4 each, 0.5 cc syringes 99U100054
2 each, 1.0 cc syringes 99U100102
4 each, 1.0 cc syringes 99U100104
12. SYMBIOS®
OsteoGraf®
LD-300
Low-density Hydroxylapatite Bone Graft Material
OsteoGraf®
LD is a synthetic bone product that
has 56% porosity and high surface area. It
is highly radiopaque and provides excellent
handling properties.
• Low density, 100% pure synthetic hydroxylapatite.
• Resorbable bone filling material.
• Solution-mediated resorption.
• Hydrophilic-cohesive consistency when hydrated.
• Maintains alveolar bone for ridge preservation.
• Readily available source of calcium for bone
regeneration.
• Effective alternative for patients who prefer a
synthetic material.
References available upon request.
SYMBIOS®
OsteoGraf®
LD-300
Low-density Resorbable
Bone Graft Material
250-420 microns
4 each, 0.5 g vials 940000054
4 each, 1.0 g vials 940000104
4 each, 3.0 g vials 940000304
13. SYMBIOS®
OsteoGraf®
D
Dense Hydroxylapatite Bone Graft Material
OsteoGraf®
D is a synthetic dense ceramic
HA and can be successfully used in dental
applications where maintenance of bulk and
contour of the restoration and the ridge is
needed.
• Dense, 100% pure synthetic hydroxylapatite.
• Nonporous, non-resorbable, permanent graft
material.
• Provides supporting matrix for bone and/or
connective tissue deposition.
• Atrophic ridges can be augmented in both
height and dimension.
• Maintains augmented dimension for esthetic
or prosthetic support.
• Reduces resorption rate of underlying bone.
• Available in two particle sizes.
SYMBIOS®
OsteoGraf®
D-300
Dense Hydroxylapatite
Non-Resorbable Bone Graft Material
250-420 microns
4 each, 1.0 g vials 920000104
SYMBIOS®
OsteoGraf®
D-700
Dense Hydroxylapatite
Non-Resorbable Bone Graft Material
420-1000 microns
4 each, 1.0 g vials 900000104
4 each, 3.0 g vials 900000304
SYMBIOS®
OsteoGraf®
Syringes
Unfilled Straight Syringes
4 each, Straight 90000S004
References available upon request.
14. SYMBIOS®
PerioDerm®
is an acellular
dermal allograft designed for predictability
in replacing damaged or inadequate tissue
in the repair, reinforcement or supplemental
support of soft tissue defects. It is minimally
processed to remove epidermal and dermal
cells while preserving the extra-cellular matrix.
The removal of viable cells and antigens
during the decellularization process minimizes
the risk of rejection and inflammation at the
surgical site. The remaining matrix serves
as a framework for cellular infiltration
and vascularization. SYMBIOS PerioDerm
Acellular Dermis has been shown to support
the migration of host cells from wound
margins and surrounding tissues.
Minimally processed
SYMBIOS®
PerioDerm®
Acellular Dermis
undergoes a three-phase process that gently
cleans, decellularizes and disinfects without
cross-linking or compromising the integrity of
the dermal matrix. This proprietary process
results in a product that passes United States
Pharmacopeia USP<71> Sterility Tests.
Step 1. Sodium Chloride
SYMBIOS®
PerioDerm®
Acellular Dermis is
soaked in a sodium chloride solution that
promotes plasmolysis, removing the epidermis
and disrupting cells while leaving the
extracellular matrix intact.
Step 2. Triton
SYMBIOS®
PerioDerm®
Acellular Dermis
is washed in Triton, a mild detergent that
removes cellular debris to reduce surgical site
inflammation and rejection.
Step 3. Disinfection
The disinfection process provides a 6.0 log 2
(nearly a million-fold) reduction in microbial
levels, including bacteria, fungi, spores, mold,
yeast, and a 4-6 log 2 reduction of viral load,
minimizing disease transmission and cross
contamination.
SYMBIOS®
PerioDerm®
Acellular Dermis
15. The SYMBIOS®
PerioDerm®
Advantage:
• Excellent handling characteristics, similar
to autologous human skin grafts.
• Rehydrates quickly, reducing surgery time
and cost.
• Freeze-dried grafts require no refrigeration
and provide more storage options.
• Three-year shelf life reduces need for
inventory management.
• Over 90% thickness consistency for
uniform revascularization and aesthetic
results.
• No cross-linking for ready incorporation
and less risk of surgery site inflammation
and rejection.
SYMBIOS®
PerioDerm®
Acellular Dermis
Thin: .4 mm – .8 mm
1 cm x 1 cm 790101
1 cm x 2 cm 790102
1 cm x 4 cm 790104
2 cm x 2 cm 790202
2 cm x 4 cm 790204
SYMBIOS®
PerioDerm®
Acellular Dermis
Thick: .8 mm – 1.7 mm
1 cm x 1 cm 791101
1 cm x 2 cm 791102
1 cm x 4 cm 791104
2 cm x 4 cm 791204
When positioned as shown with the notch in the
upper left-hand corner, the epidermal side of the
tissue is facing up.
16. This resorbable tissue matrix made from Type-I bovine collagen delivers predictability in
performance in dental surgery procedures, in the area of a dental implant, bone defect or
ridge reconstruction.
• Longer, predictable 26- to 38-week resorption time.
• Manufactured from highly purified Type-I bovine
Achilles tendon for safety.
• Multi-layer construction assists healing of bone and
surrounding tissue while inner layers help prevent
cellular and bacterial down growth.
• Unique fiber orientation provides for unusually
high tensile strength and for stable performance
with sutures or resorbable tacks.
• Optimized flexibility for excellent wet handling,
while still allowing maintenance of space.
• Either side may be placed on the site.
SYMBIOS®
OsteoShield®
Collagen Resorbable Membrane
In Vivo Rate of Resorption Study*
SYMBIOS OsteoShield
Collagen Resorbable Membrane
100
80
60
40
20
0
0 4 8 12 16 20 24 28 32 36
*Data on FileImplant Time (weeks)
%ofImplantremaining
SYMBIOS®
OsteoShield®
Collagen Resorbable Membrane
2 each, 15x20 mm OSCRM1520
2 each, 20x30 mm OSCRM2030
2 each, 30x40 mm OSCRM3040
17. This non-resorbable yet easily removable d-PTFE membrane is designed for use with
extraction site grafting, large bony defects and where primary closure is not possible
or desired.
SYMBIOS®
OsteoShield®
d-PTFE Non-Resorbable Membrane
SYMBIOS®
OsteoShield®
d-PTFE Non-Resorbable Membrane
10 each, 12x24 mm OSNRM1224
4 each, 25x30 mm OSNRM2530
• Primary closure is not required. This membrane
is virtually impervious to bacteria, resulting in
minimal risk of bacterial invasion.
• By avoiding releasing incisions and primary
closure, the membrane maintains soft tissue
architecture, preserves keratinized mucosa
and requires minimal flap reflection or
dissection.
• The exposed membrane may be easily
removed non-surgically with a gentle tug.
• Medical grade d-PTFE is biocompatible and
non-reactive.
• Micro-machined surface texture facilitates
cell adhesion, enhances membrane stability,
reduces flap retraction and increases pull-out
strength.
18. This titanium-reinforced membrane is designed for use
with large defects, two- or three-walled defects, or
where space-making is required. It has all the benefits
of SYMBIOS®
OsteoShield®
d-PTFE Non-resorbable
Membrane plus:
• Self-supporting titanium-reinforcement, which helps
create additional space, especially in defects with
deficient bony architecture.
• Titanium-reinforcement prevents folding or wrinkling.
• Grade 1 titanium, which is flexible, for easy
membrane shaping.
SYMBIOS®
OsteoShield®
Titanium-reinforced
d-PTFE Non-resorbable Membrane
4 each, 12x20 mm OSTRNRM1220
2 each, 25x30 mm OSTRNRM2530
SYMBIOS®
OsteoShield®
d-PTFE Titanium-reinforced Non-resorbable Membrane
19. SYMBIOS®
from DENTSPLY Implants
SYMBIOS®
regenerative materials provide
predictability in performance – from a
company you can count on to serve your
needs. DENTSPLY Implants makes it easy
for you to get the kind of support you need,
when you want it.
For more information, contact your local
DENTSPLY Implants representative, register
for one of our CE programs or visit
www.dentsplyimplants.com.
BoneCollector
A re-usable option for the harvesting of
valuable bone chips during preparation of
the implant site. It is used in conjunction with
disposable titanium filters and suction tubes,
that are sold separately.
BoneTrap™
You can quickly and easily collect the
patients’ own bone during implant
surgery. BoneTrap is disposable and
delivered sterile, eliminating the need
for cleaning and sterilization
MicrowSaw
With its precise, minimally-invasive
osteotomy line, the MicroSaw sets new
standards in fast and atraumatic harvesting
of bone blocks and flaps. The MicroSaw is
part of a comprehensive set of instruments
designed to support successful augmentation
with autogenous bone.
For your autograft needs, DENTSPLY Implants also provides:
