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ADHD in Adults:                                                  Conflict of interest disclosure:
     Criteria, Comorbidities,                                  I will be discussing some research that I completed while working
                                                                   as the Director of Education and Research for The TOV    A
           and Caveats                                            Company, publisher of the Test of Variables of Attention™
                                                              (T.O.V.A.), which I will be talking about later in this presentation.

                   Steve Hughes, PhD, LP, ABPdN                  While I view my comments and opinions as expressed to be
           Assistant Professor of Pediatrics and Neurology    accurate, you should judge the facts and materials for yourself and
            Division of Pediatric Clinical Neurosciences
                                                              make an independent decision regarding your choice of diagnostic
              University of Minnesota Medical School
                                                                                    and related techniques.




              Today’s Presentation

!   Suitability of DSM-IV-TR criteria for Attention-Deficit/
    Hyperactivity Disorder in adults
                                                                                     CRITERIA
!   Proposed new DSM-V criteria for ADHD in adults

!   Adults ADHD and Comorbidities

!   Important considerations in diagnosing ADHD in adults
ADHD in DSM-IV-TR

                                                                  !   Predominantly Inattentive Type (314.00)

                                                                  !   Predominantly Hyperactive-Impulsive Type (314.01)

                                                                  !   Combined Type (314.01)

                                                                  !   ADHD Not Otherwise Specified (314.9)




          A. Inattentive Symptoms                                            A. Inattentive Symptoms
!   Often does not give close attention to details or makes       !   Often avoids, dislikes, or doesn't want to do things that
    careless mistakes in schoolwork, work, or other activities.       take a lot of mental effort for a long period of time (such
!   Often has trouble keeping attention on tasks or play              as schoolwork or homework).
    activities.                                                   !   Often loses things needed for tasks and activities (e.g.
!   Often does not seem to listen when spoken to directly.            toys, school assignments, pencils, books, or tools).
!   Often does not follow instructions and fails to finish
                                                                  !   Is often easily distracted.
    schoolwork, chores, or duties in the workplace (not due to    !   Is often forgetful in daily activities.
    oppositional behavior or failure to understand
    instructions).
!   Often has trouble organizing activities.
B. Hyperactive/Impulsive                                       B. Hyperactive/Impulsive
                 Symptoms                                                       Symptoms
!   Often fidgets with hands or feet or squirms in seat.        !   Often blurts out answers before questions have been
                                                                   finished.
!   Often gets up from seat when inappropriate.
                                                               !   Often has trouble waiting one’s turn.
!   Often runs about or climbs excessively (adolescents or
    adults, may be limited to feelings of restlessness).       !    Often interrupts or intrudes on others (butts into
                                                                   conversations or games).
!   Often has difficulty playing quietly.
!   Is often “on the go” or acts as if “driven by a motor”.
!   Often talks excessively.




                Additional Criteria                                                Rates of ADHD
!   Six or more of A and/or B.                                 !   One of the most common psychiatric disorders in children
                                                                   and adolescents
!   Some symptoms that cause impairment were present before
    age 7 years.                                               !   Worldwide prevalence about 5.3 percent
!   Some impairment from the symptoms is present in two or     !   In US, 7.8 percent of all school-aged children (about 4.4
    more settings (e.g. at school/work and at home).               million) aged 4 to 17 years diagnosed with ADHD at some
                                                                   point in their lives (CDC)
!   There must be clear evidence of significant impairment in
    social, school, or work functioning.                       !   The disorder affects 4.4 to 5 percent of US adults aged 18 to 44
!   The symptoms are not better accounted for by another       !   Approximately 9.8 million adults believed to have ADHD
    mental disorder (e.g. Mood Disorder, Anxiety Disorder,     !   (National Comorbidity Survey Replication; Barkley, Murphy,
    Dissociative Disorder, or a Personality Disorder).             & Fischer, 2008)
Diagnosis can be relatively
              straightforward….                                    Q: What do these all have in common?
                                                                   • Depression                     • Language disorder
!   Interview
                                                                   • Oppositional Defiant Disorder   • Physical or sexual abuse
!   Patient observation                                            • Anxiety disorder               • Post-Traumatic Stress Disorder
!   Child Behavior Checklist (parent and teacher)                  • Learning disability            • Head injury
                                                                   • Tourette disorder              • Neurological disorder
!   Conners Parent and Teacher Rating Scales                       • Poor social history            • Intellectual precocity/
!   ADD-H: Comprehensive Teacher Rating Scale (ACTeRS)             • Lead poisoning                   impairment
                                                                   • Hearing impairment             • Dementia
!   Vanderbilt Assessment Scales                                                                    • Family style
                                                                   • Auditory processing problems

                                                          but...
    American Academy of Child and Adolescent Psychiatry            • Sleep problems                 • Poor school/job “fit”


                                                                     A: They are all mistaken for ADHD.



                                                                                    ADHD in Adults?

                                                                   DSM-IV-TR ADHD was built for
 Without careful, comprehensive enough                                   use with children
 evaluation, almost anything that sends a
person off the rails can look like “ADHD.”
DSM-IV-TR ADHD was built for
                                                                        use with children
                                                              !   Rate of ADHD does decline with age
                                                              !   Decline is evident if using threshold cut-scores from
                                                                  questionnaires (e.g., 93rd or 98th percentile)
                                                              !   Evidence suggests normalization in around 50% of
                                                                  patients followed longitudinally
                                                              !   Full recovery seen in about 35%
                                                              !   However, strict application of DSM-IV-TR criteria at
                                                                  transition to adulthood causes dramatic drop in diagnosis
                                                                  (up to 74%)




    DSM-IV-TR ADHD was built for                                  DSM-IV-TR ADHD was built for
          use with children                                             use with children
!   DSM-IV-TR criteria were never validated in older          !   DSM-IV-TR subtypes have no apparent merit for use in
    adolescents and adults                                        adults
!   Symptom threshold / wording / conceptualization all       !   “Impairment” is often subjective
    developed for children                                    !   “Impairment” should not be relative to a high-functioning
!   Stipulation of areas of impairment not broad enough for       specialized peer group or to IQ
    older adolescents and adults
                                                              !   “Style” ≠ “Impairment”
!   No real guidelines for determining “impairment”
                                                              !   For a variety of reasons, self-report is an unreliable
!   Age 7 criterion was wholly unempirical in origin and          method to ascertain the presence of symptoms
    severely limits use in adolescents adults
Additional considerations                                       Additional considerations
!   ADHD is a symptom-complex not a disorder                    !   ADHD is confusing
!   Multiple etiologies, treatments and prognoses               !   Ability to “hyper focus” is not addressed
!   Diagnostic criteria are behavioral and subjective           !   “Executive functions” not in description, yet commonly
                                                                    affected
!   “Impairment” is subjectively determined
!   Symptoms are situation specific, age-linked, and culture
    bound
!   Symptoms often become manifested after age 7
!   Symptoms are clearly age linked




                                                                             Rethinking ADHD….
              Adjusting DSM-IV-TR
!   Diagnostic threshold must be adjusted for age
!   Current report of 4 or more symptoms from either list, or
    a total of 7 symptoms from the 18 DSM-IV-TR
    symptoms:
    !   Rules out 100% of community control group
    !   Rules in 87% of ADHD group
    !   But also rules in 70% of clinical control group!

                                                                                          Barkley (2006)
“CPTsville”                                                       Proposed DSM-V Adult ADHD
                                                                                 symptoms
                                                                        !   Often easily distracted by extraneous stimuli or irrelevant
                                                                            thoughts
                                                                        !   Often makes decisions impulsively
                                                                        !   Often has difficulty stopping activities or behavior when
                                                                            should do so
                                                                        !   Often starts projects or tasks without reading or listening to
                                                                            directions carefully
                                                                        !   Often has poor followthrough on promises or commitments he
                                                     (Also here)            or she may make to others

                        After Barkley (2006)                            !   Often has trouble doing things in proper sequence




Proposed DSM-V Adult ADHD                                                   Possible DSM-V Adult ADHD
         symptoms                                                                     symptoms
!   Often drives with excessive speed                                   !   Some impairment present in childhood or adolescence (before
                                                                            age 16)
!   Often has difficulty sustaining attention in tasks or leisure time
    activities                                                          !   Some impairment present in two or more settings (work,
                                                                            educational activities, home life, community functioning, social
!   Often has trouble organizing tasks and activities                       relationships)
    Barkley, Murphy & Fischer (2008)                                    !   Clear evidence of clinically significant impairment in multiple
                                                                            areas of functioning




                                                                            Barkley, Murphy & Fischer (2008)
COMORBIDITIES




             Comorbidity in children
                 1216 BIOL PSYCHIATRY 2005;57:1215–1220                                                                                   Comorbidity in children
                                                                                                                                                 J. Biederman



                                                                                                                         !   Almost one-third of children with ADHD have more than
                                                                                                                             one comorbid condition.

                                                                                                                             DOHHS, Agency for Healthcare Research and Quality



                                                                                           Figure 2. Approximate prevalence of comorbid diagnoses in adults with
                                                                                           attention-deficit/hyperactivity disorder.
                 Figure 1. Approximate prevalence of comorbid diagnoses in children with
                 attention-deficit/hyperactivity disorder.                               2004). Lifetime prevalence rates of comorbid anxiety disorders in
                                                                                        adults with ADHD approach 50%, whereas mood disorders,
Biederman J. (2005). Attention-Deficit/hyperactivity disorder: A selective overview. Biolantisocial disorders, and alcohol/drug dependency also show
                 three domains; 20% did well in all three domains; and 60% had           Psychiatry
57, 1215-1220.   intermediate outcomes. These findings suggest that the syn-            substantial prevalence rates (Figure 2) (Biederman et al 1993,
                 dromic persistence of ADHD is not associated with a uniform            1994; Shekim et al 1990). Findings from a new, large sample of
                 functional outcome; rather, it leads to a wide range of emotional,     male and female adults with and without ADHD provide com-
                 educational, and social adjustment outcomes that can be partially      pelling evidence for the validity of adult ADHD and document
                 predicted. More work is needed, however, to disentangle the            strikingly similar phenotypic features of the disorder in both
                 role of treatment on outcome.                                          genders (Biederman et al 2004). Consistent with previous find-
                                                                                        ings, this study documented high rates of mood and anxiety
215–1220                           Comorbidity in Adults                                J. Biederman                   Q: What do these all have in common?
                                                                                                                       • Depression                     • Language disorder
                                                                                                                       • Oppositional Defiant Disorder   • Physical or sexual abuse
                                                                                                                       • Anxiety disorder               • Post-Traumatic Stress Disorder
                                                                                                                       • Learning disability            • Head injury
                                                                                                                       • Tourette disorder              • Neurological disorder
                                                                                                                       • Poor social history            • Intellectual precocity/
                                                                                                                       • Lead poisoning                   impairment
                                                                                                                       • Hearing impairment             • Dementia
                                  Figure 2. Approximate prevalence of comorbid diagnoses in adults with
                                  attention-deficit/hyperactivity disorder.                                             • Auditory processing problems   • Family style
d diagnoses in children with                                                                                                                            • Poor school/job “fit”
                                  2004). Lifetime prevalence rates of comorbid anxiety disorders in                    • Sleep problems
                            adults with ADHD approach 50%, whereas mood disorders,
             Biederman J. (2005). Attention-Deficit/hyperactivity disorder: A selective overview. Biol Psychiatry
 domains; and57, 1215-1220. antisocial disorders, and alcohol/drug dependency also show
              60% had
  suggest that the syn-           substantial prevalence rates (Figure 2) (Biederman et al 1993,                         A: They are all mistaken for ADHD.
 ociated with a uniform           1994; Shekim et al 1990). Findings from a new, large sample of
wide range of emotional,          male and female adults with and without ADHD provide com-
 mes that can be partially        pelling evidence for the validity of adult ADHD and document
 ver, to disentangle the          strikingly similar phenotypic features of the disorder in both
                                  genders (Biederman et al 2004). Consistent with previous find-

                                                                                                                             Best practice: Multi-method
                                  ings, this study documented high rates of mood and anxiety
                                  disorders in adults with ADHD, with a female predominance.


 cal feature observed in
 n children, psychiatric
                                  Genetics and ADHD
                                  Familial Influence
                                                                                                                                assessment approach
de oppositional defiant               Family studies of ADHD have consistently supported its
ders (both unipolar and           strong familial nature (Faraone and Doyle 2001; Faraone and                      !   Must consider rule-outs and comorbidities
 disorders (Kessler 2004;      “The goal1995). Despite nosologic changes, thereis to provide a
                                  Tsuang of a comprehensive evaluation is remarkable
 bidity can occur due to
 nd Rutter 1991), recent
                                model oras between early(Cantwell 1972; Morrison and Stewart
                                  agreement
                                  defined
                                                                studies of children whose illness was
                                             diagnosis that: (a) accurately characterizes an
                                               hyperactivity
                                                                                                                   !   Must ascertain DSM-IV-TR symptoms of ADHD
 artifacts cannot explain      individual’s functioning; (b) facilitates thinkingDSM-III-R
                                  1971) and subsequent studies using DSM-III and about the
 ty observed for ADHD          individual; (c) explains his or (Biederman et al 1990; Faraone
                                  definitions of ADHD (Figure 3) her current difficulties; and
                                                                                                                   !   Should establish a baseline for treatment monitoring
 the prevalence rates of          et al 1992; Frick et al 1991; Schachar and Wachsmuth 1990). Most
                                   (d) guides effective intervention” (Hughes, 2008).
hood ADHD and how                 family studies have identified a two- to eightfold increase in the               !   Should address ongoing need for treatment
 t to gender (Biederman           risk for ADHD in parents and siblings of children with ADHD
 t al 1999).                      (Biederman et al 1990; Cantwell 1972; Faraone et al 1992; Frick                  !   Should include multimodal treatment strategy
 pact of gender on the            et al 1991; Manshadi et al 1983; Morrison and Stewart 1971; Pauls
  al (2002) reported that         et al 1983; Schachar and Wachsmuth 1990; Welner et al 1977). A
or comorbid disruptive            study of siblings of adults with ADHD (Manshadi et al 1983) and
                                                                                                                   !   May require case coordination
HD. Because disruptive
nding might explain the                                                                                            !   May require reformulation if “model” does not provide
ale ratio between clinic-
 mples of children with
                                                                                                                       predicted outcomes
ore, this gender discrep-
 ght be under-identified
“Clinicians should consider utilizing several methods of
establishing impairment, such as a combination of patient-reported
  history, corroboration through others who know the patient well,
                                                                     CAVEATS
    and archival records that may reflect such impairment, as in
 school, medical, mental health, employment, criminal and driving
       records” (p. 39-40, Barkley, Murphy & Fischer, 2008).




   Under-reporting of symptoms
           Malingering
ADHD and under-reporting                                         ADHD and under-reporting
!   ADHD symptoms may be overlooked in persons being               “Patients may also lack insight into their problems and
    treated for other psychiatric illness                          assume that their ADHD symptoms are personality or
!   Some patients are hesitant to admit to “poor character”        character traits. They may not understand the manner in
                                                                   which ADHD symptoms appear in an adult. For these and
                                                                   other reasons, patients may fail to mention ADHD
                                                                   symptoms to their healthcare provider unless they are
                                                                   specifically asked” (p. 978, Barkley & Brown, 2008).




         A young man I’ll call Alex recently graduated from
         Harvard. As a history major, Alex wrote about a dozen
         papers a semester. He also ran a student organization,
         for which he often worked more than forty hours a
         week; when he wasn’t on the job, he had classes.
         Weeknights were devoted to all the schoolwork that he
         couldn’t finish during the day, and weekend nights
         were spent drinking with friends and going to dance
         parties. “Trite as it sounds,” he told me, it seemed
         important to “maybe appreciate my own youth.” Since,
         in essence, this life was impossible, Alex began taking
         Adderall to make it possible.

         From“Brain Gain: The underground world of
         neuroenhancing drugs.” The New Yorker, April 27,
         2009.
Malingering is a big problem in             Malingering is a big problem in
          adult ADHD work                             adult ADHD work
!   Adults malinger to obtain:              !   Special dispensations
    !   Medication to sell or trade             !   Extended time on exams
    !   Medication to abuse                     !   Reduced work load
    !   Medication for “neuroenhancement”




    Malingering is a big problem in
                                                         ADHD and Malingering
          adult ADHD work
!   To win lawsuits
                                                !   Rates of symptom exaggeration / malingering may
                                                    approach 50% among treatment seeking college
                                                    students
                                                !   “...clinicians who rely upon self-report measures in the
                                                    absence of performance-based symptom validity
                                                    measures in ADHD assessment are probably risking far
                                                    more false-positives than they suspect” (Sullivan, May,
                                                    & Galbally, 2007)
Self-report is easily faked
    “In analyzing the performance of students simulating
    ADHD, and comparing it to performance of both non-
                                                                                                     Heilbronner, R.L., Sweet, J.J., Morgan, J.E., Larrabee, G.J., Millis, S.R.
    ADHD and genuine ADHD students, this study clearly                                               (2009). American academy of clinical neuropsychology consensus
    demonstrated that the symptoms of ADHD are easily                                                conference statement on the neuropsychological assessment of effort,
                                                                                                     response bias, and malingering. The Clinical Neuropsychologist, 23,
    fabricated, and that simulators would be
                                                                                                     1093-1129.
    indistinguishable from those with true ADHD” (p. 577,
    Harrison, Edwards & Parker, 2007).




           Some of the recommendations
    The evaluation of self-reported symptoms is best accomplished using
                                                                                                   Development of the T.O.V.A.
!

    psychometric instruments containing proven validity measures.
!   If possible clinicians should use multiple validity measures covering
    multiple domains distributed throughout the testing.
                                                                                                   Symptom Exaggeration Index
!   If testing must be brief (e.g., Social Security disability evaluations),
    minimally, embedded effort indicators should be examined.
!   Stand-alone effort measures and embedded validity indicators should
    both be employed.

     Heilbronner, R.L., Sweet, J.J., Morgan, J.E., Larrabee, G.J., Millis, S.R. (2009). American
     academy of clinical neuropsychology consensus conference statement on the
     neuropsychological assessment of effort, response bias, and malingering. The Clinical
     Neuropsychologist, 23, 1093-1129.
The Clinical Neuropsychologist, 19: 121–129, 2005
                                                                                                                                                                                                                       Copyright # Taylor and Francis Ltd.
                                                                                                                                                                                                                       ISSN: 1385-4046
                                                                                                                                                                                                                       DOI: 10.1080=13854040490516604




                                                                                                                                                      Downloaded By: [University of Minnesota] At: 04:18 3 June 2007
                                                              Archives of Clinical Neuropsychology
                                                                       17 (2002) 335 – 342

                                                                                                                                                                                                                                       PROBABLE MALINGERING AND PERFORMANCE
                                                                                                                                                                                                                                       ON THE TEST OF VARIABLES OF ATTENTION

                                                                                                                                                                                                                                       George K. Henry
                                   Fake bad test response bias effects on the                                                                                                                                                          Los Angeles Neuropsychology Group, Los Angeles, CA, USA

                                        test of variables of attention$                                                                                                                                                                Fifty subjects with mild head injury involved in personal injury litigation and 2 subjects
                                                                                                                                                                                                                                       referred for evaluation of their disability status underwent comprehensive neuropsycholo-
                          Robert A. Leark*, Dennis Dixon, Tiffany Hoffman, Donna Huynh                                                                                                                                                 gical examination including the Test of Variables of Attention (TOVA). Group status
                                                                                                                                                                                                                                       was determined by performance on symptom validity testing. Twenty-six subjects who
                                  Psychology Department, Pacific Christian College, 2500 East Nutwood Avenue,                                                                                                                          failed symptom validity testing formed the probable malingering (PM) group, while 26
                                                          Fullerton, CA 92831, USA                                                                                                                                                     subjects who passed symptom validity testing comprised the not malingering (NM)
                                                                                                                                                                                                                                       group. Subjects in the PM group performed significantly worse on all TOVA variables
                                                             Accepted 5 February 2001                                                                                                                                                  relative to subjects in the NM group. Discriminant function analyses revealed that TOVA
                                                                                                                                                                                                                                       omission errors 3 errors was the best predictor of group status. Malingering research
                                                                                                                                                                                                                                       employing a group of probable clinical malingerers has direct generalizability to real-
                                                                                                                                                                                                                                       world settings.
                   Abstract

                      This study investigated the effects of faking bad (FB) on the Test Of Variables of Attention
                   (TOVA) using subjects randomly placed into two groups. Subjects in Group 1 took the TOVA under                                                                                                      INTRODUCTION
                   normal conditions (NC) first; they were then requested to subtly fake bad. Group 2 subjects took the                                                                                                      Neuropsychologists are increasingly being called upon to render expert opi-
                   TOVA under the same fake bad instructions first, then took the test under normal conditions the                                                                                                     nions in the forensic area. The science upon which these opinions are based must
                   second time. An analysis of the effects of test order yielded non-significant differences for basic                                                                                                 meet acceptable standards of reliability and validity. Confidence in the reliability
                   TOVA variables across all four quarters, both halves and the total score. An analysis for group mean                                                                                                and validity of the test data generated during the neuropsychological evaluation is
                   differences between the NC and the FB instructions yielded significant differences across the basic                                                                                                 directly related to the examinee’s effort. In recent years the development of symp-
                   TOVA variables across the four quarters, two halves and total score. The FB group had excessive                                                                                                     tom validity tests (SVTs) such as the Test of Memory Malingering (TOMM;
                   amounts of omission and commission errors, a greater response time mean (i.e., slower to respond)                                                                                                   Tombaugh, 1996), Word Memory Test (WMT; Green, Allen,  Astner, 1996),
                   and had greater variance around their mean response time. The study affirms that the professional                                                                                                   and Computerized Assessment of Response Bias (CARB; Condor, Allen, 
                   using the TOVA needs to carefully eliminate a fake bad test-taking bias when subjects produce                                                                                                       Cox, 1992) have emerged on the scene to assist clinicians in objectively measuring
                   excessive test results. D 2002 National Academy of Neuropsychology. Published by Elsevier                                                                                                           one’s effort. There has also been a growing interest in developing effort indices on
                   Science Ltd.                                                                                                                                                                                        standardized neuropsychological tests in order to provide additional data on
                                                                                                                                                                                                                       which to base effort opinions (Suhr  Boyer, 1999; Mittenberg, Rotholic, Russell, 
                   Keywords: TOVA; Continuous performance test; CPT; Fake bad                                                                                                                                          Heilbronner, 1996; Greiffenstein, Baker,  Gola, 1996; Millis, Putnam, Adams, 
                                                                                                                                                                                                                       Ricker, 1995; Mittenberg et al., 2001), but also to control for attorney coaching.
                                                                                                                                                                                                                       One survey of 70 attorneys (Wetter  Corrigan, 1995) found that 79% believed
                                                                                                                                                                                                                       that a discussion with the client about what psychological testing involves should
                                                                                                                                                                                                                       take place prior to evaluation, while 47% reported that the attorney should

                       $
                                                                                                                                                                                                                              Address correspondence to: George K. Henry, Ph.D.=ABPP-CN, Los Angeles Neuropsychology
                         Portions of this paper were presented as a poster paper at the 19th Annual Meeting of the National Academy                                                                                    Group, 1950 Sawtelle Blvd., Suite 342, Los Angeles, CA 90025, USA. Tel.: 310 457 0777. Fax: 310 457
                   of Neuropsychology, San Antonio, TX, November 1999. The TOVA Research Foundation supplied use of the test                                                                                           0777. E-mail: GHenry0249@aol.com
                   for this research project.                                                                                                                                                                                 Accepted for publication: April 15, 2004.
                       * Corresponding author. Tel.: +1-714-879-3901; fax: +1-714-879-1041.
                       E-mail address: bleark@hiu.edu (R.A. Leark).
                                                                                                                                                                                                                                                                           121
                   0887-6177/02/$ – see front matter D 2002 National Academy of Neuropsychology.
                   PII: S 0 8 8 7 - 6 1 7 7 ( 0 1 ) 0 0 11 8 - 4




Leark et al. (2002)                                                                                                                   Henry (2005)
!   36 college students counterbalanced “good effort” and                                                                             !   52 personal injury litigants
    “fake bad” conditions                                                                                                             !   26 Classified as “Probably Malingering”
!   Excessive:                                                                                                                        !   26 classified“Not Malingering” based on established SVTs
!   Commission Errors (raw score = 14 +/- 17)                                                                                         !   PM showed Excessive:
!   Omission Errors (raw score = 25 +/- 27)                                                                                           !   Commission Errors (Raw score = 21 +/- 39)
!   RT Variability (227 +/- 118 ms)                                                                                                   !   Omission Errors (raw score = 54 +/- 72)
                                                                                                                                      !   RT Variability (230 +/- 94 ms)
Goals for TOVA SEI
                    !   Extend current research
                    !   Leverage accurate RT measurement
                    !   Seek obligatory differences between good effort and “fake
                        bad”
                    !   Identify subtle vs. obvious “tells”
                    !   Yield probabilistic interpretation based on sum of
                        multiple indicators
From Henry (2005)   !   Differentiate “exaggeration” from frank malingering




                                         Valid TOVA Pattern
                                     Acceptable RT Variability




                               Evidence of Post-error Slowing



                             Non-excessive Errors (raw score)
Edith Kaplan, PhD
                                                                                                                    (February 16, 1924 - September 3, 2009)

                                                                                                                 “Edithʼs Rule”
                                                                                              Commission Error RT should be  Correct Response RT




                                                                           Using the Test of Variables of Attention (T.O.V.A.TM) to Detect Deliberate Poor Performance During Assessment of Attention
                                                                                                      Steven J. Hughes1, Robert A. Leark2, George K. Henry3, Ellen L. Robertson4, Lawrence M. Greenberg1
                                                                                                         1The   TOVA Company, Los Alamitos, CA; 2Pacific Christian College, Fullerton, CA; 3Los Angeles Neuropsychology Group, Los Angeles, CA;
                                                                                                                                                         4Flaro   and Associates, Edmonton, Alberta




Within subject RT profile
                                                                                     ABSTRACT                                           a cut score of  3 Omission Errors yielded a sensitivity of 88.5% and a          established SVTs (WMT  MSVT; Green 2003, 2008). Valid RT profiles
                                                                                                                                        specificity of 80.8% in predicting PM versus probably Not Malingering            were seen in 11 cases (31%). There was no discernable pattern of SVT
                                                       Efforts to exaggerate impairment through intentionally poor                      (NM; a matched group of individuals who passed symptom validity                  performance observed between specific T.O.V.A. SV rules and the
                                                       performance can adversely affect the results of Continuous                       tests).                                                                          results of the SVTs.
                                                       Performance Tests (CPTs). Previous research with the T.O.V.A.TM has
                                                       identified extreme error scores and high reaction time variability as           These studies showed that extreme error rates are useful in identifying                                               DISCUSSION
                                                       characteristics of deliberate poor performance (Leark, Dixon, Hoffman           persons attempting to exaggerate impairment on the T.O.V.A. However,
                                                        Huynh, 2001; Henry, 2005). Further analysis of these data sets                with simple coaching, motivated malingerers could easily reduce error             Combination of “overt” signs of symptom exaggeration based on
                                                       shows that differences in error and post-error reaction times (RTs) can         rates to a more “typically impaired” level, thereby reducing their                extreme error scores and “subtle” signs based on intra-subject reaction
                                                       also distinguish valid T.O.V.A. protocols from those obtained under             likelihood of being identified.                                                   time differences shows promise as a method to improve detection of
                                                       conditions of symptom exaggeration. A preliminary T.O.V.A. symptom                                                                                                deliberate fake bad responding on the T.O.V.A.. Violation of 2 or more
                                                       validity (SV) model suggests that deliberately poor performance in              Further analyses were performed on available portions of the Leark et             T.O.V.A. SV rules was seen in 95% (18 of 19) of the protocols in the
!   Reaction time for Commission Errors (CERT)         adults can yield: 1) Extreme error scores [Omission and/or Commission
                                                       Error Standard Scores  45]; 2) Extreme RT Variability [! 180 ms]; 3)
                                                       Commission Error RT ! Correct RT; 4) Post-commission Error RT 
                                                                                                                                       al. and Henry data sets to investigate the use of reaction time
                                                                                                                                       differences as an adjunct to extreme errors scores in the formulation of
                                                                                                                                       a strong T.O.V.A. SV model that might prove resistant to coaching.
                                                                                                                                                                                                                         Leark et al. study’s “fake bad” condition, while none of the “good effort”
                                                                                                                                                                                                                         protocols showed violation of more than one SV rule. Available data
                                                                                                                                                                                                                         allowed one RT-based SV rule to be tested in the Henry data set, which
                                                       correct RT. T.O.V.A. SV scores did not correlate with performance on                                                                                              showed promise in the use of RT-based SV rules in discriminating
                                                       other Symptom Validity Tests (SVTs) in a sample of children and                                              CURRENT ANALYSIS                                     between NM and PM personal injury litigants.
                                                       adolescents, suggesting that these rules may not be appropriate for
                                                       use with children and adolescents. Because these RT differences                 The T.O.V.A. is unique among commercially available CPTs in that it                Comparisons of T.O.V.A. fake bad scores with performance on SVTs in
!   Reaction time for Correct Responses (CRRT)         reflect different levels of processing in genuine and deliberately poor
                                                       performance, this method of assessing SV may prove highly resistant
                                                       to deliberate manipulation.
                                                                                                                                        records subjects Response Times (RTs) with ± 1 millisecond accuracy.
                                                                                                                                        This level of precision allows reliable comparison of subtle reaction time
                                                                                                                                        differences that is not possible with less accurate measures. The
                                                                                                                                                                                                                         a group of children and adolescents did not show a clear relationship,
                                                                                                                                                                                                                         suggesting that without motivation for systematic response bias,
                                                                                                                                                                                                                         younger individuals may demonstrate varying levels of effort across
                                                                                                                                        current analysis examined within-subject differences across                      tasks. The T.O.V.A. SV rules may help clinicians identify T.O.V.A.
                                                                                   BACKGROUND                                           Commission Error RT (CERT; reflecting impulsive, incorrect                       protocols that are invalid due to factors such as affective instability,
                                                                                                                                        responding), Correct Responses RT (CRRT; reflecting observation,                 confusion, or poor motivation in this group.
                                                       The T.O.V.A.TM is a computerized CPT that provides information about             evaluation, and correct responding to the target stimulus), and Post
!   Reaction time for correct responses made after a   vigilance, response inhibition, consistency of performance over time,
                                                       and adaptation to to changing task demands. It is widely used to
                                                       assess attention and inhibition and to monitor response to treatment of
                                                                                                                                       -commission-Error Correct RT (PCERT; reflecting post-error RT slowing;
                                                                                                                                        see Li, Huang, Yan, Paliwal, Constable,  Sinha, 2008) in available
                                                                                                                                        portions of the above data sets.
                                                                                                                                                                                                                         SV rules based on intra-subject CERT, CRRT, and PCERT differences
                                                                                                                                                                                                                         show strong potential, as these reaction times are associated with
                                                                                                                                                                                                                         differential levels of cognitive processing. It may be difficult or


    commission error (PCRT)
                                                       attention problems.                                                                                                                                               impossible for those seeking to feign impairment to produce a valid
                                                                                                                                       In addition to non-extreme error scores and non-extreme RT Variability            T.O.V.A. RT profile, and these RT-based SV rules may prove to be quite
                                                       Because CPTs have strong face validity as tests of attention, they are           scores, it was predicted that valid T.O.V.A. protocols would show intra          resistant to coaching.
                                                       likely targets for “faking bad” by persons desiring to simulate poor            -subject Response Time differences consisting of CERT  CRRT, and
                                                       attention. Previous research investigating “fake bad” patterns in college        PCERT  than CRRT. Thus, the reaction time profile for a valid T.O.V.A.          Future work will further test this T.O.V.A. SV model in a simulation study
                                                       students and persons involved in personal injury litigation emphasized           protocol should resemble:                                                        and in populations in which individuals may be motivated to simulate
                                                       extreme error scores as one method for detecting fake bad                                                                                                         attention impairment.


    Valid: CERT  CRRT  PCERT
                                                       performance on the T.O.V.A.                                                                                 CERT  CRRT  PCERT
!
                                                       Leark, et al., (2002) administered the T.O.V.A. to 36 college students          Invalid T.O.V.A. protocols were expected to show violation of one or                                                          Good Effort!        Fake Bad!
                                                       (age = 22.4 ± 2.3) in counterbalanced “fake bad” and “normal” effort             more of these RT relationships, in addition to extreme error scores or                                                         (n=19)             (n=19)
                                                       conditions. In the fake bad condition, extreme scores were noted for             RT variability.                                                                      Showed Full Valid RT Profile            7 (37%)             4 (9%)
                                                       Omission Errors (raw score = 25 ± 27), Commission Errors (raw score
                                                       = 14 ± 17), and Response Time Variability (raw score = 227 ± 118 ms).           College student sample. Raw data files for 19 of Leark et al.’s original              Violated CERT ! CRRT Rule                  0 (0%)           11 (58%)
                                                       Standard scores were not calculable for such extreme values, and are            36 cases were available for additional RT analyses. Comparison of RT                  Violated CRRT ! PCERT Rule                8 (42%)            8 (42%)
                                                       reported as “ 40” in the T.O.V.A. report.                                      profiles and T.O.V.A. SV rules by condition are shown in Table 1.                     Violated Extreme Errors Rule               1 (5%)           14 (74%)
                                                                                                                                                                                                                             Violated Variability ( 180 ms) Rule       0 (0%)           14 (74%)
                                                       Henry (2005) examined the T.O.V.A. performances of 26 personal injury           Personal injury litigants. In available data from the Henry (2005) data
                                                       litigants (age = 37.8 ± 10.9) identified as “Probably Malingering” (PM)         set, 92% of the NM cases passed the CRRT  PCERT rule (23 of 25                       Violated 1 rule                           4 (21%)             1 (5%)
                                                       by their performance on established symptom validity tests (SVTs).              cases), while only 43% of the PM cases passed this rule (9 of 15                      Violated 2 rules                              0              6 (31%)
                                                       Similar to the findings of Leark et al., PM cases demonstrated extreme          cases). Additional RT SV rules could not be calculated from the data                  Violated 3 rules                              0             10 (53%)
                                                       error scores across all T.O.V.A. scores with particularly high rates of         available.                                                                            Violated 4 rules                              0              2 (10%)
                                                       Omission Errors (raw score = 54 ± 72), Commission Errors (raw score                                                                                                      Table1. Intra-subject RT and error rules for Good Effort and Fake Bad
                                                       = 21 ± 40), and high Response Time Variability (raw score = 230 ± 94            Children and Adolescents. The four T.O.V.A. SV rules were tested in a                     conditions in the Leark et al. college student sample.
                                                       ms). Standard scores were not calculable for such extreme values and            sample of 26 children and adolescents (11 female, 15 male; age = 3.3 ±
                                                       are reported as “ 40” in the T.O.V.A. report. Further analysis found that      3.0) who received a neuropsychological evaluation including a series of
SVI Interpretation
!   0-1: No evidence of symptom exaggeration.
!   2: Some evidence of possible symptom exaggeration.
!   3: Strong evidence of possible symptom exaggeration.
!   4: Very strong evidence of symptom exaggeration.
The Future
!   Validate SEI in multiple patient groups
    Try to differentiate “subtle” and “obvious” methods of
                                                             CONCLUSIONS
!

    faking bad
!   Produce final post-test probability estimation based on
    chained likelihood ratios (e.g., Larrabee, 2007)
Conclusions                                                      Conclusions
!   ADHD assessment is “easy” to diagnose but requires          !   Underreporting may also be a concern with some adults.
    consideration of comorbidities and rule outs. This cannot   !   Self-report is easily and credibly faked to suggest the
    all be done with simple diagnostic checklists.
                                                                    presence of ADHD
!   DSM-IV-TR criteria were developed for use with children     !   Use of a good objective measure with integrated “fake
    and must be adapted for use with adolescents and adults.
                                                                    bad” detection based on obligatory psychophysiologic
!   Conceptualization of ADHD as an impairment of executive         signs can be useful in clinical decision making
    functions is guiding the development of ADHD in DSM-V.      !   The T.O.V.A. and T.O.V.A. SEI can plan an important role
    Adult criteria will likely be different for DSM-V.
                                                                    in general and forensic neuropsychological assessment.
!   Malingering is a genuine, very serious concern in work
    with adolescents and adults.




                      Thank you!
           sjh@umn.edu
     www.GoodAtDoingThings.com
            651-895-4802

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Adult Adhdv Criteria Comorbidities Considerations

  • 1. ADHD in Adults: Conflict of interest disclosure: Criteria, Comorbidities, I will be discussing some research that I completed while working as the Director of Education and Research for The TOV A and Caveats Company, publisher of the Test of Variables of Attention™ (T.O.V.A.), which I will be talking about later in this presentation. Steve Hughes, PhD, LP, ABPdN While I view my comments and opinions as expressed to be Assistant Professor of Pediatrics and Neurology accurate, you should judge the facts and materials for yourself and Division of Pediatric Clinical Neurosciences make an independent decision regarding your choice of diagnostic University of Minnesota Medical School and related techniques. Today’s Presentation ! Suitability of DSM-IV-TR criteria for Attention-Deficit/ Hyperactivity Disorder in adults CRITERIA ! Proposed new DSM-V criteria for ADHD in adults ! Adults ADHD and Comorbidities ! Important considerations in diagnosing ADHD in adults
  • 2. ADHD in DSM-IV-TR ! Predominantly Inattentive Type (314.00) ! Predominantly Hyperactive-Impulsive Type (314.01) ! Combined Type (314.01) ! ADHD Not Otherwise Specified (314.9) A. Inattentive Symptoms A. Inattentive Symptoms ! Often does not give close attention to details or makes ! Often avoids, dislikes, or doesn't want to do things that careless mistakes in schoolwork, work, or other activities. take a lot of mental effort for a long period of time (such ! Often has trouble keeping attention on tasks or play as schoolwork or homework). activities. ! Often loses things needed for tasks and activities (e.g. ! Often does not seem to listen when spoken to directly. toys, school assignments, pencils, books, or tools). ! Often does not follow instructions and fails to finish ! Is often easily distracted. schoolwork, chores, or duties in the workplace (not due to ! Is often forgetful in daily activities. oppositional behavior or failure to understand instructions). ! Often has trouble organizing activities.
  • 3. B. Hyperactive/Impulsive B. Hyperactive/Impulsive Symptoms Symptoms ! Often fidgets with hands or feet or squirms in seat. ! Often blurts out answers before questions have been finished. ! Often gets up from seat when inappropriate. ! Often has trouble waiting one’s turn. ! Often runs about or climbs excessively (adolescents or adults, may be limited to feelings of restlessness). ! Often interrupts or intrudes on others (butts into conversations or games). ! Often has difficulty playing quietly. ! Is often “on the go” or acts as if “driven by a motor”. ! Often talks excessively. Additional Criteria Rates of ADHD ! Six or more of A and/or B. ! One of the most common psychiatric disorders in children and adolescents ! Some symptoms that cause impairment were present before age 7 years. ! Worldwide prevalence about 5.3 percent ! Some impairment from the symptoms is present in two or ! In US, 7.8 percent of all school-aged children (about 4.4 more settings (e.g. at school/work and at home). million) aged 4 to 17 years diagnosed with ADHD at some point in their lives (CDC) ! There must be clear evidence of significant impairment in social, school, or work functioning. ! The disorder affects 4.4 to 5 percent of US adults aged 18 to 44 ! The symptoms are not better accounted for by another ! Approximately 9.8 million adults believed to have ADHD mental disorder (e.g. Mood Disorder, Anxiety Disorder, ! (National Comorbidity Survey Replication; Barkley, Murphy, Dissociative Disorder, or a Personality Disorder). & Fischer, 2008)
  • 4. Diagnosis can be relatively straightforward…. Q: What do these all have in common? • Depression • Language disorder ! Interview • Oppositional Defiant Disorder • Physical or sexual abuse ! Patient observation • Anxiety disorder • Post-Traumatic Stress Disorder ! Child Behavior Checklist (parent and teacher) • Learning disability • Head injury • Tourette disorder • Neurological disorder ! Conners Parent and Teacher Rating Scales • Poor social history • Intellectual precocity/ ! ADD-H: Comprehensive Teacher Rating Scale (ACTeRS) • Lead poisoning impairment • Hearing impairment • Dementia ! Vanderbilt Assessment Scales • Family style • Auditory processing problems but... American Academy of Child and Adolescent Psychiatry • Sleep problems • Poor school/job “fit” A: They are all mistaken for ADHD. ADHD in Adults? DSM-IV-TR ADHD was built for Without careful, comprehensive enough use with children evaluation, almost anything that sends a person off the rails can look like “ADHD.”
  • 5. DSM-IV-TR ADHD was built for use with children ! Rate of ADHD does decline with age ! Decline is evident if using threshold cut-scores from questionnaires (e.g., 93rd or 98th percentile) ! Evidence suggests normalization in around 50% of patients followed longitudinally ! Full recovery seen in about 35% ! However, strict application of DSM-IV-TR criteria at transition to adulthood causes dramatic drop in diagnosis (up to 74%) DSM-IV-TR ADHD was built for DSM-IV-TR ADHD was built for use with children use with children ! DSM-IV-TR criteria were never validated in older ! DSM-IV-TR subtypes have no apparent merit for use in adolescents and adults adults ! Symptom threshold / wording / conceptualization all ! “Impairment” is often subjective developed for children ! “Impairment” should not be relative to a high-functioning ! Stipulation of areas of impairment not broad enough for specialized peer group or to IQ older adolescents and adults ! “Style” ≠ “Impairment” ! No real guidelines for determining “impairment” ! For a variety of reasons, self-report is an unreliable ! Age 7 criterion was wholly unempirical in origin and method to ascertain the presence of symptoms severely limits use in adolescents adults
  • 6. Additional considerations Additional considerations ! ADHD is a symptom-complex not a disorder ! ADHD is confusing ! Multiple etiologies, treatments and prognoses ! Ability to “hyper focus” is not addressed ! Diagnostic criteria are behavioral and subjective ! “Executive functions” not in description, yet commonly affected ! “Impairment” is subjectively determined ! Symptoms are situation specific, age-linked, and culture bound ! Symptoms often become manifested after age 7 ! Symptoms are clearly age linked Rethinking ADHD…. Adjusting DSM-IV-TR ! Diagnostic threshold must be adjusted for age ! Current report of 4 or more symptoms from either list, or a total of 7 symptoms from the 18 DSM-IV-TR symptoms: ! Rules out 100% of community control group ! Rules in 87% of ADHD group ! But also rules in 70% of clinical control group! Barkley (2006)
  • 7. “CPTsville” Proposed DSM-V Adult ADHD symptoms ! Often easily distracted by extraneous stimuli or irrelevant thoughts ! Often makes decisions impulsively ! Often has difficulty stopping activities or behavior when should do so ! Often starts projects or tasks without reading or listening to directions carefully ! Often has poor followthrough on promises or commitments he (Also here) or she may make to others After Barkley (2006) ! Often has trouble doing things in proper sequence Proposed DSM-V Adult ADHD Possible DSM-V Adult ADHD symptoms symptoms ! Often drives with excessive speed ! Some impairment present in childhood or adolescence (before age 16) ! Often has difficulty sustaining attention in tasks or leisure time activities ! Some impairment present in two or more settings (work, educational activities, home life, community functioning, social ! Often has trouble organizing tasks and activities relationships) Barkley, Murphy & Fischer (2008) ! Clear evidence of clinically significant impairment in multiple areas of functioning Barkley, Murphy & Fischer (2008)
  • 8. COMORBIDITIES Comorbidity in children 1216 BIOL PSYCHIATRY 2005;57:1215–1220 Comorbidity in children J. Biederman ! Almost one-third of children with ADHD have more than one comorbid condition. DOHHS, Agency for Healthcare Research and Quality Figure 2. Approximate prevalence of comorbid diagnoses in adults with attention-deficit/hyperactivity disorder. Figure 1. Approximate prevalence of comorbid diagnoses in children with attention-deficit/hyperactivity disorder. 2004). Lifetime prevalence rates of comorbid anxiety disorders in adults with ADHD approach 50%, whereas mood disorders, Biederman J. (2005). Attention-Deficit/hyperactivity disorder: A selective overview. Biolantisocial disorders, and alcohol/drug dependency also show three domains; 20% did well in all three domains; and 60% had Psychiatry 57, 1215-1220. intermediate outcomes. These findings suggest that the syn- substantial prevalence rates (Figure 2) (Biederman et al 1993, dromic persistence of ADHD is not associated with a uniform 1994; Shekim et al 1990). Findings from a new, large sample of functional outcome; rather, it leads to a wide range of emotional, male and female adults with and without ADHD provide com- educational, and social adjustment outcomes that can be partially pelling evidence for the validity of adult ADHD and document predicted. More work is needed, however, to disentangle the strikingly similar phenotypic features of the disorder in both role of treatment on outcome. genders (Biederman et al 2004). Consistent with previous find- ings, this study documented high rates of mood and anxiety
  • 9. 215–1220 Comorbidity in Adults J. Biederman Q: What do these all have in common? • Depression • Language disorder • Oppositional Defiant Disorder • Physical or sexual abuse • Anxiety disorder • Post-Traumatic Stress Disorder • Learning disability • Head injury • Tourette disorder • Neurological disorder • Poor social history • Intellectual precocity/ • Lead poisoning impairment • Hearing impairment • Dementia Figure 2. Approximate prevalence of comorbid diagnoses in adults with attention-deficit/hyperactivity disorder. • Auditory processing problems • Family style d diagnoses in children with • Poor school/job “fit” 2004). Lifetime prevalence rates of comorbid anxiety disorders in • Sleep problems adults with ADHD approach 50%, whereas mood disorders, Biederman J. (2005). Attention-Deficit/hyperactivity disorder: A selective overview. Biol Psychiatry domains; and57, 1215-1220. antisocial disorders, and alcohol/drug dependency also show 60% had suggest that the syn- substantial prevalence rates (Figure 2) (Biederman et al 1993, A: They are all mistaken for ADHD. ociated with a uniform 1994; Shekim et al 1990). Findings from a new, large sample of wide range of emotional, male and female adults with and without ADHD provide com- mes that can be partially pelling evidence for the validity of adult ADHD and document ver, to disentangle the strikingly similar phenotypic features of the disorder in both genders (Biederman et al 2004). Consistent with previous find- Best practice: Multi-method ings, this study documented high rates of mood and anxiety disorders in adults with ADHD, with a female predominance. cal feature observed in n children, psychiatric Genetics and ADHD Familial Influence assessment approach de oppositional defiant Family studies of ADHD have consistently supported its ders (both unipolar and strong familial nature (Faraone and Doyle 2001; Faraone and ! Must consider rule-outs and comorbidities disorders (Kessler 2004; “The goal1995). Despite nosologic changes, thereis to provide a Tsuang of a comprehensive evaluation is remarkable bidity can occur due to nd Rutter 1991), recent model oras between early(Cantwell 1972; Morrison and Stewart agreement defined studies of children whose illness was diagnosis that: (a) accurately characterizes an hyperactivity ! Must ascertain DSM-IV-TR symptoms of ADHD artifacts cannot explain individual’s functioning; (b) facilitates thinkingDSM-III-R 1971) and subsequent studies using DSM-III and about the ty observed for ADHD individual; (c) explains his or (Biederman et al 1990; Faraone definitions of ADHD (Figure 3) her current difficulties; and ! Should establish a baseline for treatment monitoring the prevalence rates of et al 1992; Frick et al 1991; Schachar and Wachsmuth 1990). Most (d) guides effective intervention” (Hughes, 2008). hood ADHD and how family studies have identified a two- to eightfold increase in the ! Should address ongoing need for treatment t to gender (Biederman risk for ADHD in parents and siblings of children with ADHD t al 1999). (Biederman et al 1990; Cantwell 1972; Faraone et al 1992; Frick ! Should include multimodal treatment strategy pact of gender on the et al 1991; Manshadi et al 1983; Morrison and Stewart 1971; Pauls al (2002) reported that et al 1983; Schachar and Wachsmuth 1990; Welner et al 1977). A or comorbid disruptive study of siblings of adults with ADHD (Manshadi et al 1983) and ! May require case coordination HD. Because disruptive nding might explain the ! May require reformulation if “model” does not provide ale ratio between clinic- mples of children with predicted outcomes ore, this gender discrep- ght be under-identified
  • 10. “Clinicians should consider utilizing several methods of establishing impairment, such as a combination of patient-reported history, corroboration through others who know the patient well, CAVEATS and archival records that may reflect such impairment, as in school, medical, mental health, employment, criminal and driving records” (p. 39-40, Barkley, Murphy & Fischer, 2008). Under-reporting of symptoms Malingering
  • 11. ADHD and under-reporting ADHD and under-reporting ! ADHD symptoms may be overlooked in persons being “Patients may also lack insight into their problems and treated for other psychiatric illness assume that their ADHD symptoms are personality or ! Some patients are hesitant to admit to “poor character” character traits. They may not understand the manner in which ADHD symptoms appear in an adult. For these and other reasons, patients may fail to mention ADHD symptoms to their healthcare provider unless they are specifically asked” (p. 978, Barkley & Brown, 2008). A young man I’ll call Alex recently graduated from Harvard. As a history major, Alex wrote about a dozen papers a semester. He also ran a student organization, for which he often worked more than forty hours a week; when he wasn’t on the job, he had classes. Weeknights were devoted to all the schoolwork that he couldn’t finish during the day, and weekend nights were spent drinking with friends and going to dance parties. “Trite as it sounds,” he told me, it seemed important to “maybe appreciate my own youth.” Since, in essence, this life was impossible, Alex began taking Adderall to make it possible. From“Brain Gain: The underground world of neuroenhancing drugs.” The New Yorker, April 27, 2009.
  • 12. Malingering is a big problem in Malingering is a big problem in adult ADHD work adult ADHD work ! Adults malinger to obtain: ! Special dispensations ! Medication to sell or trade ! Extended time on exams ! Medication to abuse ! Reduced work load ! Medication for “neuroenhancement” Malingering is a big problem in ADHD and Malingering adult ADHD work ! To win lawsuits ! Rates of symptom exaggeration / malingering may approach 50% among treatment seeking college students ! “...clinicians who rely upon self-report measures in the absence of performance-based symptom validity measures in ADHD assessment are probably risking far more false-positives than they suspect” (Sullivan, May, & Galbally, 2007)
  • 13. Self-report is easily faked “In analyzing the performance of students simulating ADHD, and comparing it to performance of both non- Heilbronner, R.L., Sweet, J.J., Morgan, J.E., Larrabee, G.J., Millis, S.R. ADHD and genuine ADHD students, this study clearly (2009). American academy of clinical neuropsychology consensus demonstrated that the symptoms of ADHD are easily conference statement on the neuropsychological assessment of effort, response bias, and malingering. The Clinical Neuropsychologist, 23, fabricated, and that simulators would be 1093-1129. indistinguishable from those with true ADHD” (p. 577, Harrison, Edwards & Parker, 2007). Some of the recommendations The evaluation of self-reported symptoms is best accomplished using Development of the T.O.V.A. ! psychometric instruments containing proven validity measures. ! If possible clinicians should use multiple validity measures covering multiple domains distributed throughout the testing. Symptom Exaggeration Index ! If testing must be brief (e.g., Social Security disability evaluations), minimally, embedded effort indicators should be examined. ! Stand-alone effort measures and embedded validity indicators should both be employed. Heilbronner, R.L., Sweet, J.J., Morgan, J.E., Larrabee, G.J., Millis, S.R. (2009). American academy of clinical neuropsychology consensus conference statement on the neuropsychological assessment of effort, response bias, and malingering. The Clinical Neuropsychologist, 23, 1093-1129.
  • 14. The Clinical Neuropsychologist, 19: 121–129, 2005 Copyright # Taylor and Francis Ltd. ISSN: 1385-4046 DOI: 10.1080=13854040490516604 Downloaded By: [University of Minnesota] At: 04:18 3 June 2007 Archives of Clinical Neuropsychology 17 (2002) 335 – 342 PROBABLE MALINGERING AND PERFORMANCE ON THE TEST OF VARIABLES OF ATTENTION George K. Henry Fake bad test response bias effects on the Los Angeles Neuropsychology Group, Los Angeles, CA, USA test of variables of attention$ Fifty subjects with mild head injury involved in personal injury litigation and 2 subjects referred for evaluation of their disability status underwent comprehensive neuropsycholo- Robert A. Leark*, Dennis Dixon, Tiffany Hoffman, Donna Huynh gical examination including the Test of Variables of Attention (TOVA). Group status was determined by performance on symptom validity testing. Twenty-six subjects who Psychology Department, Pacific Christian College, 2500 East Nutwood Avenue, failed symptom validity testing formed the probable malingering (PM) group, while 26 Fullerton, CA 92831, USA subjects who passed symptom validity testing comprised the not malingering (NM) group. Subjects in the PM group performed significantly worse on all TOVA variables Accepted 5 February 2001 relative to subjects in the NM group. Discriminant function analyses revealed that TOVA omission errors 3 errors was the best predictor of group status. Malingering research employing a group of probable clinical malingerers has direct generalizability to real- world settings. Abstract This study investigated the effects of faking bad (FB) on the Test Of Variables of Attention (TOVA) using subjects randomly placed into two groups. Subjects in Group 1 took the TOVA under INTRODUCTION normal conditions (NC) first; they were then requested to subtly fake bad. Group 2 subjects took the Neuropsychologists are increasingly being called upon to render expert opi- TOVA under the same fake bad instructions first, then took the test under normal conditions the nions in the forensic area. The science upon which these opinions are based must second time. An analysis of the effects of test order yielded non-significant differences for basic meet acceptable standards of reliability and validity. Confidence in the reliability TOVA variables across all four quarters, both halves and the total score. An analysis for group mean and validity of the test data generated during the neuropsychological evaluation is differences between the NC and the FB instructions yielded significant differences across the basic directly related to the examinee’s effort. In recent years the development of symp- TOVA variables across the four quarters, two halves and total score. The FB group had excessive tom validity tests (SVTs) such as the Test of Memory Malingering (TOMM; amounts of omission and commission errors, a greater response time mean (i.e., slower to respond) Tombaugh, 1996), Word Memory Test (WMT; Green, Allen, Astner, 1996), and had greater variance around their mean response time. The study affirms that the professional and Computerized Assessment of Response Bias (CARB; Condor, Allen, using the TOVA needs to carefully eliminate a fake bad test-taking bias when subjects produce Cox, 1992) have emerged on the scene to assist clinicians in objectively measuring excessive test results. D 2002 National Academy of Neuropsychology. Published by Elsevier one’s effort. There has also been a growing interest in developing effort indices on Science Ltd. standardized neuropsychological tests in order to provide additional data on which to base effort opinions (Suhr Boyer, 1999; Mittenberg, Rotholic, Russell, Keywords: TOVA; Continuous performance test; CPT; Fake bad Heilbronner, 1996; Greiffenstein, Baker, Gola, 1996; Millis, Putnam, Adams, Ricker, 1995; Mittenberg et al., 2001), but also to control for attorney coaching. One survey of 70 attorneys (Wetter Corrigan, 1995) found that 79% believed that a discussion with the client about what psychological testing involves should take place prior to evaluation, while 47% reported that the attorney should $ Address correspondence to: George K. Henry, Ph.D.=ABPP-CN, Los Angeles Neuropsychology Portions of this paper were presented as a poster paper at the 19th Annual Meeting of the National Academy Group, 1950 Sawtelle Blvd., Suite 342, Los Angeles, CA 90025, USA. Tel.: 310 457 0777. Fax: 310 457 of Neuropsychology, San Antonio, TX, November 1999. The TOVA Research Foundation supplied use of the test 0777. E-mail: GHenry0249@aol.com for this research project. Accepted for publication: April 15, 2004. * Corresponding author. Tel.: +1-714-879-3901; fax: +1-714-879-1041. E-mail address: bleark@hiu.edu (R.A. Leark). 121 0887-6177/02/$ – see front matter D 2002 National Academy of Neuropsychology. PII: S 0 8 8 7 - 6 1 7 7 ( 0 1 ) 0 0 11 8 - 4 Leark et al. (2002) Henry (2005) ! 36 college students counterbalanced “good effort” and ! 52 personal injury litigants “fake bad” conditions ! 26 Classified as “Probably Malingering” ! Excessive: ! 26 classified“Not Malingering” based on established SVTs ! Commission Errors (raw score = 14 +/- 17) ! PM showed Excessive: ! Omission Errors (raw score = 25 +/- 27) ! Commission Errors (Raw score = 21 +/- 39) ! RT Variability (227 +/- 118 ms) ! Omission Errors (raw score = 54 +/- 72) ! RT Variability (230 +/- 94 ms)
  • 15. Goals for TOVA SEI ! Extend current research ! Leverage accurate RT measurement ! Seek obligatory differences between good effort and “fake bad” ! Identify subtle vs. obvious “tells” ! Yield probabilistic interpretation based on sum of multiple indicators From Henry (2005) ! Differentiate “exaggeration” from frank malingering Valid TOVA Pattern Acceptable RT Variability Evidence of Post-error Slowing Non-excessive Errors (raw score)
  • 16. Edith Kaplan, PhD (February 16, 1924 - September 3, 2009) “Edithʼs Rule” Commission Error RT should be Correct Response RT Using the Test of Variables of Attention (T.O.V.A.TM) to Detect Deliberate Poor Performance During Assessment of Attention Steven J. Hughes1, Robert A. Leark2, George K. Henry3, Ellen L. Robertson4, Lawrence M. Greenberg1 1The TOVA Company, Los Alamitos, CA; 2Pacific Christian College, Fullerton, CA; 3Los Angeles Neuropsychology Group, Los Angeles, CA; 4Flaro and Associates, Edmonton, Alberta Within subject RT profile ABSTRACT a cut score of 3 Omission Errors yielded a sensitivity of 88.5% and a established SVTs (WMT MSVT; Green 2003, 2008). Valid RT profiles specificity of 80.8% in predicting PM versus probably Not Malingering were seen in 11 cases (31%). There was no discernable pattern of SVT Efforts to exaggerate impairment through intentionally poor (NM; a matched group of individuals who passed symptom validity performance observed between specific T.O.V.A. SV rules and the performance can adversely affect the results of Continuous tests). results of the SVTs. Performance Tests (CPTs). Previous research with the T.O.V.A.TM has identified extreme error scores and high reaction time variability as These studies showed that extreme error rates are useful in identifying DISCUSSION characteristics of deliberate poor performance (Leark, Dixon, Hoffman persons attempting to exaggerate impairment on the T.O.V.A. However, Huynh, 2001; Henry, 2005). Further analysis of these data sets with simple coaching, motivated malingerers could easily reduce error Combination of “overt” signs of symptom exaggeration based on shows that differences in error and post-error reaction times (RTs) can rates to a more “typically impaired” level, thereby reducing their extreme error scores and “subtle” signs based on intra-subject reaction also distinguish valid T.O.V.A. protocols from those obtained under likelihood of being identified. time differences shows promise as a method to improve detection of conditions of symptom exaggeration. A preliminary T.O.V.A. symptom deliberate fake bad responding on the T.O.V.A.. Violation of 2 or more validity (SV) model suggests that deliberately poor performance in Further analyses were performed on available portions of the Leark et T.O.V.A. SV rules was seen in 95% (18 of 19) of the protocols in the ! Reaction time for Commission Errors (CERT) adults can yield: 1) Extreme error scores [Omission and/or Commission Error Standard Scores 45]; 2) Extreme RT Variability [! 180 ms]; 3) Commission Error RT ! Correct RT; 4) Post-commission Error RT al. and Henry data sets to investigate the use of reaction time differences as an adjunct to extreme errors scores in the formulation of a strong T.O.V.A. SV model that might prove resistant to coaching. Leark et al. study’s “fake bad” condition, while none of the “good effort” protocols showed violation of more than one SV rule. Available data allowed one RT-based SV rule to be tested in the Henry data set, which correct RT. T.O.V.A. SV scores did not correlate with performance on showed promise in the use of RT-based SV rules in discriminating other Symptom Validity Tests (SVTs) in a sample of children and CURRENT ANALYSIS between NM and PM personal injury litigants. adolescents, suggesting that these rules may not be appropriate for use with children and adolescents. Because these RT differences The T.O.V.A. is unique among commercially available CPTs in that it Comparisons of T.O.V.A. fake bad scores with performance on SVTs in ! Reaction time for Correct Responses (CRRT) reflect different levels of processing in genuine and deliberately poor performance, this method of assessing SV may prove highly resistant to deliberate manipulation. records subjects Response Times (RTs) with ± 1 millisecond accuracy. This level of precision allows reliable comparison of subtle reaction time differences that is not possible with less accurate measures. The a group of children and adolescents did not show a clear relationship, suggesting that without motivation for systematic response bias, younger individuals may demonstrate varying levels of effort across current analysis examined within-subject differences across tasks. The T.O.V.A. SV rules may help clinicians identify T.O.V.A. BACKGROUND Commission Error RT (CERT; reflecting impulsive, incorrect protocols that are invalid due to factors such as affective instability, responding), Correct Responses RT (CRRT; reflecting observation, confusion, or poor motivation in this group. The T.O.V.A.TM is a computerized CPT that provides information about evaluation, and correct responding to the target stimulus), and Post ! Reaction time for correct responses made after a vigilance, response inhibition, consistency of performance over time, and adaptation to to changing task demands. It is widely used to assess attention and inhibition and to monitor response to treatment of -commission-Error Correct RT (PCERT; reflecting post-error RT slowing; see Li, Huang, Yan, Paliwal, Constable, Sinha, 2008) in available portions of the above data sets. SV rules based on intra-subject CERT, CRRT, and PCERT differences show strong potential, as these reaction times are associated with differential levels of cognitive processing. It may be difficult or commission error (PCRT) attention problems. impossible for those seeking to feign impairment to produce a valid In addition to non-extreme error scores and non-extreme RT Variability T.O.V.A. RT profile, and these RT-based SV rules may prove to be quite Because CPTs have strong face validity as tests of attention, they are scores, it was predicted that valid T.O.V.A. protocols would show intra resistant to coaching. likely targets for “faking bad” by persons desiring to simulate poor -subject Response Time differences consisting of CERT CRRT, and attention. Previous research investigating “fake bad” patterns in college PCERT than CRRT. Thus, the reaction time profile for a valid T.O.V.A. Future work will further test this T.O.V.A. SV model in a simulation study students and persons involved in personal injury litigation emphasized protocol should resemble: and in populations in which individuals may be motivated to simulate extreme error scores as one method for detecting fake bad attention impairment. Valid: CERT CRRT PCERT performance on the T.O.V.A. CERT CRRT PCERT ! Leark, et al., (2002) administered the T.O.V.A. to 36 college students Invalid T.O.V.A. protocols were expected to show violation of one or Good Effort! Fake Bad! (age = 22.4 ± 2.3) in counterbalanced “fake bad” and “normal” effort more of these RT relationships, in addition to extreme error scores or (n=19) (n=19) conditions. In the fake bad condition, extreme scores were noted for RT variability. Showed Full Valid RT Profile 7 (37%) 4 (9%) Omission Errors (raw score = 25 ± 27), Commission Errors (raw score = 14 ± 17), and Response Time Variability (raw score = 227 ± 118 ms). College student sample. Raw data files for 19 of Leark et al.’s original Violated CERT ! CRRT Rule 0 (0%) 11 (58%) Standard scores were not calculable for such extreme values, and are 36 cases were available for additional RT analyses. Comparison of RT Violated CRRT ! PCERT Rule 8 (42%) 8 (42%) reported as “ 40” in the T.O.V.A. report. profiles and T.O.V.A. SV rules by condition are shown in Table 1. Violated Extreme Errors Rule 1 (5%) 14 (74%) Violated Variability ( 180 ms) Rule 0 (0%) 14 (74%) Henry (2005) examined the T.O.V.A. performances of 26 personal injury Personal injury litigants. In available data from the Henry (2005) data litigants (age = 37.8 ± 10.9) identified as “Probably Malingering” (PM) set, 92% of the NM cases passed the CRRT PCERT rule (23 of 25 Violated 1 rule 4 (21%) 1 (5%) by their performance on established symptom validity tests (SVTs). cases), while only 43% of the PM cases passed this rule (9 of 15 Violated 2 rules 0 6 (31%) Similar to the findings of Leark et al., PM cases demonstrated extreme cases). Additional RT SV rules could not be calculated from the data Violated 3 rules 0 10 (53%) error scores across all T.O.V.A. scores with particularly high rates of available. Violated 4 rules 0 2 (10%) Omission Errors (raw score = 54 ± 72), Commission Errors (raw score Table1. Intra-subject RT and error rules for Good Effort and Fake Bad = 21 ± 40), and high Response Time Variability (raw score = 230 ± 94 Children and Adolescents. The four T.O.V.A. SV rules were tested in a conditions in the Leark et al. college student sample. ms). Standard scores were not calculable for such extreme values and sample of 26 children and adolescents (11 female, 15 male; age = 3.3 ± are reported as “ 40” in the T.O.V.A. report. Further analysis found that 3.0) who received a neuropsychological evaluation including a series of
  • 17. SVI Interpretation ! 0-1: No evidence of symptom exaggeration. ! 2: Some evidence of possible symptom exaggeration. ! 3: Strong evidence of possible symptom exaggeration. ! 4: Very strong evidence of symptom exaggeration.
  • 18.
  • 19. The Future ! Validate SEI in multiple patient groups Try to differentiate “subtle” and “obvious” methods of CONCLUSIONS ! faking bad ! Produce final post-test probability estimation based on chained likelihood ratios (e.g., Larrabee, 2007)
  • 20. Conclusions Conclusions ! ADHD assessment is “easy” to diagnose but requires ! Underreporting may also be a concern with some adults. consideration of comorbidities and rule outs. This cannot ! Self-report is easily and credibly faked to suggest the all be done with simple diagnostic checklists. presence of ADHD ! DSM-IV-TR criteria were developed for use with children ! Use of a good objective measure with integrated “fake and must be adapted for use with adolescents and adults. bad” detection based on obligatory psychophysiologic ! Conceptualization of ADHD as an impairment of executive signs can be useful in clinical decision making functions is guiding the development of ADHD in DSM-V. ! The T.O.V.A. and T.O.V.A. SEI can plan an important role Adult criteria will likely be different for DSM-V. in general and forensic neuropsychological assessment. ! Malingering is a genuine, very serious concern in work with adolescents and adults. Thank you! sjh@umn.edu www.GoodAtDoingThings.com 651-895-4802