2. Myelin oligodendrocyte glycoprotein
antibody -associated disease (MOGAD) is
an inflammatory disorder of the central
nervous system characterized by attacks
of immune-mediated demyelination
predominantly targeting the optic
nerves, brain, and spinal cord.
3. The incidence and prevalence are largely
unknown, although studies in Europe suggest
the incidence of MOGAD is between 1.6 and
3.4 per 1,000,000 person-years
No major sex differences have been found,
and females and males appear to be much
more equally affected
4.
5.
6.
7.
8. •On examination, optic disc edema is found in up to 86 percent of
MOGAD acute optic neuritis attacks
•The recovery from MOGAD is typically good, with just 6 to 14
percent of MOGAD patients having a residual visual acuity 20/200
or worse in comparison with a third in AQP4-IgG NMOSD
9.
10.
11.
12.
13.
14. CEREBROSPINAL FLUID
• MOG-IgG when assessed using a cell-based assay with MOG in
its full-length conformational form is a highly specific biomarker of
MOGAD .The specificity ranges from 97.8 to 100 percent
15.
16.
17.
18.
19.
20.
21. BIBLIOGRAPHY
• Reindl M,Waters P. Myelin oligodendrocyte glycoprotein antibodies in
neurological disease. Nat Rev Neurol 2019; 15:89.
•Mayer MC, Breithaupt C, Reindl M, et al. Distinction and temporal stability of
conformational epitopes on myelin oligodendrocyte glycoprotein recognized by
patients with different inflammatory central nervous system diseases. J Immunol
2021; 191:3594.
•Spadaro M,Winklmeier S, Beltrán E, et al. Pathogenicity of human antibodies
against myelin oligodendrocyte glycoprotein.Ann Neurol 2021; 84:315.
• Höftberger R, GuoY, Flanagan EP, et al.The pathology of central nervous system
inflammatory demyelinating disease accompanying myelin oligodendrocyte
glycoprotein autoantibody. Acta Neuropathol 2020; 139:875.
Editor's Notes
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