Neuroborreliosis, also known as Lyme disease, is an infectious disease caused by the bacterium Borrelia burgdorferi, which can be transmitted to humans via tick bites. The document discusses the epidemiology, symptoms, complications, diagnosis, and treatment of neuroborreliosis. Symptoms may include flu-like symptoms, rashes, joint pain, and neurological problems. Diagnosis involves testing for antibodies in blood and spinal fluid. Treatment consists of antibiotics like doxycycline or amoxicillin. Prevention involves avoiding tick bites by using repellent and checking for ticks after being outdoors.

1. Neuroborreliosis
Name: Khalid Al-Kuwity
ID:213119354
Tutor: DR. Ansari

2. Objectives
• Neuroborreliosis
• Epidemiology
• Complication
• Multiple Sclerosis
• Neuroborreliosis v.s M.S
• Diagnosis
• Clinical features
• Treatment
• Prevention

3. Neuroborreliosis
Lyme disease
(Neuroborreliosis ) is an
infectious disease caused
by the bacterium Borrelia
burgdorferi .
Lyme disease can be
transmitted to humans by
the bite of an infected tick.

4. What is Borreliosis?
• The genus Borrelia is a
member of the larger
family of spiral-shaped
bacteria called
Spirochaetes and the
bacteria can be termed as
a Borreliosis.

5. Cont…
• There are many species of Borrelia
bacteria worldwide, but not all of them
cause the disease.
• There are only 3 species that known to
cause the disease:
1- Borrelia burgdorferi.
2- Borrelia afzelii.
3- Borrelia garinii.

6. Symptoms
• Flu-like.
• Erythema migrans (EM)
Rash.
• Headache.
• Stiff neck.
• Muscle pain.
• Tender glands
• sensitivity to temperature
,sound and light levels

7. Con…
• Extreme tiredness.
• Muscle weakness.
• Joint pain.
• Upset digestive system.
• Disturbances of the central nervous
system
• Sleep problems.

8. Con…

9. Epidemiology

10. Risk Factors
• Spending time in wooded or grassy
areas.
• Having exposed skin.
• Not removing ticks promptly or
properly.

11. Complications
• Chronic joint inflammation (Lyme
arthritis) commonly in the knee.
• Neurological symptoms, such as facial
palsy and neuropathy.
• Cognitive defects, such as impaired
memory.
• Heart rhythm irregularities

12. Multiple Sclerosis

13. Neuroborreliosis v.s M.S

14. *Golden Key
Mutable SclerosisLyme Disease
Effect only the CNS  UMN
IgG oligoclonal band in the
CSF
Parathesia (transit) not sever
pain and not persist
Effect the CNS,PNS  UMN,
LMN
Present with organism
antibody ( IgM, IgG) in the
CSF
Sever burning pain

15. Diagnosis
• Clinical features.
• IgM antibodies detected in the 1st
month.
• IgG late in the disease.
• Enzyme-linked immunosorbent assay
(ELISA).
• CSF (cerebrospinal fluid).
• Polymerase chain reaction (PCR).

16. Clinical Features
Skin stage :present
with erythmea
migrans. Associate
with fever and
headache
Neurologic
and cardiac
stage
Chronic
Arthritis
stage
Several day
to weeks or
months
If not
treated

18. Treatment
• Antibacterial tablet ( Amoxicillin,
doxycycline)
• Intravenous administration of ceftriaxone,
cefotaxim or benzyl-pienicillin.

19. Prevention
• Wear long pants and long sleeves.
• Use insect repellents.
• Do your best to tick-proof your yard.
• Check yourself, your children and your
pets for ticks.
• Don't assume you're immune.
• Remove a tick as soon as possible.

20. References
• 111-120, 130 1478-1481 352
156-161
• http://www.mayoclinic.org/diseases-
conditions/lyme-disease/basics.
• http://www.lymediseaseaction.org.uk

22. Thank You