Sean Massey discusses home lab basics, including why to build a home lab for training, certification preparation, and testing non-production environments. He provides guidelines for building a home lab such as starting small with a hypervisor like Workstation or Fusion, understanding requirements and constraints like budget and space, investing in SSD storage, and obtaining free or low-cost software and operating systems. Methods for stocking a lab include buying new, used, or building your own systems, and using cloud options for some learning workloads.